{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:20:11Z","timestamp":1783592411449,"version":"3.55.0"},"reference-count":27,"publisher":"Bioscientifica","issue":"5","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The association between acromegaly and cancer had been assessed mainly in population studies with inconsistent results. The objective of this study was to investigate the risk of cancer in a large cohort of patients with acromegaly compared with matched controls. The comprehensive computerized database of the largest healthcare provider organization in Israel was searched for patients diagnosed with acromegaly in 2000\u20132021. All diagnoses were qualitatively validated. Patients were individually matched 1:5 with a control group for age, sex and socioeconomic status. Clinical and outcome data were collected from medical files. The final cohort consisted of 470 patients (54% male) with acromegaly and 2,330 control subjects. The mean age at diagnosis was 53 years, and the mean duration of follow-up after diagnosis was 10.4 years. The prevalence of solid malignancies was 21.3% in the acromegaly group and 14.8% in the control group (OR 1.6, 95% CI 1.2\u20132.0). Patients with acromegaly had a higher rate of thyroid cancer (2.8 vs 0.6%; OR 5.1, CI 2.3\u201311.0) and a tendency for a higher risk of colorectal cancer (3.6 vs 2.8%; OR 1.3, CI 0.7\u20132.2), prostate cancer (2.8 vs 1.7%; OR 1.6, CI 0.8\u20133.1) and renal cancer (1.5 vs 0.8%; OR 1.8, CI 0.8\u20134.4), but not hematological malignancies. They also had a higher mortality rate (21.3 vs 15.7%; OR 1.5, CI 1.1\u20131.9). In conclusion, the higher prevalence of malignant solid tumors in patients with acromegaly compared with control subjects suggests that periodic screening for early detection of solid cancers may be considered in this patient population.<\/jats:p>","DOI":"10.1530\/erc-24-0087","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T09:09:42Z","timestamp":1741597782000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":7,"title":["Increased cancer risk in a cohort of patients with acromegaly in Israel"],"prefix":"10.1530","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1721-1360","authenticated-orcid":true,"given":"Hadar","family":"Duskin-Bitan","sequence":"first","affiliation":[{"name":"Institute of Endocrinology, Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, and School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University 1 , ,","place":["Tel Aviv, Israel"]},{"name":"Clalit Health Services 2 , ,","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Perez","sequence":"additional","affiliation":[{"name":"Clalit Health Services 2 , ,","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Netzer","sequence":"additional","affiliation":[{"name":"Clalit Health Services 2 , ,","place":["Tel Aviv, Israel"]},{"name":"Adelson School of Medicine Ariel University 3 , ,","place":["Ariel, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon D","family":"Cohen","sequence":"additional","affiliation":[{"name":"Clalit Health Services 2 , ,","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Comaneshter","sequence":"additional","affiliation":[{"name":"Clalit Health Services 2 , ,","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Beckenstein","sequence":"additional","affiliation":[{"name":"Clalit Health Services 2 , ,","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit","family":"Yaron","sequence":"additional","affiliation":[{"name":"Schneider Children\u2019s Medical Center of Israel, Petach Tikva and Siaal Research Center for Family Medicine and Primary Care, Department of Family Medicine, Faculty of Health Sciences, Ben Gurion University of the Negev 4 , ,","place":["Beer Sheva, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaina","family":"Adnan","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Clalit Health Services, Haifa and Western Galilee District, and Department of Endocrinology, Azrieli Faculty of Medicine, Bar Ilan University 5 , ,","place":["Safed, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Rudman","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, and School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University 1 , ,","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiba Masri","family":"Iraqi","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, and School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University 1 , ,","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Shimon","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Rabin Medical Center \u2013 Beilinson Hospital, Petach Tikva, and School of Medicine, Faculty of Medical and Health Sciences, Tel 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