{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:57:07Z","timestamp":1787065027215,"version":"build-2736575974"},"reference-count":56,"publisher":"Bioscientifica","issue":"8","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                    <jats:p\/>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Thyroid cancer is the most prevalent type of endocrine malignancy. Papillary thyroid carcinoma represents the majority of cases and is curable in approximately 90% of them, but it may also progress to anaplastic thyroid cancer, which has a poor prognosis. Therefore, the identification of new therapeutic targets remains essential. In clinical practice, HO-1 mRNA is used as a biomarker to predict malignancy in thyroid nodules. However, its role in thyroid tumor progression remains understudied, as well as its potential as a therapeutic target. In this work, we confirmed that HO-1 protein is increased in human papillary thyroid cancer tissues and further demonstrated that high HO-1 mRNA is associated with progression to anaplastic thyroid cancer. Through pharmacological modulation of human papillary and anaplastic thyroid cells, and by genetically overexpressing HO-1 variants in papillary thyroid cells, we demonstrated that the overexpression of enzymatically active HO-1 enhances cell proliferation, migration, and cell cycle progression. Finally, we demonstrated that MEK\/ERK signaling is partially involved in HO-1 effects. We concluded that HO-1 plays a relevant protumor role in thyroid cancer, and it may be a promising coadjuvant therapeutic target for papillary and anaplastic thyroid cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/erc-25-0177","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T14:23:16Z","timestamp":1753971796000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":2,"title":["Heme-oxygenase-1: a key player in thyroid carcinoma development"],"prefix":"10.1530","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-5973","authenticated-orcid":true,"given":"Exequiel Gonzalo","family":"Alonso","sequence":"first","affiliation":[{"name":"Laboratorio de Biolog\u00eda del C\u00e1ncer, Instituto de Investigaciones Bioqu\u00edmicas de Bah\u00eda Blanca (INIBIBB), Universidad Nacional del Sur (UNS)-CONICET, Dpto. de Biolog\u00eda, Bioqu\u00edmica y Farmacia (UNS) 1 , 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