{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:22:40Z","timestamp":1783606960460,"version":"3.55.0"},"reference-count":66,"publisher":"Bioscientifica","issue":"6","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>Papillary thyroid carcinoma (PTC) is the most prevalent type of thyroid malignancy, where invasive growth and distant metastasis contribute to a worsened patient prognosis. SPARCL1, a known tumor suppressor gene in various cancers, encodes a secreted glycoprotein. Preliminary research suggests that elevated expression of SPARCL1 is correlated with a better prognosis in PTC, highlighting its potential as an innovative restorative therapeutic agent, but its specific role and underlying mechanisms remain unclear. This study aimed to investigate the impact of SPARCL1 on the invasion and metastasis of PTC cells by constructing an overexpression model of SPARCL1 in PTC cells through viral transduction, collecting the supernatant proteins from the PTC cell model and adding them to PTC cells, and introducing recombinant SPARCL1 protein into PTC cells. In addition, we conducted animal experiments to detect the effects of SPARCL1 on the subcutaneous tumor formation and multi-organ metastasis of PTC cells in mice, as well as the inhibitory effect of recombinant SPARCL1 on tumors formed by PTC cells. The findings revealed that overexpression of the SPARCL1 gene, the secretory form of the SPARCL1 protein, and the recombinant SPARCL1 protein all significantly inhibited the malignant biological behaviors of PTC cells. Overexpression of SPARCL1 can inhibit the subcutaneous growth of tumor cells and their metastasis to the lungs, liver, and kidneys of mice, and recombinant SPARCL1 protein can also inhibit the growth of subcutaneous tumors. Mechanistically, SPARCL1 appears to mediate its anti-tumor effects through the SLC3A2-mediated ferroptosis pathway, suggesting a novel mechanism by which SPARCL1 influences PTC progression. In summary, SPARCL1 inhibits the proliferation, invasion, and metastasis of PTC, highlighting its potential as a candidate for innovative restorative therapies in PTC treatment.<\/jats:p>","DOI":"10.1530\/erc-26-0018","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:31:16Z","timestamp":1779298276000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":0,"title":["The secreted protein SPARCL1 suppresses tumor progression in papillary thyroid carcinoma via SLC3A2-mediated ferroptosis"],"prefix":"10.1530","volume":"33","author":[{"given":"Fengping","family":"Wu","sequence":"first","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinkang","family":"Zhang","sequence":"additional","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongkun","family":"Xu","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanghua","family":"Cheng","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Gan","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Ren","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haocheng","family":"Yang","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"1"},{"name":"2"},{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuliang","family":"Xia","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Jiang","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Shi","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8100-8511","authenticated-orcid":true,"given":"Wenling","family":"Tu","sequence":"additional","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"2026070909475311700_bib1","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/S0140-6736(16)30172-6","article-title":"Thyroid cancer","volume":"388","author":"Cabanillas","year":"2016","journal-title":"Lancet"},{"key":"2026070909475311700_bib2","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1056\/NEJMra1501993","article-title":"Biologic and clinical perspectives on thyroid cancer","volume":"375","author":"Fagin","year":"2016","journal-title":"N Engl J Med"},{"key":"2026070909475311700_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"2026070909475311700_bib4","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.3390\/cancers14153677","article-title":"Central lymph node ratio predicts recurrence in patients with N1b papillary thyroid carcinoma","volume":"14","author":"Kang","year":"2022","journal-title":"Cancers"},{"key":"2026070909475311700_bib5","doi-asserted-by":"crossref","DOI":"10.1530\/ERC-25-0420","article-title":"Defining the ATA-2025 \u201cconsider RAIT\u201d zone in older patients with N1b PTC","volume":"33","author":"Wang","year":"2026","journal-title":"Endocr Relat Cancer"},{"key":"2026070909475311700_bib6","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.3390\/cancers14102461","article-title":"Looking at thyroid cancer from the tumor-suppressor genes point of view","volume":"14","author":"Rajabi","year":"2022","journal-title":"Cancers"},{"key":"2026070909475311700_bib7","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a003236","article-title":"Oncogenes and tumor suppressor genes","volume":"2","author":"Lee","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026070909475311700_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.582","article-title":"Oncogenes and tumor suppressor genes: functions and roles in cancers","volume":"5","author":"Dakal","year":"2024","journal-title":"MedComm"},{"key":"2026070909475311700_bib9","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1158\/0008-5472.CAN-15-1395","article-title":"Breast cancer tumor suppressors: a special emphasis on novel protein nischarin","volume":"75","author":"Maziveyi","year":"2015","journal-title":"Cancer Res"},{"key":"2026070909475311700_bib10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41419-025-07702-0","article-title":"Prolyl 4-hydroxylase subunit alpha-2 acts as a TRIM21 ubiquitination substrate to promote papillary thyroid cancer progression via the glycolytic pathway","volume":"16","author":"Wu","year":"2025","journal-title":"Cell Death Dis"},{"key":"2026070909475311700_bib11","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1038\/onc.2015.253","article-title":"TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer","volume":"35","author":"Zou","year":"2016","journal-title":"Oncogene"},{"key":"2026070909475311700_bib12","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/gcc.22162","article-title":"Variants in the ATM-CHEK2-BRCA1 axis determine genetic predisposition and clinical presentation of papillary thyroid carcinoma","volume":"53","author":"W\u00f3jcicka","year":"2014","journal-title":"Genes Chromosomes Cancer"},{"key":"2026070909475311700_bib13","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1093\/jnci\/djt249","article-title":"Identification of RASAL1 as a major tumor suppressor gene in thyroid cancer","volume":"105","author":"Liu","year":"2013","journal-title":"J Natl Cancer Inst"},{"key":"2026070909475311700_bib14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1089\/thy.2006.16.17","article-title":"PTEN promoter methylation in sporadic thyroid carcinomas","volume":"16","author":"Alvarez-Nu\u00f1ez","year":"2006","journal-title":"Thyroid"},{"key":"2026070909475311700_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/537S63a","article-title":"Perspective: the precision-oncology illusion","volume":"537","author":"Prasad","year":"2016","journal-title":"Nature"},{"key":"2026070909475311700_bib16","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1056\/NEJMsb1607705","article-title":"Limits to personalized cancer medicine","volume":"375","author":"Tannock","year":"2016","journal-title":"N Engl J Med"},{"key":"2026070909475311700_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn9155","article-title":"Diverse rescue potencies of p53 mutations to ATO are predetermined by intrinsic mutational properties","volume":"15","author":"Song","year":"2023","journal-title":"Sci Transl Med"},{"key":"2026070909475311700_bib18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13148-023-01622-6","article-title":"Long non-coding RNA ACTA2-AS1 suppresses metastasis of papillary thyroid cancer via regulation of miR-4428\/KLF9 axis","volume":"16","author":"Wu","year":"2024","journal-title":"Clin Epigenetics"},{"key":"2026070909475311700_bib19","doi-asserted-by":"crossref","first-page":"6434","DOI":"10.7150\/jca.98470","article-title":"IPCEF1: expression patterns, clinical correlates and new target of papillary thyroid carcinoma","volume":"15","author":"Yin","year":"2024","journal-title":"J Cancer"},{"key":"2026070909475311700_bib20","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1158\/0008-5472.CAN-17-3766","article-title":"Long noncoding RNA AB074169 inhibits cell proliferation via modulation of KHSRP-mediated CDKN1a expression in papillary thyroid carcinoma","volume":"78","author":"Gou","year":"2018","journal-title":"Cancer Res"},{"key":"2026070909475311700_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.857765","article-title":"FTO prevents thyroid cancer progression by SLC7A11 m6A methylation in a ferroptosis-dependent manner","volume":"13","author":"Ji","year":"2022","journal-title":"Front Endocrinol"},{"key":"2026070909475311700_bib22","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144801","article-title":"Sparcl1 promotes nonalcoholic steatohepatitis progression in mice through upregulation of CCL2","volume":"131","author":"Liu","year":"2021","journal-title":"J Clin Investig"},{"key":"2026070909475311700_bib23","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jot.2024.02.009","article-title":"SPARCL1 promotes chondrocytes extracellular matrix degradation and inflammation in osteoarthritis via TNF\/NF-\u03baB pathway","volume":"46","author":"Miao","year":"2024","journal-title":"J Orthop Translat"},{"key":"2026070909475311700_bib24","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.2147\/JIR.S406907","article-title":"Sparcl1 and atherosclerosis","volume":"16","author":"Cheng","year":"2023","journal-title":"J Inflamm Res"},{"key":"2026070909475311700_bib25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/1074-7613(95)90083-7","article-title":"Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC","volume":"2","author":"Girard","year":"1995","journal-title":"Immunity"},{"key":"2026070909475311700_bib26","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/s41416-022-01728-3","article-title":"The KDM6A-SPARCL1 axis blocks metastasis and regulates the tumour microenvironment of gastrointestinal stromal tumours by inhibiting the nuclear translocation of p65","volume":"126","author":"Shen","year":"2022","journal-title":"Br J Cancer"},{"key":"2026070909475311700_bib27","first-page":"521","article-title":"Genomic organization and chromosomal mapping of SPARC-like 1, a gene down regulated in cancers","volume":"18","author":"Isler","year":"2001","journal-title":"Int J Oncol"},{"key":"2026070909475311700_bib28","first-page":"2331","article-title":"Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung","volume":"57","author":"Petersen","year":"1997","journal-title":"Cancer Res"},{"key":"2026070909475311700_bib29","first-page":"17","article-title":"Deletions of chromosome 4 at multiple sites are frequent in malignant mesothelioma and small cell lung carcinoma","volume":"5","author":"Shivapurkar","year":"1999","journal-title":"Clin Cancer Res"},{"key":"2026070909475311700_bib30","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/bjc.1998.583","article-title":"Chromosome alterations in breast carcinomas: frequent involvement of DNA losses including chromosomes 4q and 21q","volume":"78","author":"Schwendel","year":"1998","journal-title":"Br J Cancer"},{"key":"2026070909475311700_bib31","first-page":"5213","article-title":"Partial allelotype of carcinoma in situ of the human bladder","volume":"55","author":"Rosin","year":"1995","journal-title":"Cancer Res"},{"key":"2026070909475311700_bib32","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/(SICI)1097-0215(19961220)69:6<442::AID-IJC3>3.0.CO;2-4","article-title":"An allelotype of papillary thyroid cancer","volume":"69","author":"Califano","year":"1996","journal-title":"Int J Cancer"},{"key":"2026070909475311700_bib33","article-title":"Identifying liver metastasis-related hub genes in breast cancer and characterizing SPARCL1 as a potential prognostic biomarker","volume":"11","author":"Chen","year":"2023","journal-title":"PeerJ"},{"key":"2026070909475311700_bib34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10616-020-00443-2","article-title":"The inhibition of HeLa cells proliferation through SPARCL1 mediated by SPP1","volume":"73","author":"Zhang","year":"2021","journal-title":"Cytotechnology"},{"key":"2026070909475311700_bib35","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1158\/0008-5472.CAN-15-0024","article-title":"Androgen-regulated SPARCL1 in the tumor microenvironment inhibits metastatic progression","volume":"75","author":"Hurley","year":"2015","journal-title":"Cancer Res"},{"key":"2026070909475311700_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110606","article-title":"Construction of an immune-related lncRNA-miRNA-mRNA regulatory network in radiation-induced esophageal injury in rats","volume":"122","author":"Wu","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"2026070909475311700_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-23906-2","article-title":"Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer","volume":"12","author":"Sekhar","year":"2022","journal-title":"Sci Rep"},{"key":"2026070909475311700_bib38","article-title":"Clinicopathological features affecting the efficacy in 131I ablation therapy of papillary thyroid carcinoma with lymph node metastasis","volume":"15","author":"Xu","year":"2024","journal-title":"Front Endocrinol"},{"key":"2026070909475311700_bib39","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1177\/000313480507100907","article-title":"The implication of lymph node metastasis on survival in patients with well-differentiated thyroid cancer","volume":"71","author":"Podnos","year":"2005","journal-title":"Am Surg"},{"key":"2026070909475311700_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/pore.2022.1610687","article-title":"Immunological role and prognostic value of SPARCL1 in pan-cancer analysis","volume":"28","author":"He","year":"2022","journal-title":"Pathol Oncol Res"},{"key":"2026070909475311700_bib41","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.molonc.2013.07.008","article-title":"SPARCL1 suppresses metastasis in prostate cancer","volume":"7","author":"Xiang","year":"2013","journal-title":"Mol Oncol"},{"key":"2026070909475311700_bib42","doi-asserted-by":"crossref","first-page":"14977","DOI":"10.1073\/pnas.1203525109","article-title":"Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome","volume":"109","author":"Hurley","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026070909475311700_bib43","doi-asserted-by":"crossref","first-page":"7784","DOI":"10.3892\/mmr.2017.7535","article-title":"SPARCL1 suppresses cell migration and invasion in renal cell carcinoma","volume":"16","author":"Ye","year":"2017","journal-title":"Mol Med Rep"},{"key":"2026070909475311700_bib44","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1158\/1078-0432.CCR-12-0124","article-title":"Secreted protein acidic and rich in cysteines-like 1 suppresses aggressiveness and predicts better survival in colorectal cancers","volume":"18","author":"Hu","year":"2012","journal-title":"Clin Cancer Res"},{"key":"2026070909475311700_bib45","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12876-018-0833-8","article-title":"Secreted protein acidic and rich in cysteine-like 1 suppresses metastasis in gastric stromal tumors","volume":"18","author":"Shen","year":"2018","journal-title":"BMC Gastroenterol"},{"key":"2026070909475311700_bib46","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.7150\/ijbs.82361","article-title":"PTPLAD1 regulates PHB-Raf interaction to orchestrate epithelial-mesenchymal and Mitofusion-Fission transitions in colorectal cancer","volume":"20","author":"Huang","year":"2024","journal-title":"Int J Biol Sci"},{"key":"2026070909475311700_bib47","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1158\/1535-7163.MCT-19-0536","article-title":"An orally available tubulin inhibitor, VERU-111, suppresses triple-negative breast cancer tumor growth and metastasis and bypasses taxane resistance","volume":"19","author":"Deng","year":"2020","journal-title":"Mol Cancer Ther"},{"key":"2026070909475311700_bib48","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/path.2068","article-title":"SPARC and Hevin expression correlate with tumour angiogenesis in hepatocellular carcinoma","volume":"210","author":"Lau","year":"2006","journal-title":"J Pathol"},{"key":"2026070909475311700_bib49","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1093\/ibd\/izaa346","article-title":"Matricellular protein SPARCL1 regulates blood vessel integrity and antagonizes inflammatory bowel disease","volume":"27","author":"Regensburger","year":"2021","journal-title":"Inflamm Bowel Dis"},{"key":"2026070909475311700_bib50","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.7150\/jca.95501","article-title":"TLE4 downregulation identified by WGCNA and machine learning algorithm promotes papillary thyroid carcinoma progression via activating JAK\/STAT pathway","volume":"15","author":"Lin","year":"2024","journal-title":"J Cancer"},{"key":"2026070909475311700_bib51","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12935-023-03033-2","article-title":"Progranulin promoted the proliferation, metastasis, and suppressed apoptosis via JAK2-STAT3\/4 signaling pathway in papillary thyroid carcinoma","volume":"23","author":"Dong","year":"2023","journal-title":"Cancer Cell Int"},{"key":"2026070909475311700_bib52","doi-asserted-by":"crossref","first-page":"E2361","DOI":"10.1073\/pnas.1201232109","article-title":"STAT3 negatively regulates thyroid tumorigenesis","volume":"109","author":"Couto","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026070909475311700_bib53","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00018-024-05348-3","article-title":"Suppression of Skp2 contributes to sepsis-induced acute lung injury by enhancing ferroptosis through the ubiquitination of SLC3A2","volume":"81","author":"Chen","year":"2024","journal-title":"Cell Mol Life Sci"},{"key":"2026070909475311700_bib54","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"2026070909475311700_bib55","article-title":"Regulated cell death in glioma: promising targets for natural small-molecule compounds","volume":"14","author":"Han","year":"2024","journal-title":"Front Oncol"},{"key":"2026070909475311700_bib56","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat Chem Biol"},{"key":"2026070909475311700_bib57","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.bbalip.2013.10.018","article-title":"Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol","volume":"1841","author":"K\u00fcch","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"2026070909475311700_bib58","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3181\/0710-MR-287","article-title":"Mammalian long-chain Acyl-CoA synthetases","volume":"233","author":"Soupene","year":"2008","journal-title":"Exp Biol Med"},{"key":"2026070909475311700_bib59","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.3390\/cancers14235896","article-title":"ACSL3 and ACSL4, distinct roles in ferroptosis and cancers","volume":"14","author":"Yang","year":"2022","journal-title":"Cancers"},{"key":"2026070909475311700_bib60","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2008.07.005","article-title":"Glutathione peroxidase 4 senses and translates oxidative stress into 12\/15-lipoxygenase dependent- and AIF-mediated cell death","volume":"8","author":"Seiler","year":"2008","journal-title":"Cell Metab"},{"key":"2026070909475311700_bib61","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine\u2013glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"Elife"},{"key":"2026070909475311700_bib62","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nrcardio.2016.20","article-title":"Coronary artery disease: can aminothiols be distinguished from reactive oxygen species?","volume":"13","author":"Rochette","year":"2016","journal-title":"Nat Rev Cardiol"},{"key":"2026070909475311700_bib63","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"2026070909475311700_bib64","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.7150\/thno.87968","article-title":"Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE\u2212\/\u2212mice","volume":"13","author":"Xiang","year":"2023","journal-title":"Theranostics"},{"key":"2026070909475311700_bib65","article-title":"Transsulfuration is a significant source of sulfur for glutathione production in human mammary epithelial cells","volume":"2013","author":"Belalc\u00e1zar","year":"2014","journal-title":"ISRN Biochem"},{"key":"2026070909475311700_bib66","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1089\/dna.2021.0216","article-title":"The knockdown of ETV4 inhibits the papillary thyroid cancer development by promoting ferroptosis upon SLC7A11 downregulation","volume":"40","author":"Wang","year":"2021","journal-title":"DNA Cell Biol"}],"container-title":["Endocrine-Related Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/33\/6\/ERC-26-0018.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/33\/6\/ERC-26-0018.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/doi\/10.1530\/ERC-26-0018\/520337\/erc-26-0018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/doi\/10.1530\/ERC-26-0018\/520337\/erc-26-0018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:48:07Z","timestamp":1783604887000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article\/33\/6\/e260018\/77632\/The-secreted-protein-SPARCL1-suppresses-tumor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.1530\/erc-26-0018","relation":{},"ISSN":["1479-6821","1351-0088"],"issn-type":[{"value":"1479-6821","type":"electronic"},{"value":"1351-0088","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"article-number":"e260018"}}