{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:01:44Z","timestamp":1790892104049,"version":"4.1.0"},"reference-count":37,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["etj.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Central sensitivity of thyroid hormone refers to the sensitivity of hypothalamic\u2013pituitary\u2013thyroid (HPT) axis to the change in circulating free thyroxine (fT4). A complex relationship exists between thyroxine levels and iodine nutritional status. To explore the relationship between thyroid hormone sensitivity and iodine nutritional status in elevated thyrotropin (TSH), we used national data to assess the relationship between thyroid hormone sensitivity and iodine nutritional status with contrasting demographic characteristics in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 12,197 participants with TSH &gt; 4.2 mIU\/L from China. Serum and urine samples were collected, and we measured serum fT4, TSH, thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) levels and urinary iodine concentration (UIC). The thyroid hormone sensitivity indices were calculated based on fT4 and TSH. The thyroid feedback quantile-based index (TFQI) is a new index to reflect thyroid hormone sensitivity. Higher TFQI quartiles indicated lower thyroid hormone sensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The odds ratios (ORs) for the fourth versus first TFQI quartile were 0.84 (95% CI 0.72\u20130.99) for iodine deficiency, 1.24 (95% CI 1.05\u20131.47) for TPOAb+, and 0.44 (95% CI 0.40\u20130.50) for females. The OR of the fourth and first TFQI quartiles for age &lt;30 years and &gt;60 years was 2.09 (95% CI 1.82\u20132.41) and 1.19 (95% CI 1.05\u20131.36), respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009 &lt; 0.05). Other thyroid sensitivity indices also yielded similar results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Thyroid hormone sensitivity and age have a U-shaped association in individuals with elevated TSH. Increased thyroid hormone sensitivity is associated with iodine deficiency and the female gender. Decreased thyroid hormone sensitivity is associated with TPOAb+. These findings are interesting and potentially useful for understanding the interaction between iodine nutrition and the hypothalamic\u2013pituitary\u2013thyroid axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/etj-21-0084","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T07:48:49Z","timestamp":1648194529000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":7,"title":["Iodine deficiency is associated with increased thyroid hormone sensitivity in individuals with elevated TSH"],"prefix":"10.1530","volume":"11","author":[{"given":"Ying","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China"},{"name":"Department of Endocrinology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China"},{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Heping District, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China"},{"name":"Department of Endocrinology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongze","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyan","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6445-6192","authenticated-orcid":true,"given":"Weiping","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Diabetes Care","first-page":"303","article-title":"Impaired sensitivity to thyroid hormones is associated with diabetes and metabolic syndrome","volume":"42","author":"Laclaustra","year":"2019","unstructured":"Laclaustra MMoreno-Franco BLou-Bonafonte JMMateo-Gallego RCasasnovas JAGuallar-Castillon PCenarro ACiveira F. Impaired sensitivity to thyroid hormones is associated with diabetes and metabolic syndrome. Diabetes Care201942303\u2013310. (https:\/\/doi.org\/10.2337\/dc18-1410)"},{"key":"bib2","series-title":"Endocrine Reviews","first-page":"556","article-title":"Thyroid hormone signaling and homeostasis during aging","volume":"34","author":"Bowers","year":"2013","unstructured":"Bowers JTerrien JClerget-Froidevaux MSGothi\u00e9 JDRozing MPWestendorp RGvan Heemst DDemeneix BA. Thyroid hormone signaling and homeostasis during aging. Endocrine Reviews201334556\u2013589. (https:\/\/doi.org\/10.1210\/er.2012-1056)"},{"key":"bib3","series-title":"New England Journal of Medicine","first-page":"2534","article-title":"Thyroid hormone therapy for older adults with subclinical hypothyroidism","volume":"376","author":"Stott","year":"2017","unstructured":"Stott DJRodondi NKearney PMFord IWestendorp RGJMooijaart SPSattar NAubert CEAujesky DBauer DCThyroid hormone therapy for older adults with subclinical hypothyroidism. New England Journal of Medicine20173762534\u20132544. (https:\/\/doi.org\/10.1056\/NEJMoa1603825)"},{"key":"bib4","series-title":"Thyroid","first-page":"1723","article-title":"Aging is associated with low thyroid state and organ-specific sensitivity to thyroxine","volume":"29","author":"Rakov","year":"2019","unstructured":"Rakov HDe Angelis MRenko KH\u00f6nes GSZwanziger DMoeller LCSchramm KWF\u00fchrer D. Aging is associated with low thyroid state and organ-specific sensitivity to thyroxine. Thyroid2019291723\u20131733. (https:\/\/doi.org\/10.1089\/thy.2018.0377)"},{"key":"bib5","series-title":"Lancet: Diabetes and Endocrinology","first-page":"286","article-title":"Iodine deficiency and thyroid disorders","volume":"3","author":"Zimmermann","year":"2015","unstructured":"Zimmermann MBBoelaert K. Iodine deficiency and thyroid disorders. Lancet: Diabetes and Endocrinology20153286\u2013295. (https:\/\/doi.org\/10.1016\/S2213-8587(1470225-6)"},{"key":"bib6","series-title":"New England Journal of Medicine","first-page":"2783","article-title":"Effect of iodine intake on thyroid diseases in China","volume":"354","author":"Teng","year":"2006","unstructured":"Teng WShan ZTeng XGuan HLi YTeng DJin YYu XFan CChong WEffect of iodine intake on thyroid diseases in China. New England Journal of Medicine20063542783\u20132793. (https:\/\/doi.org\/10.1056\/NEJMoa054022)"},{"key":"bib7","series-title":"Lancet","first-page":"1550","article-title":"Hypothyroidism","volume":"390","author":"Chaker","year":"2017","unstructured":"Chaker LBianco ACJonklaas JPeeters RP. Hypothyroidism. Lancet20173901550\u20131562. (https:\/\/doi.org\/10.1016\/S0140-6736(1730703-1)"},{"key":"bib8","series-title":"Thyroid","first-page":"1211","article-title":"Serum TSH and total T4 in the United States population and their association with participant characteristics: National Health and Nutrition Examination Survey (NHANES 1999\u20132002)","volume":"17","author":"Aoki","year":"2007","unstructured":"Aoki YBelin RMClickner RJeffries RPhillips LMahaffey KR. Serum TSH and total T4 in the United States population and their association with participant characteristics: National Health and Nutrition Examination Survey (NHANES 1999\u20132002). Thyroid2007171211\u20131223. (https:\/\/doi.org\/10.1089\/thy.2006.0235)"},{"key":"bib9","series-title":"Nature Reviews: Endocrinology","first-page":"301","article-title":"Global epidemiology of hyperthyroidism and hypothyroidism","volume":"14","author":"Taylor","year":"2018","unstructured":"Taylor PNAlbrecht DScholz AGutierrez-Buey GLazarus JHDayan CMOkosieme OE. Global epidemiology of hyperthyroidism and hypothyroidism. Nature Reviews: Endocrinology201814301\u2013316. (https:\/\/doi.org\/10.1038\/nrendo.2018.18)"},{"key":"bib10","series-title":"Journal of Clinical Investigation","first-page":"769","article-title":"Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine","volume":"125","author":"Werneck de Castro","year":"2015","unstructured":"Werneck de Castro JPFonseca TLUeta CBMcAninch EAAbdalla SWittmann GLechan RMGereben BBianco AC. Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. Journal of Clinical Investigation2015125769\u2013781. (https:\/\/doi.org\/10.1172\/JCI77588)"},{"key":"bib11","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"2299","article-title":"Quantitative assessment of pituitary resistance to thyroid hormone from plots of the logarithm of thyrotropin versus serum free thyroxine index","volume":"85","author":"Ercan-Fang","year":"2000","unstructured":"Ercan-Fang SSchwartz HLMariash CNOppenheimer JH. Quantitative assessment of pituitary resistance to thyroid hormone from plots of the logarithm of thyrotropin versus serum free thyroxine index. Journal of Clinical Endocrinology and Metabolism2000852299\u20132303. (https:\/\/doi.org\/10.1210\/jcem.85.6.6625)"},{"key":"bib12","series-title":"Thyroid","first-page":"568","article-title":"Efficacy and safety of long-term universal salt iodization on thyroid disorders: epidemiological evidence from 31 provinces of Mainland China","volume":"30","author":"Li","year":"2020","unstructured":"Li YTeng DBa JChen BDu JHe LLai XTeng XShi XLi YEfficacy and safety of long-term universal salt iodization on thyroid disorders: epidemiological evidence from 31 provinces of Mainland China. Thyroid202030568\u2013579. (https:\/\/doi.org\/10.1089\/thy.2019.0067)"},{"key":"bib13","series-title":"BMJ","article-title":"Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: National Cross Sectional Study","volume":"369","author":"Li","year":"2020","unstructured":"Li YTeng DShi XQin GQin YQuan HShi BSun HBa JChen BPrevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: National Cross Sectional Study. BMJ2020369 m997. (https:\/\/doi.org\/10.1136\/bmj.m997)"},{"key":"bib14","series-title":"Vital and Health Statistics, Series 1: Programs and Collection Procedures","first-page":"1","article-title":"National health and nutrition examination survey: plan and operations, 1999\u20132010","volume":"56","author":"Zipf","year":"2013","unstructured":"Zipf GChiappa MPorter KSOstchega YLewis BGDostal J. National health and nutrition examination survey: plan and operations, 1999\u20132010. Vital and Health Statistics, Series 1: Programs and Collection Procedures2013561\u201337."},{"key":"bib15","series-title":"Lancet","first-page":"1142","article-title":"Subclinical thyroid disease","volume":"379","author":"Cooper","year":"2012","unstructured":"Cooper DSBiondi B. Subclinical thyroid disease. Lancet20123791142\u20131154. (https:\/\/doi.org\/10.1016\/S0140-6736(1160276-6)"},{"key":"bib16","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"923","article-title":"The incidence and prevalence of thyroid dysfunction in Europe: a meta-analysis","volume":"99","author":"Garmendia Madariaga","year":"2014","unstructured":"Garmendia Madariaga ASantos Palacios SGuill\u00e9n-Grima FGalofr\u00e9 JC. The incidence and prevalence of thyroid dysfunction in Europe: a meta-analysis. Journal of Clinical Endocrinology and Metabolism201499923\u2013931. (https:\/\/doi.org\/10.1210\/jc.2013-2409)"},{"key":"bib17","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"1554","article-title":"Age-related changes in thyroid function: a longitudinal study of a community-based cohort","volume":"97","author":"Bremner","year":"2012","unstructured":"Bremner APFeddema PLeedman PJBrown SJBeilby JPLim EMWilson SGO\u2019Leary PCWalsh JP. Age-related changes in thyroid function: a longitudinal study of a community-based cohort. Journal of Clinical Endocrinology and Metabolism2012971554\u20131562. (https:\/\/doi.org\/10.1210\/jc.2011-3020)"},{"key":"bib18","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"3944","article-title":"Longitudinal changes in thyroid function in the oldest old and survival: the cardiovascular health study all-stars study","volume":"97","author":"Waring","year":"2012","unstructured":"Waring ACArnold AMNewman ABB\u00f9zkov\u00e1 PHirsch CCappola AR. Longitudinal changes in thyroid function in the oldest old and survival: the cardiovascular health study all-stars study. Journal of Clinical Endocrinology and Metabolism2012973944\u20133950. (https:\/\/doi.org\/10.1210\/jc.2012-2481)"},{"key":"bib19","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"4575","article-title":"Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism","volume":"92","author":"Surks","year":"2007","unstructured":"Surks MIHollowell JG. Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism. Journal of Clinical Endocrinology and Metabolism2007924575\u20134582. (https:\/\/doi.org\/10.1210\/jc.2007-1499)"},{"key":"bib20","series-title":"JAMA","first-page":"2591","article-title":"Thyroid status, disability and cognitive function, and survival in old age","volume":"292","author":"Gussekloo","year":"2004","unstructured":"Gussekloo Jvan Exel Ede Craen AJMeinders AEFr\u00f6lich MWestendorp RG. Thyroid status, disability and cognitive function, and survival in old age. JAMA20042922591\u20132599. (https:\/\/doi.org\/10.1001\/jama.292.21.2591)"},{"key":"bib21","series-title":"BMJ","article-title":"Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline","volume":"365","author":"Bekkering","year":"2019","unstructured":"Bekkering GEAgoritsas TLytvyn LHeen AFFeller MMoutzouri EAbdulazeem HAertgeerts BBeecher DBrito JPThyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline. BMJ2019365 l2006. (https:\/\/doi.org\/10.1136\/bmj.l2006)"},{"key":"bib22","series-title":"New England Journal of Medicine","article-title":"Thyroid hormone therapy for older adults with subclinical hypothyroidism","volume":"377","author":"Weickert","year":"2017","unstructured":"Weickert MOKyrou I. Thyroid hormone therapy for older adults with subclinical hypothyroidism. New England Journal of Medicine2017377 e20. (https:\/\/doi.org\/10.1056\/NEJMc1709989)"},{"key":"bib23","series-title":"JAMA","first-page":"1977","article-title":"Association between levothyroxine treatment and thyroid-related symptoms among adults aged 80 years and older with subclinical hypothyroidism","volume":"322","author":"Mooijaart","year":"2019","unstructured":"Mooijaart SPDu Puy RSStott DJKearney PMRodondi NWestendorp RGJden Elzen WPJPostmus IPoortvliet RKEvan Heemst DAssociation between levothyroxine treatment and thyroid-related symptoms among adults aged 80 years and older with subclinical hypothyroidism. JAMA20193221977\u20131986. (https:\/\/doi.org\/10.1001\/jama.2019.17274)"},{"key":"bib24","series-title":"Cochrane Database of Systematic Reviews","first-page":"CD011009","article-title":"Thyroxine replacement for subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism","volume":"6","author":"Akhtar","year":"2019","unstructured":"Akhtar MAAgrawal RBrown JSajjad YCraciunas L. Thyroxine replacement for subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism. Cochrane Database of Systematic Reviews20196CD011009. (https:\/\/doi.org\/10.1002\/14651858.CD011009.pub2)"},{"key":"bib25","series-title":"Endocrine Practice","first-page":"570","article-title":"Increased atherogenic low-density lipoprotein cholesterol in untreated subclinical hypothyroidism","volume":"14","author":"Mikhail","year":"2008","unstructured":"Mikhail GSAlshammari SMAlenezi MYMansour MKhalil NA. Increased atherogenic low-density lipoprotein cholesterol in untreated subclinical hypothyroidism. Endocrine Practice200814570\u2013575. (https:\/\/doi.org\/10.4158\/EP.14.5.570)"},{"key":"bib26","series-title":"Annals of Internal Medicine","first-page":"35","article-title":"Screening and treatment of thyroid dysfunction: an evidence review for the U.S. Preventive Services Task Force","volume":"162","author":"Rugge","year":"2015","unstructured":"Rugge JBBougatsos CChou R. Screening and treatment of thyroid dysfunction: an evidence review for the U.S. Preventive Services Task Force. Annals of Internal Medicine201516235\u201345. (https:\/\/doi.org\/10.7326\/M14-1456)"},{"key":"bib27","series-title":"European Journal of Endocrinology","first-page":"219","article-title":"The Danish investigation on iodine intake and thyroid disease, DanThyr: status and perspectives","volume":"155","author":"Laurberg","year":"2006","unstructured":"Laurberg PJ\u00f8rgensen TPerrild HOvesen LKnudsen NPedersen IBRasmussen LBCarl\u00e9 AVejbjerg P. The Danish investigation on iodine intake and thyroid disease, DanThyr: status and perspectives. European Journal of Endocrinology2006155219\u2013228. (https:\/\/doi.org\/10.1530\/eje.1.02210)"},{"key":"bib28","series-title":"Journal of Internal Medicine","first-page":"415","article-title":"High incidence of multinodular toxic goitre in the elderly population in a low iodine intake area vs. high incidence of Graves\u2019 disease in the young in a high iodine intake area: comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland","volume":"229","author":"Laurberg","year":"1991","unstructured":"Laurberg PPedersen KMVestergaard HSigurdsson G. High incidence of multinodular toxic goitre in the elderly population in a low iodine intake area vs. high incidence of Graves\u2019 disease in the young in a high iodine intake area: comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland. Journal of Internal Medicine1991229415\u2013420. (https:\/\/doi.org\/10.1111\/j.1365-2796.1991.tb00368.x)"},{"key":"bib29","series-title":"Endocrine Reviews","first-page":"504","article-title":"Molecular pathogenesis of euthyroid and toxic multinodular goiter","volume":"26","author":"Krohn","year":"2005","unstructured":"Krohn KF\u00fchrer DBayer YEszlinger MBrauer VNeumann SPaschke R. Molecular pathogenesis of euthyroid and toxic multinodular goiter. Endocrine Reviews200526504\u2013524. (https:\/\/doi.org\/10.1210\/er.2004-0005)"},{"key":"bib30","series-title":"Thyroid","first-page":"1125","article-title":"Iodine status and prevalence of thyroid disorders after introduction of mandatory universal salt iodization for 16 years in China: a cross-sectional study in 10 cities","volume":"26","author":"Shan","year":"2016","unstructured":"Shan ZChen LLian XLiu CShi BShi LTong NWang SWeng JZhao JIodine status and prevalence of thyroid disorders after introduction of mandatory universal salt iodization for 16 years in China: a cross-sectional study in 10 cities. Thyroid2016261125\u20131130. (https:\/\/doi.org\/10.1089\/thy.2015.0613)"},{"key":"bib31","series-title":"JAMA","first-page":"1563","article-title":"Variation in rates of autoimmune thyroid disease by race\/ethnicity in US military personnel","volume":"311","author":"McLeod","year":"2014","unstructured":"McLeod DSCaturegli PCooper DSMatos PGHutfless S. Variation in rates of autoimmune thyroid disease by race\/ethnicity in US military personnel. JAMA20143111563\u20131565. (https:\/\/doi.org\/10.1001\/jama.2013.285606)"},{"key":"bib32","series-title":"Clinical Endocrinology","first-page":"803","article-title":"Low prevalence of hypothyroidism among black and Mulatto people in a population-based study of Brazilian women","volume":"66","author":"Sichieri","year":"2007","unstructured":"Sichieri RBaima JMarante Tde Vasconcellos MTMoura ASVaisman M. Low prevalence of hypothyroidism among black and Mulatto people in a population-based study of Brazilian women. Clinical Endocrinology200766803\u2013807. (https:\/\/doi.org\/10.1111\/j.1365-2265.2007.02816.x)"},{"key":"bib33","series-title":"Archives of Internal Medicine","first-page":"1428","article-title":"Tobacco smoking and thyroid function: a population-based study","volume":"167","author":"Asvold","year":"2007","unstructured":"Asvold BOBj\u00f8ro TNilsen TIVatten LJ. Tobacco smoking and thyroid function: a population-based study. Archives of Internal Medicine20071671428\u20131432. (https:\/\/doi.org\/10.1001\/archinte.167.13.1428)"},{"key":"bib34","series-title":"Pharmacology and Therapeutics","first-page":"135","article-title":"New insights into thyroid hormone action","volume":"173","author":"Mendoza","year":"2017","unstructured":"Mendoza AHollenberg AN. New insights into thyroid hormone action. Pharmacology and Therapeutics2017173135\u2013145. (https:\/\/doi.org\/10.1016\/j.pharmthera.2017.02.012)"},{"key":"bib35","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"3389","article-title":"Psychological well-being correlates with free thyroxine but not free 3,5,3\u2032-triiodothyronine levels in patients on thyroid hormone replacement","volume":"91","author":"Saravanan","year":"2006","unstructured":"Saravanan PVisser TJDayan CM. Psychological well-being correlates with free thyroxine but not free 3,5,3\u2032-triiodothyronine levels in patients on thyroid hormone replacement. Journal of Clinical Endocrinology and Metabolism2006913389\u20133393. (https:\/\/doi.org\/10.1210\/jc.2006-0414)"},{"key":"bib36","series-title":"Journal of Clinical Investigation","first-page":"230","article-title":"Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain","volume":"129","author":"Jo","year":"2019","unstructured":"Jo SFonseca TLBocco BMLCFernandes GWMcAninch EABolin APDa Concei\u00e7\u00e3o RRWerneck-de-Castro JPIgnacio DLEgri PType 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain. Journal of Clinical Investigation2019129230\u2013245. (https:\/\/doi.org\/10.1172\/JCI123176)"},{"key":"bib37","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"2592","article-title":"Thyroxine-triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothyroidism: meta-analysis of randomized controlled trials","volume":"91","author":"Grozinsky-Glasberg","year":"2006","unstructured":"Grozinsky-Glasberg SFraser ANahshoni EWeizman ALeibovici L. Thyroxine-triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothyroidism: meta-analysis of randomized controlled trials. Journal of Clinical Endocrinology and Metabolism2006912592\u20132599. 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