{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:39Z","timestamp":1787022819816,"version":"build-2736575974"},"reference-count":41,"publisher":"Bioscientifica","issue":"7","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We previously reported an increase in overall cancer risk in patients with endogenous Cushing\u2019s syndrome (CS), mainly during the 10-year period following CS diagnosis. To identify predictors of cancer in patients with CS, we conducted this retrospective nationwide cohort study of patients with CS, diagnosed between 2000 and 2023 in Israel. The cohort comprised 609 patients with CS (age at diagnosis, 48.1 \u00b1 17.2 years; 65.0% women) and 3,018 age-, sex-, socioeconomic status-, and body mass index-matched controls (1:5 ratio). Patients were grouped according to the occurrence of any malignancy within 10-years after the diagnosis of CS. Cox proportional hazards models, with death as a competing event, were used to identify predictors of cancer development. Independent predictors of cancer development in patients with CS included age \u226560 years (HR 1.75, 95% CI 1.01\u20132.68), male gender (HR 1.67, 95% CI 1.04\u20133.05), and adrenal-origin CS (HR 1.66, 95% CI 1.01\u20132.73). Baseline urinary-free cortisol levels were not associated with cancer development. Patients with \u22654 CS-associated comorbidities had a higher cancer risk (HR 1.76, 95% CI 1.03\u20133.02; age- and sex-adjusted). The overall 10-year risk of malignancy was twice as high in patients with CS compared to matched controls, with cancer developing, on average, 5 years earlier in patients with CS (62.3 \u00b1 15.0 vs 67.2 \u00b1 12.3 years). Cancer-related mortality at 10-years was twice as high in deceased patients with CS, compared to deceased controls. In conclusion, age \u226560 years at CS diagnosis, male gender, and adrenal-origin CS are independent predictors of cancer diagnosis within 10-years of initial confirmation of CS.<\/jats:p>","DOI":"10.1530\/erc-25-0059","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T10:50:28Z","timestamp":1749466228000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":2,"title":["Predictors of cancer in patients with endogenous Cushing\u2019s syndrome"],"prefix":"10.1530","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-6321","authenticated-orcid":true,"given":"Yaron","family":"Rudman","sequence":"first","affiliation":[{"name":"Institute of Endocrinology, Beilinson Hospital, Rabin Medical Center 1 , ,","place":["Petah Tikva, Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel Aviv University 2 , ,","place":["Tel Aviv, 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Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7576-8327","authenticated-orcid":true,"given":"Tzippy","family":"Shochat","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Rabin Medical Center, Beilinson Hospital 4 , ,","place":["Petah Tikva, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2359-5249","authenticated-orcid":true,"given":"Shiri","family":"Kushnir","sequence":"additional","affiliation":[{"name":"Research Authority, Rabin Medical Center, Beilinson Hospital 5 , ,","place":["Petah Tikva, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-3894","authenticated-orcid":true,"given":"Ilan","family":"Shimon","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Beilinson Hospital, Rabin Medical Center 1 , ,","place":["Petah Tikva, Israel"]},{"name":"Faculty of Medical and 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