{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:35:37Z","timestamp":1789097737636,"version":"build-2803163510"},"reference-count":99,"publisher":"Bioscientifica","issue":"9","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,21]]},"abstract":"<jats:p>Many clinical and experimental studies have implicated the growth hormone (GH)\u2013insulin-like growth factor (IGF-1) axis with the progression of cancer. The epidemiological finding that patients with Laron syndrome (LS), the best-characterized disease under the spectrum of congenital IGF-1 deficiencies, do not develop cancer is of major scientific and translational relevance. The evasion of LS patients from cancer emphasizes the central role of the GH\u2013IGF-1 system in cancer biology. To identify genes that are differentially expressed in LS and that might provide a biological foundation for cancer protection, we have recently conducted genome-wide profiling of LS patients and normal controls. Analyses were performed on immortalized lymphoblastoid cell lines derived from individual patients. Bioinformatic analyses identified a series of genes that are either over- or under-represented in LS. Differential expression was demonstrated in a number of gene families, including cell cycle, metabolic control, cytokine\u2013cytokine receptor interaction, Jak-STAT and PI3K-AKT signaling, etc. Major differences between LS and controls were also noticed in pathways associated with cell cycle distribution, apoptosis, and autophagy. The identification of novel downstream targets of the GH\u2013IGF-1 network highlights the biological complexity of this hormonal system and sheds light on previously unrecognized mechanistic aspects associated with GH\u2013IGF-1 action in the cancer cell.<\/jats:p>","DOI":"10.1530\/erc-22-0394","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T18:32:06Z","timestamp":1687372326000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":16,"title":["Congenital IGF-1 deficiency protects from cancer: lessons from Laron syndrome"],"prefix":"10.1530","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-5758","authenticated-orcid":true,"given":"Zvi","family":"Laron","sequence":"first","affiliation":[{"name":"Endocrinology and Diabetes Research Unit, Schneider Children\u2019s Medical Center, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"New England Journal of Medicine","first-page":"2211","article-title":"IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation","volume":"349","author":"Abuzzahab","year":"2003","unstructured":"Abuzzahab MJSchneider AGoddard AGrigorescu FLautier CKeller EKiess WKlammt JKratzsch JOsgood D, 2003IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. 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