{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:20:22Z","timestamp":1783592422421,"version":"3.55.0"},"reference-count":15,"publisher":"Bioscientifica","issue":"9","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The incidence of follicular thyroid carcinoma (FTC) and oncocytic carcinoma of the thyroid has seldom been studied. However, thyroid cancer incidence has experienced significant increases globally over recent decades. This study aims to investigate the incidence of FTC and oncocytic carcinoma of the thyroid in Australia with particular attention to the impact of changes in the World Health Organization (WHO) endocrine tumour classification. Using incidence data from the Australian Institute of Health and Welfare cancer registry (spanning 1982\u20132019), this descriptive epidemiological study employed joinpoint regression analysis to assess temporal trends in FTC and oncocytic carcinoma of the thyroid. Results were then compared with WHO endocrine tumour classification changes over the same period to identify potential impact(s). FTC and oncocytic carcinoma of the thyroid accounted for 9.4 and 3.2% respectively, of all thyroid carcinomas. Oncocytic carcinoma of the thyroid incidence steadily increased across the study period. Subtype analysis of FTC showed the incidence of widely invasive FTC initially increased significantly before declining and was found to affect older adults primarily. On the other hand, minimally invasive FTC incidence rose sharply for both sexes. Encapsulated angioinvasive FTC, a recently classified subtype, was found predominantly in younger age groups, particularly the 30\u201334 age bracket. Changes in the incidence of FTC and oncocytic thyroid carcinoma are noted to be influenced by classification updates. To conclude, there is a steady rise in Australian FTC and oncocytic carcinoma of the thyroid incidence, influenced to some degree by WHO classification changes.<\/jats:p>","DOI":"10.1530\/erc-24-0326","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T11:53:02Z","timestamp":1754999582000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":0,"title":["Rising incidence of follicular thyroid carcinoma and oncocytic carcinoma of the thyroid in Australia"],"prefix":"10.1530","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4697-6351","authenticated-orcid":true,"given":"Steven","family":"Weller","sequence":"first","affiliation":[{"name":"School of Medicine and Dentistry, Griffith University 1 , , ,","place":["Gold Coast, Queensland, Australia"]},{"name":"Oceania Radiofrequency Scientific Advisory Association Inc. (ORSAA) 2 , , ,","place":["Scarborough, Queensland, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3683-5638","authenticated-orcid":true,"given":"Cordia","family":"Chu","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, Griffith University 1 , , ,","place":["Gold Coast, Queensland, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2771-564X","authenticated-orcid":true,"given":"Alfred King-Yin","family":"Lam","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, Griffith University 1 , , ,","place":["Gold Coast, Queensland, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"2026070905460200800_bib1","volume-title":"Population pyramid","author":"Australian Bureau of Statistics","year":"2024"},{"key":"2026070905460200800_bib2","volume-title":"Cancer data in Australia","author":"Australian Institute of Health and Welfare","year":"2023"},{"key":"2026070905460200800_bib4","first-page":"1","article-title":"Circulating tumor cells in minimally invasive follicular thyroid carcinoma and benign thyroid tumors with a follicular pattern: pilot experience","volume":"14","author":"Badulescu","year":"2018","journal-title":"Acta Endocrinol"},{"key":"2026070905460200800_bib6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3803\/EnM.2022.1553","article-title":"Update from the 2022 World Health Organization classification of thyroid tumors: a standardized diagnostic approach","volume":"37","author":"Jung","year":"2022","journal-title":"Endocrinol Metab"},{"key":"2026070905460200800_bib7","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/pin.12737","article-title":"The new 4th edition World Health Organization classification for thyroid tumors, Asian perspectives","volume":"68","author":"Kakudo","year":"2018","journal-title":"Pathol Int"},{"key":"2026070905460200800_bib8","first-page":"209","article-title":"Pathology of endocrine tumors update: World Health Organization new classification 2017 \u2013 other thyroid tumors","volume":"22","author":"Lam","year":"2017","journal-title":"AJSP Rev Rep"},{"key":"2026070905460200800_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-1-0716-2505-7_7","volume-title":"Papillary Thyroid Carcinoma: Methods and Protocols","author":"Lam","year":"2022"},{"key":"2026070905460200800_bib10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1385\/EP:16:4:323","article-title":"Papillary carcinoma of thyroid: a 30-year clinicopathological review of the histological variants","volume":"16","author":"Lam","year":"2005","journal-title":"Endocr Pathol"},{"key":"2026070905460200800_bib11","first-page":"92","volume-title":"WHO Classification of Tumours of Endocrine Organs","author":"LiVolsi","year":"2017","edition":"4th"},{"key":"2026070905460200800_bib12","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/01.sla.0000186421.30982.d2","article-title":"Follicular thyroid carcinoma: the role of histology and staging systems in predicting survival","volume":"242","author":"Lo","year":"2005","journal-title":"Ann Surg"},{"key":"2026070905460200800_bib13","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/thy.2021.0662","article-title":"Thyroid cancer incidence and mortality trends in the United States: 2000\u20132018","volume":"32","author":"Megwalu","year":"2022","journal-title":"Thyroid"},{"key":"2026070905460200800_bib14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12957-015-0612-8","article-title":"Follicular thyroid carcinoma: differences in clinical relevance between minimally invasive and widely invasive tumors","volume":"13","author":"Podda","year":"2015","journal-title":"World J Surg Oncol"},{"key":"2026070905460200800_bib5","first-page":"67","volume-title":"WHO World Health Organization Classification of Tumours; 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