{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:30Z","timestamp":1784557050851,"version":"3.55.0"},"reference-count":37,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["etj.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Medullary thyroid cancer (MTC) is a rare endocrine tumor, which can be sporadic or familial, as a component of multiple endocrine neoplasia 2 (MEN2). Overall, 10% of MTC cases have already developed at presentation or will develop metastasis during follow-up. Testicular metastases are exceptional and only one case of unilateral testis involvement by metastatic MTC has been already reported in literature. We described the first known case of asymptomatic bilateral testicular MTC metastases, discovered incidentally at testicular ultrasound (US) performed for unrelated reasons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A Latin American 32-year-old man with MEN 2A syndrome and metastatic MTC underwent andrological and urological examination due to premature ejaculation. US imaging showed two symmetrical hypoechoic lesions involving both testes. Suspecting a bilateral testicular cancer, the patient underwent excision biopsy of both testicular lesions. Histopathology and immunohistochemical examinations documented metastatic MTC of both testicular lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Beyond its rarity, testis should be considered as a potential metastatic site of MTC, especially in patients with advanced disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Established facts<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Distant metastases are present at the diagnosis in 10\u201315% of patients with medullary thyroid carcinoma (MTC).<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Testicular metastases are anecdotal. Only one case of unilateral testis involvement by metastatic MTC has been reported in the literature.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Novel insights<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Testis should be considered as a possible site of metastases in patients with diffuse metastatic MTC.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Testicular ultrasound could be considered as an useful tool for the evaluation and follow-up of metastatic MTC.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/etj-21-0016","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T06:44:03Z","timestamp":1645080243000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":1,"title":["Bilateral testicular metastases of medullary thyroid carcinoma in an adult male with multiple endocrine neoplasia 2A syndrome: case report and review of literature"],"prefix":"10.1530","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6933-2538","authenticated-orcid":true,"given":"Francesca","family":"Orsolini","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Prete","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierpaolo","family":"Falcetta","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Canale","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Basolo","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Al\u00ec","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Manassero","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Vitti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Elisei","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Molinaro","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"3149","article-title":"Multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma: an update","volume":"98","author":"Wells","year":"2013","unstructured":"Wells Jr SAPacini FRobinson BGSantoro M. Multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma: an update. Journal of Clinical Endocrinology and Metabolism2013983149\u20133164. (https:\/\/doi.org\/10.1210\/jc.2013-1204)"},{"key":"bib2","series-title":"Clinical Oncology","first-page":"475","article-title":"Medullary thyroid carcinoma","volume":"22","author":"Pacini","year":"2010","unstructured":"Pacini FCastagna MGCipri CSchlumberger M. Medullary thyroid carcinoma. Clinical Oncology201022475\u2013485. (https:\/\/doi.org\/10.1016\/j.clon.2010.05.002)"},{"key":"bib3","series-title":"Endocrinology and Metabolism Clinics of North America","first-page":"285","article-title":"Management of medullary thyroid cancer","volume":"48","author":"Viola","year":"2019","unstructured":"Viola DElisei R. Management of medullary thyroid cancer. Endocrinology and Metabolism Clinics of North America201948285\u2013301. (https:\/\/doi.org\/10.1016\/j.ecl.2018.11.006)"},{"key":"bib4","series-title":"Nature Reviews: Endocrinology","first-page":"192","article-title":"A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma","volume":"12","author":"Romei","year":"2016","unstructured":"Romei CCiampi RElisei R. A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma. Nature Reviews: Endocrinology201612192\u2013202. (https:\/\/doi.org\/10.1038\/nrendo.2016.11)"},{"key":"bib5","series-title":"Medicine","first-page":"319","article-title":"Medullary carcinoma of the thyroid. A study of the clinical features and prognostic factors in 161 patients","volume":"63","author":"Saad","year":"1984","unstructured":"Saad MFOrdonez NGRashid RKGuido JJHill Jr CSHickey RCSamaan NA. Medullary carcinoma of the thyroid. A study of the clinical features and prognostic factors in 161 patients. Medicine198463319\u2013342. (https:\/\/doi.org\/10.1097\/00005792-198411000-00001)"},{"key":"bib6","series-title":"European Thyroid Journal","first-page":"5","article-title":"2012 European Thyroid Association guidelines for metastatic medullary thyroid cancer","volume":"1","author":"Schlumberger","year":"2012","unstructured":"Schlumberger MBastholt LDralle HJarzab BPacini FSmit JWA & European Thyroid Association Task Force. 2012 European Thyroid Association guidelines for metastatic medullary thyroid cancer. European Thyroid Journal201215\u201314. (https:\/\/doi.org\/10.1159\/000336977)"},{"key":"bib7","series-title":"Cancer","first-page":"1139","article-title":"Medullary thyroid carcinoma: clinical characteristics, treatment, prognostic factors, and a comparison of staging systems","volume":"88","author":"Kebebew","year":"2000","unstructured":"Kebebew EItuarte PHSiperstein AEDuh QYClark OH. Medullary thyroid carcinoma: clinical characteristics, treatment, prognostic factors, and a comparison of staging systems. Cancer2000881139\u20131148. (https:\/\/doi.org\/10.1002\/(sici)1097-0142(20000301)88:5<1139::aid-cncr26>3.0.co;2-z)"},{"key":"bib8","series-title":"Journal of Neuro-Oncology","first-page":"63","article-title":"Pituitary metastasis from medullary carcinoma of thyroid: case report and review of literature","volume":"89","author":"Bhatoe","year":"2008","unstructured":"Bhatoe HSBadwal SDutta VKannan N. Pituitary metastasis from medullary carcinoma of thyroid: case report and review of literature. Journal of Neuro-Oncology20088963\u201367. (https:\/\/doi.org\/10.1007\/s11060-008-9586-5)"},{"key":"bib9","series-title":"Histopathology","first-page":"31","article-title":"Metastatic tumours in the testis","volume":"3","author":"Tiltman","year":"1979","unstructured":"Tiltman AJMetastatic tumours in the testis. Histopathology1979331\u201337. 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The adrenal metastasis of a medullary carcinoma of the thyroid. Revista Cl\u00ednica Espa\u00f1ola1995195847\u2013848."},{"key":"bib12","series-title":"European Heart Journal: Cardiovascular Imaging","first-page":"231","article-title":"Cardiac metastasis from medullary thyroid carcinoma: insights from multimodal molecular imaging and magnetic resonance imaging","volume":"21","author":"El Ghannudi","year":"2020","unstructured":"El Ghannudi SGermain PSchneegans OSchindler THImperiale A. Cardiac metastasis from medullary thyroid carcinoma: insights from multimodal molecular imaging and magnetic resonance imaging. European Heart Journal: Cardiovascular Imaging202021231\u2013232. (https:\/\/doi.org\/10.1093\/ehjci\/jez132)"},{"key":"bib13","series-title":"Endocrine Practice","first-page":"351","article-title":"Medullary thyroid carcinoma manifesting as an ovarian mass: case report and review of literature","volume":"14","author":"Gosnell","year":"2008","unstructured":"Gosnell JEMaa JClark OHDuh QY. Medullary thyroid carcinoma manifesting as an ovarian mass: case report and review of literature. Endocrine Practice200814351\u2013357. (https:\/\/doi.org\/10.4158\/EP.14.3.351)"},{"key":"bib14","series-title":"Endocrinology, Diabetes and Metabolism Case Reports","first-page":"21-0063","article-title":"Medullary thyroid carcinoma (MTC): unusual metastatic sites","volume":"2021","author":"Kazakou","year":"2021","unstructured":"Kazakou PSimeakis GAlevizaki MSaltiki K. Medullary thyroid carcinoma (MTC): unusual metastatic sites. Endocrinology, Diabetes and Metabolism Case Reports2021202121-0063. (https:\/\/doi.org\/10.1530\/EDM-21-0063)"},{"key":"bib15","series-title":"Thyroid","first-page":"831","article-title":"Metastatic breast involvement from medullary thyroid carcinoma: a clue to consider the need of early diagnosis and adequate surgical strategy","volume":"20","author":"Ricciato","year":"2010","unstructured":"Ricciato MPLombardi CPRaffaelli MDe Rosa ACorsello SM. Metastatic breast involvement from medullary thyroid carcinoma: a clue to consider the need of early diagnosis and adequate surgical strategy. Thyroid201020831\u2013832. (https:\/\/doi.org\/10.1089\/thy.2009.0191)"},{"key":"bib16","series-title":"BMC Endocrine Disorders","article-title":"Testicular and inguinal lymph node metastases of medullary thyroid cancer: a case report and review of the literature","volume":"14","author":"Appetecchia","year":"2014","unstructured":"Appetecchia MBarnabei APompeo VSentinelli SBaldelli RCorsello SMTorino F. Testicular and inguinal lymph node metastases of medullary thyroid cancer: a case report and review of the literature. BMC Endocrine Disorders201414 84. (https:\/\/doi.org\/10.1186\/1472-6823-14-84)"},{"key":"bib17","series-title":"European Journal of Endocrinology","first-page":"239","article-title":"Progression of medullary thyroid carcinoma: assessment with calcitonin and carcinoembryonic antigen doubling times","volume":"158","author":"Laure Giraudet","year":"2008","unstructured":"Laure Giraudet AAl Ghulzan AAup\u00e9rin ALeboulleux SChehboun ATroalen FDromain CLumbroso JBaudin ESchlumberger M. Progression of medullary thyroid carcinoma: assessment with calcitonin and carcinoembryonic antigen doubling times. European Journal of Endocrinology2008158239\u2013246. (https:\/\/doi.org\/10.1530\/EJE-07-0667)"},{"key":"bib18","series-title":"Journal of Urology","first-page":"272","article-title":"Diagnosis and treatment of early stage testicular cancer: AUA Guideline","volume":"202","author":"Stephenson","year":"2019","unstructured":"Stephenson AEggener SEBass EBChelnick DMDaneshmand SFeldman DGilligan TKaram JALeibovich BLiauw SLDiagnosis and treatment of early stage testicular cancer: AUA Guideline. Journal of Urology2019202272\u2013281. (https:\/\/doi.org\/10.1097\/JU.0000000000000318)"},{"key":"bib19","series-title":"Indian Journal of Cancer","first-page":"83","article-title":"Secondary carcinoma of testis \u2013 a clinicopathologic study of 10 cases","volume":"27","author":"Bhasin","year":"1990","unstructured":"Bhasin SDShrikhande SS. Secondary carcinoma of testis \u2013 a clinicopathologic study of 10 cases. Indian Journal of Cancer19902783\u201390."},{"key":"bib20","series-title":"Cancer","first-page":"481","article-title":"Secondary testicular tumors","volume":"30","author":"Pienkos","year":"1972","unstructured":"Pienkos EJJablokow VR. Secondary testicular tumors. Cancer197230481\u2013485. (https:\/\/doi.org\/10.1002\/1097-0142(197208)30:2<481::aid-cncr2820300228>3.0.co;2-x)"},{"key":"bib21","series-title":"Annals of Diagnostic Pathology","first-page":"59","article-title":"Testicular metastases from solid tumors: an autopsy study","volume":"4","author":"Garc\u00eda-Gonz\u00e1lez","year":"2000","unstructured":"Garc\u00eda-Gonz\u00e1lez RPinto JVal-Bernal JF. Testicular metastases from solid tumors: an autopsy study. Annals of Diagnostic Pathology2000459\u201364. (https:\/\/doi.org\/10.1016\/s1092-9134(0090012-1)"},{"key":"bib22","series-title":"Cancer","first-page":"709","article-title":"Metastatic carcinoma involving the testis. Clinical and pathologic distinction from primary testicular neoplasms","volume":"54","author":"Haupt","year":"1984","unstructured":"Haupt HMMann RBTrump DLAbeloff MD. Metastatic carcinoma involving the testis. Clinical and pathologic distinction from primary testicular neoplasms. Cancer198454709\u2013714. (https:\/\/doi.org\/10.1002\/1097-0142(1984)54:4<709::aid-cncr2820540419>3.0.co;2-6)"},{"key":"bib23","series-title":"Canadian Journal of Surgery","first-page":"359","article-title":"Metastatic tumours of the testes","volume":"29","author":"Grignon","year":"1986","unstructured":"Grignon DJShum DTHayman WP. Metastatic tumours of the testes. Canadian Journal of Surgery198629359\u2013361."},{"key":"bib24","series-title":"Journal of Urology","first-page":"489","article-title":"Secondary testicular tumors","volume":"118","author":"Cricco","year":"1977","unstructured":"Cricco RPKandzari SJ. Secondary testicular tumors. Journal of Urology1977118489\u2013490. (https:\/\/doi.org\/10.1016\/s0022-5347(1758077-5)"},{"key":"bib25","series-title":"Canadian Urological Association Journal","first-page":"E614","article-title":"Uncommon testicular metastasis of a primary neuroendocrine tumour of the lung","volume":"7","author":"Birker","year":"2013","unstructured":"Birker ILVan der Zee JAKeizer KM. Uncommon testicular metastasis of a primary neuroendocrine tumour of the lung. Canadian Urological Association Journal20137E614\u2013E617. (https:\/\/doi.org\/10.5489\/cuaj.398)"},{"key":"bib26","series-title":"Recent Results in Cancer Research","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/978-3-642-27994-2_20","article-title":"Rare metastases detected by (68)Ga-somatostatin receptor PET\/CT in patients with neuroendocrine tumors","volume":"194","author":"Carreras","year":"2013","unstructured":"Carreras CKulkarni HRBaum RP. Rare metastases detected by (68)Ga-somatostatin receptor PET\/CT in patients with neuroendocrine tumors. Recent Results in Cancer Research2013194379\u2013384. (https:\/\/doi.org\/10.1007\/978-3-642-27994-2_20)"},{"key":"bib27","series-title":"Clinical Nuclear Medicine","first-page":"e595","article-title":"Midgut NET With orbital, myocardial, testicular, lymph nodal and pulmonary metastases presenting with bilateral proptosis-role of 68Ga-DOTANOC PET\/CT","volume":"44","author":"Senthil","year":"2019","unstructured":"Senthil RPratap TVisakh RAPhilip M. Midgut NET With orbital, myocardial, testicular, lymph nodal and pulmonary metastases presenting with bilateral proptosis-role of 68Ga-DOTANOC PET\/CT. Clinical Nuclear Medicine201944e595\u2013e596. (https:\/\/doi.org\/10.1097\/RLU.0000000000002639)"},{"key":"bib28","series-title":"Journal of Clinical and Diagnostic Research","first-page":"TD03","article-title":"Bilateral testicular metastases from occult primary prostate cancer in a young adult: a rare case report","volume":"11","author":"Kamble","year":"2017","unstructured":"Kamble VRAgrawal PM. Bilateral testicular metastases from occult primary prostate cancer in a young adult: a rare case report. Journal of Clinical and Diagnostic Research201711TD03\u2013TD05. (https:\/\/doi.org\/10.7860\/JCDR\/2017\/25292.9783)"},{"key":"bib29","series-title":"Internal Medicine","first-page":"3277","article-title":"Bilateral testicular metastases from lung adenocarcinoma showing an objective response to Nivolumab: a case report and review of the literature","volume":"58","author":"Ozeki","year":"2019","unstructured":"Ozeki TFujiwara KShimonishi ANishimura JOkawa STakada KKayatani HMinami DSato KShibayama T. Bilateral testicular metastases from lung adenocarcinoma showing an objective response to Nivolumab: a case report and review of the literature. Internal Medicine2019583277\u20133282. (https:\/\/doi.org\/10.2169\/internalmedicine.2927-19)"},{"key":"bib30","series-title":"Oncology Letters","first-page":"1273","article-title":"Simultaneous bilateral testicular metastases from renal clear cell carcinoma: a case report and review of the literature","volume":"7","author":"Moriyama","year":"2014","unstructured":"Moriyama STakeshita HAdachi AArai YHiguchi STokairin TChiba KNakagawa KNoro A. Simultaneous bilateral testicular metastases from renal clear cell carcinoma: a case report and review of the literature. Oncology Letters201471273\u20131275. (https:\/\/doi.org\/10.3892\/ol.2014.1830)"},{"key":"bib31","series-title":"Urology","first-page":"601","article-title":"Metastatic carcinoma to testicle","volume":"17","author":"Askari","year":"1981","unstructured":"Askari AFaddoul AHerrera H. Metastatic carcinoma to testicle. Urology198117601\u2013603. (https:\/\/doi.org\/10.1016\/0090-4295(8190086-8)"},{"key":"bib32","series-title":"Translational Andrology and Urology","first-page":"434","article-title":"The pathophysiology of acquired premature ejaculation","volume":"5","author":"McMahon","year":"2016","unstructured":"McMahon CGJannini EASerefoglu ECHellstrom WJ. The pathophysiology of acquired premature ejaculation. Translational Andrology and Urology20165434\u2013449. (https:\/\/doi.org\/10.21037\/tau.2016.07.06)"},{"key":"bib33","series-title":"Nuclear Medicine and Molecular Imaging","first-page":"319","article-title":"Isolated testicular metastasis from prostate cancer detected on Ga-68 PSMA PET\/CT scan","volume":"54","author":"Gupta","year":"2020","unstructured":"Gupta NDey SVerma RBelho ES. Isolated testicular metastasis from prostate cancer detected on Ga-68 PSMA PET\/CT scan. Nuclear Medicine and Molecular Imaging202054319\u2013323. (https:\/\/doi.org\/10.1007\/s13139-020-00673-4)"},{"key":"bib34","series-title":"Journal of Urology","first-page":"653","article-title":"Metastatic carcinomas involving the testis: a review","volume":"109","author":"Meares","year":"1973","unstructured":"Meares EMHo TL. Metastatic carcinomas involving the testis: a review. Journal of Urology1973109653\u2013655. (https:\/\/doi.org\/10.1016\/s0022-5347(1760506-8)"},{"key":"bib35","series-title":"Clinical Nuclear Medicine","first-page":"86","article-title":"Asymptomatic solitary metastasis to the testis from prostate carcinoma detected by FDG PET\/CT","volume":"41","author":"Hsieh","year":"2016","unstructured":"Hsieh TCLin CCKao CHWu YCSun SS. Asymptomatic solitary metastasis to the testis from prostate carcinoma detected by FDG PET\/CT. Clinical Nuclear Medicine20164186\u201387. (https:\/\/doi.org\/10.1097\/RLU.0000000000001004)"},{"key":"bib36","series-title":"Cancer","first-page":"592","article-title":"Secondary carcinoma of the testis","volume":"10","author":"Price","year":"1957","unstructured":"Price EBMostofi FK. Secondary carcinoma of the testis. Cancer195710592\u2013595. (https:\/\/doi.org\/10.1002\/1097-0142(195705\/06)10:3<592::aid-cncr2820100326>3.0.co;2-3)"},{"key":"bib37","series-title":"Journal of Urology","first-page":"465","article-title":"Metastatic tumors to testicles: routes of metastasis","volume":"102","author":"Hanash","year":"1969","unstructured":"Hanash KACarney JAKelalis PP. Metastatic tumors to testicles: routes of metastasis. Journal of Urology1969102465\u2013468. 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