{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:23:14Z","timestamp":1788268994361,"version":"build-2803163510"},"reference-count":58,"publisher":"Bioscientifica","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Papillary thyroid cancer (PTC) is less aggressive when associated with lymphocytic thyroiditis (LT), even in the presence of oncogenic BRAF, including smaller tumours, less lymph node involvement and reduced extrathyroidal extension. To investigate possible immune mechanisms underlying this association, we compared the tumour microenvironment of PTC-BRAF with LT and that without LT using single-cell RNA sequencing (scRNA-seq). Single-cell libraries were generated from fresh and fixed tumour samples with post-dissociation viability &amp;gt;70% using the 10x Genomics Chromium Platform and sequenced on an Illumina NovaSeq 6000. We analysed scRNA-seq data from 11 PTC-BRAF tumours: four with LT (one publicly available sample) and seven without LT. Downstream analyses included quality control, batch correction, dimensionality reduction, and differential gene expression analysis. We found that neutrophils were the predominant myeloid cell type in PTCs without LT. Thyrocytes without LT showed significant expression of the neutrophil recruitment chemokine ECRG4. In the absence of LT, neutrophils expressed oncogenic genes with poor clinical outcomes. In contrast, thyrocytes from tumours with LT showed increased expression of MHC-II antigen presentation, consistent with effective immune surveillance. Thyrocytes and macrophages in the presence of LT showed enrichment of interferon gamma response pathways. Our data suggest that LT in thyroid cancer is associated with enhanced antigen presentation and fewer features of pro-tumourigenic innate immune activity. These results identify previously under-recognised innate immune cell population and associated transcriptomic features, which suggest new mechanisms to target immune treatments in PTC refractory to other therapies.<\/jats:p>","DOI":"10.1530\/erc-26-0088","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T09:35:24Z","timestamp":1786527324000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":0,"title":["Myeloid landscape of BRAF-mutant papillary thyroid cancer and thyroiditis"],"prefix":"10.1530","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7369-5937","authenticated-orcid":true,"given":"Sumathy","family":"Perampalam","sequence":"first","affiliation":[{"name":"Cancer Genetics Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Faculty of Medicine and Health, University of Sydney 1 , , ,","place":["Camperdown, New South Wales, Australia"]},{"name":"The Canberra Hospital, Department of Endocrinology 2 , , ,","place":["Canberra, Australian Capital Territory, Australia"]},{"name":"Australian National University, School of Medicine and Psychology 3 , , ,","place":["Garran, Australian Capital Territory, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Gild","sequence":"additional","affiliation":[{"name":"Cancer Genetics Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Faculty of Medicine and Health, University of Sydney 1 , , ,","place":["Camperdown, New South Wales, Australia"]},{"name":"Royal North Shore Hospital, Department of Endocrinology and Diabetes 4 , ,","place":["St Leonards, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adwoa Amoakowa","family":"Sey","sequence":"additional","affiliation":[{"name":"Cancer Genetics Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Faculty of Medicine and Health, University of Sydney 1 , , ,","place":["Camperdown, New South Wales, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndal J","family":"Tacon","sequence":"additional","affiliation":[{"name":"Cancer Genetics Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Faculty of Medicine and Health, University of Sydney 1 , , ,","place":["Camperdown, New South Wales, Australia"]},{"name":"Royal North Shore Hospital, Department of Endocrinology and Diabetes 4 , ,","place":["St Leonards, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitali","family":"Fadia","sequence":"additional","affiliation":[{"name":"Australian National University, School of Medicine and Psychology 3 , , ,","place":["Garran, Australian Capital Territory, Australia"]},{"name":"The Canberra Hospital, Department of Pathology 5 , , ,","place":["Garran, Australian Capital Territory, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0339-7932","authenticated-orcid":true,"given":"Cathal","family":"King","sequence":"additional","affiliation":[{"name":"South Australian Immunogenomics Cancer Institute (SAiGENCI), Adelaide University 6 , , ,","place":["Adelaide, South Australia, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-5963","authenticated-orcid":true,"given":"Alexander","family":"Papachristos","sequence":"additional","affiliation":[{"name":"University of Sydney Endocrine Surgery, Faculty of Medicine and Health, University of Sydney 7 , ,","place":["Camperdown, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Sywak","sequence":"additional","affiliation":[{"name":"University of Sydney Endocrine Surgery, Faculty of Medicine and Health, University of Sydney 7 , ,","place":["Camperdown, Australia"]},{"name":"Royal North Shore Hospital, Department of Endocrine Surgery 8 , ,","place":["St Leonards, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J","family":"Gill","sequence":"additional","affiliation":[{"name":"NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital 9 , , ,","place":["St Leonards, New South Wales, Australia"]},{"name":"Sydney Medical School, University of Sydney 10 , , ,","place":["Camperdown, New South Wales, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn","family":"Bullock","sequence":"additional","affiliation":[{"name":"Cancer Genetics Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Faculty of Medicine and Health, University of Sydney 1 , , ,","place":["Camperdown, New South Wales, Australia"]},{"name":"Royal North Shore Hospital, Department of Endocrinology and Diabetes 4 , ,","place":["St Leonards, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3740-5509","authenticated-orcid":true,"given":"Roderick J","family":"Clifton-Bligh","sequence":"additional","affiliation":[{"name":"Cancer Genetics Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Faculty of Medicine and Health, University of Sydney 1 , , ,","place":["Camperdown, New South Wales, Australia"]},{"name":"Royal North Shore Hospital, Department of Endocrinology and Diabetes 4 , ,","place":["St Leonards, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"2026090109063610600_bib1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/jama.2023.26348","article-title":"Thyroid cancer: a review","volume":"331","author":"Boucai","year":"2024","journal-title":"JAMA"},{"key":"2026090109063610600_bib2","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.cell.2014.09.050","article-title":"Integrated genomic characterization of papillary thyroid carcinoma","volume":"159","author":"Cancer Genome Atlas Research Network","year":"2014","journal-title":"Cell"},{"key":"2026090109063610600_bib3","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1089\/thy.2014.0134","article-title":"BRAF V600E in papillary thyroid carcinoma is associated with increased programmed death ligand 1 expression and suppressive immune cell infiltration","volume":"24","author":"Angell","year":"2014","journal-title":"Thyroid"},{"key":"2026090109063610600_bib4","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1001\/jamaoncol.2024.4729","article-title":"Anti-programmed death ligand 1 plus targeted therapy in anaplastic thyroid carcinoma: a nonrandomized clinical trial","volume":"10","author":"Cabanillas","year":"2024","journal-title":"JAMA Oncol"},{"key":"2026090109063610600_bib5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/CCO.0000000000000150","article-title":"Association of Hashimoto\u2019s thyroiditis and thyroid cancer","volume":"27","author":"Noureldine","year":"2015","journal-title":"Curr Opin Oncol"},{"key":"2026090109063610600_bib6","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.18526","article-title":"Prevalence of hashimoto thyroiditis in adults with papillary thyroid cancer and its association with cancer recurrence and outcomes","volume":"4","author":"Xu","year":"2021","journal-title":"JAMA Netw Open"},{"key":"2026090109063610600_bib7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41392-025-02280-1","article-title":"Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches","volume":"10","author":"Tufail","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"2026090109063610600_bib8","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41392-024-01765-9","article-title":"Harnessing innate immune pathways for therapeutic advancement in cancer","volume":"9","author":"Hu","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"2026090109063610600_bib9","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1089\/thy.2024.0142","article-title":"The association between lymphocytic thyroiditis and papillary thyroid cancer harboring mutant BRAF: a systematic review and meta-analysis","volume":"34","author":"Perampalam","year":"2024","journal-title":"Thyroid"},{"key":"2026090109063610600_bib10","doi-asserted-by":"crossref","first-page":"6149","DOI":"10.1038\/s41467-022-33907-4","article-title":"Reprogramming of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma","volume":"13","author":"Rabold","year":"2022","journal-title":"Nat Commun"},{"key":"2026090109063610600_bib11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/PAT.0000000000000119","article-title":"Immunohistochemistry with the anti-BRAF V600E (VE1) antibody: impact of pre-analytical conditions and concordance with DNA sequencing in colorectal and papillary thyroid carcinoma","volume":"46","author":"Dvorak","year":"2014","journal-title":"Pathology"},{"key":"2026090109063610600_bib13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00011-016-0995-1","article-title":"The biological function and significance of CD74 in immune diseases","volume":"66","author":"Su","year":"2017","journal-title":"Inflamm Res"},{"key":"2026090109063610600_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"2026090109063610600_bib15","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1126\/science.8016643","article-title":"Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA","volume":"265","author":"Steimle","year":"1994","journal-title":"Science"},{"key":"2026090109063610600_bib16","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1084\/jem.20112422","article-title":"Essential role of EBF1 in the generation and function of distinct mature B cell types","volume":"209","author":"Vilagos","year":"2012","journal-title":"J Exp Med"},{"key":"2026090109063610600_bib18","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1186\/s12885-022-09541-0","article-title":"LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT\/mTOR pathway","volume":"22","author":"Tan","year":"2022","journal-title":"BMC Cancer"},{"key":"2026090109063610600_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.725","article-title":"Protein phosphatase 1 regulatory inhibitor subunit 14C promotes triple-negative breast cancer progression via sustaining inactive glycogen synthase kinase 3 beta","volume":"12","author":"Jian","year":"2022","journal-title":"Clin Transl Med"},{"key":"2026090109063610600_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215882","article-title":"Carboxypeptidase E and its splice variants: key regulators of growth and metastasis in multiple cancer types","volume":"548","author":"Hareendran","year":"2022","journal-title":"Cancer Lett"},{"key":"2026090109063610600_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2025.189269","article-title":"Neuromedin U in the tumor microenvironment \u2013 possible actions in tumor progression","volume":"1880","author":"Przygodzka","year":"2025","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"2026090109063610600_bib22","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/sj.bjc.6604463","article-title":"Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype","volume":"99","author":"Elsheikh","year":"2008","journal-title":"Br J Cancer"},{"key":"2026090109063610600_bib23","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.21037\/atm-21-2062","article-title":"DAPK2 activates NF-kappaB through autophagy-dependent degradation of I-kappaBalpha during thyroid cancer development and progression","volume":"9","author":"Jiang","year":"2021","journal-title":"Ann Transl Med"},{"key":"2026090109063610600_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1536270","article-title":"Identification of novel prognostic biomarkers for thyroid cancer by integrated transcriptome analysis of metastasis-associated genes","volume":"15","author":"Alnwisser","year":"2025","journal-title":"Front Oncol"},{"key":"2026090109063610600_bib25","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s13277-014-2731-1","article-title":"The tumor-promoting function of ECRG4 in papillary thyroid carcinoma and its related mechanism","volume":"36","author":"Chen","year":"2015","journal-title":"Tumour Biol"},{"key":"2026090109063610600_bib26","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/sj.bjc.6600172","article-title":"Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid","volume":"86","author":"Ito","year":"2002","journal-title":"Br J Cancer"},{"key":"2026090109063610600_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay0518","article-title":"ECRG4 regulates neutrophil recruitment and CD44 expression during the inflammatory response to injury","volume":"6","author":"Dorschner","year":"2020","journal-title":"Sci Adv"},{"key":"2026090109063610600_bib28","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.168161","article-title":"DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer","volume":"8","author":"Li","year":"2023","journal-title":"JCI Insight"},{"key":"2026090109063610600_bib29","doi-asserted-by":"crossref","DOI":"10.1177\/15330338231218163","article-title":"COLEC12 promotes tumor progression and is correlated with poor prognosis in gastric cancer","volume":"22","author":"Sun","year":"2023","journal-title":"Technol Cancer Res Treat"},{"key":"2026090109063610600_bib30","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.4049\/jimmunol.1500493","article-title":"Soluble Collectin-12 (CL-12) is a pattern recognition molecule initiating complement activation via the alternative pathway","volume":"195","author":"Ma","year":"2015","journal-title":"J Immunol"},{"key":"2026090109063610600_bib31","article-title":"A pan-cancer analysis reveals CLEC5A as a biomarker for cancer immunity and prognosis","volume":"13","author":"Chen","year":"2022","journal-title":"Front Immunol"},{"key":"2026090109063610600_bib32","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.2147\/IJGM.S461144","article-title":"Unveiling the impact of MRC1 on immune infiltration and patient\u2019s prognosis: a pan-cancer analysis based on single-cell and bulk sequencing","volume":"17","author":"Wu","year":"2024","journal-title":"Int J Gen Med"},{"key":"2026090109063610600_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113599","article-title":"WNT5A in tumor development and progression: a comprehensive review","volume":"155","author":"Bueno","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"2026090109063610600_bib34","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.3390\/cancers15205033","article-title":"USP53 exerts tumor-promoting effects in triple-negative breast cancer by deubiquitinating CRKL","volume":"15","author":"Liu","year":"2023","journal-title":"Cancers"},{"key":"2026090109063610600_bib35","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12951-024-02456-x","article-title":"Single-sEV profiling identifies the TACSTD2 + sEV subpopulation as a factor of tumor susceptibility in the elderly","volume":"22","author":"Ning","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"2026090109063610600_bib36","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1158\/2326-6066.CIR-14-0112","article-title":"NF-kappaB, an active player in human cancers","volume":"2","author":"Xia","year":"2014","journal-title":"Cancer Immunol Res"},{"key":"2026090109063610600_bib37","article-title":"C15ORF48 serves as a potential biomarker and therapeutic target in pan-cancer with implications for lung cancer","volume":"15","author":"Ren","year":"2025","journal-title":"Sci Rep"},{"key":"2026090109063610600_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75012-w","article-title":"Comprehensive analysis of the expression of SLC30A family genes and prognosis in human gastric cancer","volume":"10","author":"Guo","year":"2020","journal-title":"Sci Rep"},{"key":"2026090109063610600_bib39","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/imm.13722","article-title":"Roles of S100A8, S100A9 and S100A12 in infection, inflammation and immunity","volume":"171","author":"Xia","year":"2024","journal-title":"Immunology"},{"key":"2026090109063610600_bib40","doi-asserted-by":"crossref","DOI":"10.1177\/03000605211008325","article-title":"FK506-binding protein 5 promotes the progression of papillary thyroid carcinoma","volume":"49","author":"Gao","year":"2021","journal-title":"J Int Med Res"},{"key":"2026090109063610600_bib41","article-title":"The role of immune cells and immune related genes in the tumor microenvironment of papillary thyroid cancer and their significance for immunotherapy","volume":"14","author":"Li","year":"2024","journal-title":"Sci Rep"},{"key":"2026090109063610600_bib42","doi-asserted-by":"crossref","first-page":"8896","DOI":"10.1158\/0008-5472.CAN-05-1734","article-title":"Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progression","volume":"65","author":"Queen","year":"2005","journal-title":"Cancer Res"},{"key":"2026090109063610600_bib43","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/ijc.30076","article-title":"Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer","volume":"139","author":"Galdiero","year":"2016","journal-title":"Int J Cancer"},{"key":"2026090109063610600_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199740","article-title":"Potential involvement of neutrophils in human thyroid cancer","volume":"13","author":"Galdiero","year":"2018","journal-title":"PLoS One"},{"key":"2026090109063610600_bib45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41419-020-03294-z","article-title":"A new risk factor indicator for papillary thyroid cancer based on immune infiltration","volume":"12","author":"Yang","year":"2021","journal-title":"Cell Death Dis"},{"key":"2026090109063610600_bib46","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1002\/hed.25740","article-title":"Tumor immune microenvironment characteristics of papillary thyroid carcinoma are associated with histopathological aggressiveness and BRAF mutation status","volume":"41","author":"Means","year":"2019","journal-title":"Head Neck"},{"key":"2026090109063610600_bib47","doi-asserted-by":"crossref","first-page":"10554","DOI":"10.3390\/ijms251910554","article-title":"Leader cells: invade and evade-the frontline of cancer progression","volume":"25","author":"Doran","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026090109063610600_bib48","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1038\/s41598-020-58534-1","article-title":"S100A12 is a promising biomarker in papillary thyroid cancer","volume":"10","author":"Wang","year":"2020","journal-title":"Sci Rep"},{"key":"2026090109063610600_bib49","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s12672-025-02550-y","article-title":"New therapeutic targets and mechanisms of papillary thyroid carcinoma identified by multi-omics analysis","volume":"16","author":"Xu","year":"2025","journal-title":"Discov Oncol"},{"key":"2026090109063610600_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2026.111251","article-title":"TNF-alpha: roles in pathogenesis and therapeutics in cancer","volume":"302","author":"Valenzuela-Cardenas","year":"2026","journal-title":"J Biol Chem"},{"key":"2026090109063610600_bib51","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1158\/1078-0432.CCR-18-3200","article-title":"Biological consequences of MHC-II expression by tumor cells in cancer","volume":"25","author":"Axelrod","year":"2019","journal-title":"Clin Cancer Res"},{"key":"2026090109063610600_bib52","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1046\/j.1365-2265.1996.00857.x","article-title":"HLA DRB1\/DQA1\/DQB1 haplotype determines thyroid autoimmunity in patients with insulin-dependent diabetes mellitus","volume":"45","author":"Chuang","year":"1996","journal-title":"Clin Endocrinol"},{"key":"2026090109063610600_bib53","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1210\/clinem\/dgaa656","article-title":"Inhibition of BRAF sensitizes thyroid carcinoma to immunotherapy by enhancing tsMHCII-mediated immune recognition","volume":"106","author":"Zhi","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"2026090109063610600_bib54","doi-asserted-by":"crossref","DOI":"10.1172\/JCI191781","article-title":"Loss of tumor cell MHC class II drives MAPK inhibitor insensitivity of BRAF-mutant anaplastic thyroid cancers","volume":"135","author":"Tiedje","year":"2025","journal-title":"J Clin Investig"},{"key":"2026090109063610600_bib55","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1172\/JCI98689","article-title":"Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma","volume":"128","author":"Veatch","year":"2018","journal-title":"J Clin Investig"},{"key":"2026090109063610600_bib56","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1158\/2326-6066.CIR-15-0243","article-title":"Expression of the MHC class II pathway in triple-negative breast cancer tumor cells is associated with a good prognosis and infiltrating lymphocytes","volume":"4","author":"Forero","year":"2016","journal-title":"Cancer Immunol Res"},{"key":"2026090109063610600_bib57","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1158\/0008-5472.CAN-22-0571","article-title":"Challenges of using IFNgamma in clinical settings","volume":"83","author":"Singh","year":"2023","journal-title":"Cancer Res"},{"key":"2026090109063610600_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.156046","article-title":"The paradoxical role of IFN-gamma in cancer: balancing immune activation and immune evasion","volume":"272","author":"Liu","year":"2025","journal-title":"Pathol Res Pract"},{"key":"2026090109063610600_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2023.101773","article-title":"Chemokines in thyroid autoimmunity","volume":"37","author":"Ferrari","year":"2023","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2026090109063610600_bib60","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2016.1168556","article-title":"The immune network in thyroid cancer","volume":"5","author":"Galdiero","year":"2016","journal-title":"Oncoimmunology"}],"container-title":["Endocrine-Related Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/doi\/10.1530\/ERC-26-0088\/523492\/erc-26-0088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/doi\/10.1530\/ERC-26-0088\/523492\/erc-26-0088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:06:51Z","timestamp":1788268011000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article\/33\/8\/e260088\/77987\/Myeloid-landscape-of-BRAF-mutant-papillary-thyroid"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,1]]},"references-count":58,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,1]]}},"URL":"https:\/\/doi.org\/10.1530\/erc-26-0088","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,1]]},"article-number":"e260088"}}