{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:20:43Z","timestamp":1783592443203,"version":"3.55.0"},"reference-count":49,"publisher":"Bioscientifica","issue":"5","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":355,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Paragangliomas (PGLs) are neuroendocrine tumours (NETs) that arise from neural crest-derived cells. Up to 40% of cases occur due to the presence of a pathogenic germline variant (PGV) in a known gene. Mediastinal PGLs are rare but are being diagnosed with increasing frequency. Treatment generally involves surgery but is complicated in mediastinal PGLs due to their anatomy. Here, we will perform a literature review and discuss our experience with 18 such cases. Cases were identified via the Guy\u2019s and St Thomas\u2019 NHS Foundation Trust NET multidisciplinary team database. Tumours ranged in size from 0.6 \u00d7 0.6 to 6.8 \u00d7 4.9 cm. 72.2% were associated with a PGV of SDHB or SDHD. 22.2% developed metastatic disease, but it was only possible to attribute 50% of these to a mediastinal primary. 68Ga-DOTATATE PET CT demonstrated 100% sensitivity. The literature review identified 233 cases. A PGV was reported in 81% of cases, with metastatic disease in approximately 39.2%. It was not possible to confirm that all cases of metastatic disease were secondary to a mediastinal primary. Our experience confirms the high rate of mediastinal PGLs arising in the presence of a PGV. The lower rate of metastatic disease in our cohort (11.1%) likely represents earlier diagnosis thanks to the application of screening protocols and the increased sensitivity of 68Ga-DOTATATE PET CT. With this increased sensitivity, we have diagnosed small mediastinal PGLs that were not evident on alternative imaging modalities. In the absence of growth or catecholamine secretion, the need to intervene on these is unclear.<\/jats:p>","DOI":"10.1530\/erc-24-0279","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T11:13:48Z","timestamp":1741605228000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":3,"title":["Clinical, genetic, radiological characteristics and management of mediastinal paragangliomas: a literature review and case series"],"prefix":"10.1530","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7271-5185","authenticated-orcid":true,"given":"Mark","family":"Quinn","sequence":"first","affiliation":[{"name":"Departments of Endocrinology, Radiology, Nuclear Medicine, Cardio-Thoracic Surgery, Genetics, Endocrine Surgery and ENT, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Kemkem","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Radiology, Nuclear Medicine, Cardio-Thoracic Surgery, Genetics, Endocrine Surgery and ENT, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"White","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Radiology, Nuclear Medicine, Cardio-Thoracic Surgery, Genetics, Endocrine Surgery and ENT, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Touska","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Radiology, Nuclear Medicine, Cardio-Thoracic Surgery, Genetics, Endocrine Surgery and ENT, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Radiology, Nuclear Medicine, Cardio-Thoracic Surgery, Genetics, Endocrine Surgery and ENT, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Jacques","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Radiology, Nuclear Medicine, Cardio-Thoracic Surgery, Genetics, Endocrine Surgery and ENT, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Breen","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Radiology, Nuclear Medicine, Cardio-Thoracic Surgery, Genetics, Endocrine Surgery and ENT, Guy\u2019s and St 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Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Harrison-Phipps","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Radiology, Nuclear Medicine, Cardio-Thoracic Surgery, Genetics, Endocrine Surgery and ENT, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathan G","family":"Hubbard","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Radiology, Nuclear Medicine, Cardio-Thoracic Surgery, Genetics, Endocrine Surgery and ENT, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Obholzer","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Radiology, Nuclear Medicine, Cardio-Thoracic Surgery, Genetics, Endocrine Surgery and ENT, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1258-4843","authenticated-orcid":true,"given":"Louise","family":"Izatt","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Radiology, Nuclear Medicine, Cardio-Thoracic Surgery, Genetics, Endocrine Surgery and ENT, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Carroll","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Radiology, Nuclear Medicine, Cardio-Thoracic Surgery, Genetics, Endocrine Surgery and ENT, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Velusamy","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Radiology, Nuclear Medicine, Cardio-Thoracic Surgery, Genetics, Endocrine Surgery and ENT, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , ,","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"2026070905472116600_bib1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41574-021-00492-3","article-title":"International consensus on initial screening and follow-up of asymptomatic SDHx mutation carriers","volume":"17","author":"Amar","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"2026070905472116600_bib2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/jmedgenet-2017-105127","article-title":"Tumour risks and genotype\u2013phenotype correlations associated with 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