{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:21:32Z","timestamp":1783606892432,"version":"3.55.0"},"reference-count":50,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>The purpose of this study is to assess the feasibility, efficacy and safety of cone-beam computed tomography (CBCT)-guided cryoablation of bone metastases in thyroid and adrenocortical cancers. Adult patients with bone metastases and at least 1 skeletal-related event (pain, risk of fracture, spinal cord compression or hypercalcemia) at baseline were enrolled in a prospective, single-arm, single-center IRB-approved study (ClinicalTrials: NCT03986593). Brief Pain Inventory \u2013 Short Form (BPI-SF) and morphine-equivalent daily dose (M-EDD) were recorded at baseline and weekly during the first 8 weeks and 3, 6, 12 and 24 months post-cryoablation. Adverse events (AEs) and pre- and post-treatment cross-sectional (CT or MR) and functional imaging with PET\/CT were analyzed. Seventeen patients (mean age of 58.3 \u00b1 16.2 years old; 11 women) with either differentiated (n = 8; 47.1%) or medullary thyroid cancer (n = 6; 35.6%), or adrenocortical cancer (n = 3; 17.3%) were enrolled. CBCT-guided cryoablation of 24 bone metastases reached 100% technical success rate. An overall drop of 4.8 points (P &amp;lt; 0.05) in the worst pain in the last 24 h and M-EDD overall intake decrease (P &amp;lt; 0.05) were observed. In addition to pain improvement, no patients required surgery. Three patients (17.6%) required radiotherapy due to refractory or recurrent pain over a follow-up of 14.9 \u00b1 14.0 (median \u00b1 IQR) months. No grade 4 or 5 AE was reported. One grade 3 AE (5.9%) and two grade 2 AEs (11.8%) occurred. PET\/CT imaging showed a 52% reduction in FDG uptake immediately after cryoablation. Cryoablation of bone metastases in thyroid and adrenocortical cancers was safe and effective, providing rapid and long-lasting pain relief and improving quality of life.<\/jats:p>\n                    <jats:p>ClinicalTrials.gov: NCT 03986593.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance statements<\/jats:title>\n                    <jats:p>Cryoablation led to a sustained reduction in pain with a mean improvement of 7.2 points on a 1\u201310 scale of the Brief Pain Inventory \u2013 Short Form (BPI-SF) after 54 weeks. Pain relief and quality-of-life improvement (assessed by the BPI-SF) were observed in 81.3% of bone metastases just one week after cryoablation with an overall pain score reduction of 4.8 points. Cryoablation of bone metastases from endocrine cancers was safe and effective, providing long-lasting pain relief.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/erc-25-0306","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:26:43Z","timestamp":1768566403000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":0,"title":["Cryoablation of bone metastases in thyroid and adrenocortical cancers"],"prefix":"10.1530","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8836-1422","authenticated-orcid":true,"given":"Ricardo Miguel Costa","family":"de Freitas","sequence":"first","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Oliveira","family":"Hoff","sequence":"additional","affiliation":[{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Candida Barisson Villares","family":"Fragoso","sequence":"additional","affiliation":[{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Maria","family":"Sousa","sequence":"additional","affiliation":[{"name":"4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-8027","authenticated-orcid":true,"given":"Debora Lucia Seguro","family":"Danilovic","sequence":"additional","affiliation":[{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Audi","family":"de Castroneves","sequence":"additional","affiliation":[{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Ramos","family":"Grigio","sequence":"additional","affiliation":[{"name":"4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam Harumi","family":"Tsunemi","sequence":"additional","affiliation":[{"name":"5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos 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