{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:51:42Z","timestamp":1791211902179,"version":"4.1.0"},"reference-count":0,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Subsequent thyroid carcinomas (STC) are common after childhood cancer treatment and have well-described risk factors, whereas information on subsequent thyroid adenomas (STA) remains limited. This study compared treatment-related risk factors for STC and STA, assessed their associations with the other subsequent neoplasms and evaluated the incidence of STC relative to the age-matched national general population. The study cohort included 4348 childhood cancer survivors treated between 1975 and 2020; 48% were female, 23% had lymphomas and 77% had solid tumors. STC occurred in 44 survivors (59% female) and STA in 23 (65% female). Compared with the national general population, the risk of STC was 7.6-fold higher in females and 23.6-fold higher in males. The median age at diagnosis was lower for STC (25.8 vs. 29.8 years). Hodgkin lymphoma was the most frequent primary cancer (48% vs. 57%). The median age at first cancer diagnosis was similar (9.8 vs. 9.4 years). Neck radiotherapy was a major risk factor in both groups (59% vs. 83%). Additional subsequent malignant neoplasms occurred in 14% of STC patients and 13% of STA patients, while subsequent benign neoplasms occurred in 20% and 26%, respectively. The incidence of subsequent benign neoplasms was higher in STC patients compared to other first subsequent malignant neoplasm patients (p&amp;lt;0.05). STC predominated over STA (66%). Shared risk factors included neck radiotherapy and Hodgkin lymphoma. STC was diagnosed at a younger age. The frequent occurrence of additional subsequent neoplasms highlights the need for long-term surveillance.<\/jats:p>","DOI":"10.1530\/erc-26-0210","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:53:35Z","timestamp":1791208415000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors for subsequent thyroid neoplasms development in childhood cancer survivors"],"prefix":"10.1530","author":[{"given":"Dana","family":"Nov\u00e1kov\u00e1","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and Endocrinology, 2nd Faculty of Medicine, Charles University and Motol and Homolka University Hospital 1 , ,","place":["Prague, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"\u0160vojgr","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and Motol and Homolka University Hospital 2 , ,","place":["Prague, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Katra","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat, 2nd Faculty of Medicine, Charles University and Motol and Homolka University Hospital 3 , ,","place":["Prague, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Bart\u016f\u0148kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and Motol and Homolka University Hospital 2 , ,","place":["Prague, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Vl\u010dek","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Endocrinology, 2nd Faculty of Medicine, Charles University and Motol and Homolka University Hospital 1 , ,","place":["Prague, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kindlov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Oncology, 2nd Faculty of Medicine, Charles University and Motol and Homolka University Hospital 4 , ,","place":["Prague, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Jirkovsk\u00e1","sequence":"additional","affiliation":[{"name":"Department of Oncology, 2nd Faculty of Medicine, Charles University and Motol and Homolka University Hospital 4 , ,","place":["Prague, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Blagod\u00e1rna","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and Motol and Homolka University Hospital 2 , ,","place":["Prague, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Eckschlager","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and Motol and Homolka University Hospital 2 , ,","place":["Prague, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"\u0160r\u00e1mkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and Motol and Homolka University Hospital 2 , ,","place":["Prague, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6576-7048","authenticated-orcid":true,"given":"Jarmila","family":"Kruseov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and Motol and Homolka University Hospital 2 , ,","place":["Prague, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,10,5]]},"container-title":["Endocrine-Related Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/doi\/10.1530\/ERC-26-0210\/526152\/erc-26-0210.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/doi\/10.1530\/ERC-26-0210\/526152\/erc-26-0210.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:53:36Z","timestamp":1791208416000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article\/doi\/10.1530\/ERC-26-0210\/78322\/Risk-factors-for-subsequent-thyroid-neoplasms"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1530\/erc-26-0210","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,5]]},"article-number":"ERC-26-0210"}}