{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:37Z","timestamp":1787022817886,"version":"build-2736575974"},"reference-count":20,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["etj.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the safety and long-term efficacy using the multiple overlapping ablation technique with a novel non-cooled microwave system in benign symptomatic thyroid nodules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort single-center study collected complication data from the start of the procedure to 30 days postoperatively and evaluated the safety and effectiveness with a follow-up of 24 months. Ultrasound examinations were performed to determine the volume shrinkage during follow-up. Thyroid function cosmetic and symptoms scores and satisfaction degree were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 30 symptomatic benign thyroid nodules were treated by microwave ablation using a power between 15 and 30 W depending on the size of the nodule to be treated. The volume reduction rates in months 1, 3, 6, 9, 12, and 24 after ablation were 32, 59, 67, 69, 73, and 81%, respectively. The mean symptom score and mean cosmetic score before treatment were 4 and 3, respectively, while after treatment they dropped to 3 and 1, respectively. Thyroid function indicators fluctuated in the normal range and those with hyperthyroidism recovered to normal parameters. One case of temporary laryngeal paralysis occurred postoperatively and fully recovered in less than 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The novel microwave ablation system presented herein can help achieve good clinical success rate in benign thyroid nodules with a satisfying safety profile. The microwave ablation performed with the multiple overlapping ablation technique could be a good alternative to surgery and radiofrequency ablation in the management of benign thyroid nodules.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/etj-22-0175","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T09:14:05Z","timestamp":1671786845000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":14,"title":["Multiple overlapping microwave ablation in benign thyroid nodule: a single-center 24-month study"],"prefix":"10.1530","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0214-3040","authenticated-orcid":true,"given":"Eduardo","family":"Crespo Vallejo","sequence":"first","affiliation":[{"name":"Interventional Radiology, Hospital Universitario Fundacion Jim\u00e9nez Diaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Hermosin","sequence":"additional","affiliation":[{"name":"Interventional Radiology, Hospital Universitario Fundacion Jim\u00e9nez Diaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Gargallo","sequence":"additional","affiliation":[{"name":"Endocrinology, Hospital Universitario Fundacion Jim\u00e9nez Diaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Villalba","sequence":"additional","affiliation":[{"name":"Interventional Radiology, Hospital Universitario Fundacion Jim\u00e9nez Diaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Daguer","sequence":"additional","affiliation":[{"name":"Interventional Radiology, Hospital Universitario Fundacion Jim\u00e9nez Diaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Flores","sequence":"additional","affiliation":[{"name":"Interventional Radiology, Hospital Universitario Fundacion Jim\u00e9nez Diaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Peria\u00f1ez","sequence":"additional","affiliation":[{"name":"Interventional Radiology, Hospital Universitario Fundacion Jim\u00e9nez Diaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Amor\u00edn","sequence":"additional","affiliation":[{"name":"Interventional Radiology, Hospital Universitario Fundacion Jim\u00e9nez Diaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Santos","sequence":"additional","affiliation":[{"name":"Interventional Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Endocrine Practice","first-page":"622","article-title":"American college of endocrinology, and associazione medici endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules - 2016 update appendix","volume":"22","author":"Gharib","year":"2016","unstructured":"Gharib HPapini EGarber JRDuick DSHarrell RMHeged\u00fcs LPaschke RValcavi RVitti PAACE\/ACE\/AME Task Force on Thyroid Nodules, American college of endocrinology, and associazione medici endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules - 2016 update appendix. Endocrine Practice201622622\u2013639. (https:\/\/doi.org\/10.4158\/EP161208.GL)"},{"key":"bib2","series-title":"European Thyroid Journal","first-page":"194","article-title":"European Thyroid Association survey on use of minimally invasive techniques for thyroid nodules","volume":"9","author":"Heged\u00fcs","year":"2020","unstructured":"Heged\u00fcs LFrasoldati ANegro RPapini E. European Thyroid Association survey on use of minimally invasive techniques for thyroid nodules. European Thyroid Journal20209194\u2013204. 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Advances in Clinical and Experimental Medicine2020291123\u20131129. (https:\/\/doi.org\/10.17219\/acem\/125433)"},{"key":"bib9","series-title":"Frontiers in Endocrinology (Lausanne)","article-title":"Microwave ablation compared with laser ablation for treating benign thyroid nodules in a propensity-score matching study","volume":"10","author":"Shi","year":"2019","unstructured":"Shi YFZhou PZhao YFLiu WGTian SMLiang YP. Microwave ablation compared with laser ablation for treating benign thyroid nodules in a propensity-score matching study. Frontiers in Endocrinology (Lausanne)201910 874. (https:\/\/doi.org\/10.3389\/fendo.2019.00874)"},{"key":"bib10","series-title":"Journal of Ultrasound","first-page":"11","article-title":"Image-guided thermal ablation of benign thyroid nodules","volume":"20","author":"Mainini","year":"2017","unstructured":"Mainini APMonaco CPescatori LCDe Angelis CSardanelli FSconfienza LMMauri G. Image-guided thermal ablation of benign thyroid nodules. 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(https:\/\/doi.org\/10.1097\/MNM.0000000000000242)"}],"container-title":["European Thyroid Journal"],"original-title":[],"link":[{"URL":"https:\/\/etj.bioscientifica.com\/view\/journals\/etj\/12\/1\/ETJ-22-0175.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/etj.bioscientifica.com\/downloadpdf\/journals\/etj\/12\/1\/ETJ-22-0175.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/etj.bioscientifica.com\/downloadpdf\/journals\/etj\/12\/1\/ETJ-22-0175.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:51:40Z","timestamp":1784555500000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/etj\/article\/2861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":20,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/etj-22-0175","relation":{},"ISSN":["2235-0802"],"issn-type":[{"value":"2235-0802","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,1]]}}}