{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:38Z","timestamp":1784557238265,"version":"3.55.0"},"reference-count":37,"publisher":"Bioscientifica","issue":"10","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,8,21]]},"abstract":"<jats:p>\n                    The infiltrating microbiota represents a novel cellular component of the solid tumour microenvironment that can influence tumour progression and response to therapy. Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy for which mitotane (MTT) treatment represents the first-line therapy, though its efficacy is limited to a therapeutic window level (14\u201320 mg\/L). Novel markers able to predict those patients who would benefit from MTT therapy are urgently needed to improve patient\u2019s management. The aim of our study was to evaluate the presence of intratumoural bacterial microbiota DNA in 26 human ACC tissues vs 9 healthy adrenals; moreover, the association between the relative bacterial composition profile, the tumour mass characteristics and MTT ability to reach high circulating levels in the early phase of treatment, were explored. We found the presence of bacterial DNA in all adrenal samples from both tumours and healthy cortex specimens, documenting significant differences in the microbial composition between malignancy and normal adrenals: in detail, the ACC tissues were characterised by a higher abundance of the Proteobacteria phylum (especially the\n                    <jats:italic>Pseudomonas<\/jats:italic>\n                    and\n                    <jats:italic>Serratia<\/jats:italic>\n                    genera). In addition, the Proteobacteria\u2019s low abundance was negatively associated with tumour size, Ki67 and cortisol secretion. MTT levels reached higher levels at 9 months in ACC patients with high abundance of Proteobacteria,\n                    <jats:italic>Pseudomonas<\/jats:italic>\n                    and\n                    <jats:italic>Serratia<\/jats:italic>\n                    and with low abundance of Bacteroidota, Firmicutes and\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    . These findings are the first indication that human ACCs are characterised by infiltrating bacteria and their specific abundance profile seems to influence the increase in circulating MTT levels at 9 months.\n                  <\/jats:p>","DOI":"10.1530\/erc-23-0094","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T17:05:59Z","timestamp":1693328759000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":12,"title":["Intratumour microbiota modulates adrenocortical cancer responsiveness to mitotane"],"prefix":"10.1530","volume":"30","author":[{"given":"Giulia","family":"Cantini","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy"},{"name":"European Network for the Study of Adrenal Tumors (ENS@T) Center of Excellence, Florence, Italy"},{"name":"Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy"},{"name":"Istituto Nazionale Biostrutture e Biosistemi (I.N.B.B.), via delle Medaglie D\u2019Oro, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Niccolai","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Canu","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy"},{"name":"European Network for the Study of Adrenal Tumors (ENS@T) Center of Excellence, Florence, Italy"},{"name":"Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Di Gloria","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, Biochemical Sciences Section, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Baldi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna Pia","family":"Propato","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy"},{"name":"European Network for the Study of Adrenal Tumors (ENS@T) Center of Excellence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy"},{"name":"European Network for the Study of Adrenal Tumors (ENS@T) Center of Excellence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Nannini","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Puglisi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences, Internal Medicine, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Nesi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Pathology Section, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Ramazzotti","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, Biochemical Sciences Section, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6797-9343","authenticated-orcid":true,"given":"Amedeo","family":"Amedei","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5186-064X","authenticated-orcid":true,"given":"Michaela","family":"Luconi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy"},{"name":"European Network for the Study of Adrenal Tumors (ENS@T) 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