{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:42:29Z","timestamp":1790653349232,"version":"4.1.0"},"reference-count":54,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["etj.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We investigated whether selenium supplementation improves quality-of-life (QoL) in patients with autoimmune thyroiditis (ID:NCT02013479).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 412 patients \u226518 years with serum thyroid peroxidase antibody (TPOAb) level \u2265100 IU\/mL in a multicentre double-blinded randomised clinical trial. The patients were allocated 1:1 to daily supplementation with either 200 \u03bcg selenium as selenium-enriched yeast or matching placebo tablets for 12 months, as add-on to levothyroxine (LT4) treatment. QoL, assessed by the Thyroid-related Patient-Reported-Outcome questionnaire (ThyPRO-39), was measured at baseline, after 6 weeks, and after 3, 6, 12, and 18 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 332 patients (81%) completed the intervention period, of whom 82% were women. Although QoL improved during the trial, no difference in any of the ThyPRO-39 scales was found between the selenium group and the placebo group after 12 months of intervention. In addition, employing linear mixed model regression no difference between the two groups was observed in the ThyPRO-39 composite score (28.8 (95% CI: 24.5\u201333.6) and 28.0 (24.5\u201333.1), respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.602). Stratifying the patients according to duration of the disease at inclusion, ThyPRO-39 composite score, TPOAb level, or selenium status at baseline did not significantly change the results. TPOAb levels after 12 months of intervention were lower in the selenium group than in the placebo group (1995 (95% CI: 1512\u20132512) vs 2344 kIU\/L (1862\u20132951);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.016) but did not influence LT4 dosage or free triiodothyronine\u2013free thyroxine ratio.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In hypothyroid patients on LT4 therapy due to autoimmune thyroiditis, daily supplementation with 200 \u03bcg selenium or placebo for 12 months improved QoL to the same extent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/etj-23-0175","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T15:07:47Z","timestamp":1705072067000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":15,"title":["Selenium supplementation and placebo are equally effective in improving quality of life in patients with hypothyroidism"],"prefix":"10.1530","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7342-8660","authenticated-orcid":true,"given":"Camilla","family":"B\u00f8gelund Larsen","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Odense University Hospital, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian Hillert","family":"Winther","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Karkov","family":"Cramon","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9729-4767","authenticated-orcid":true,"given":"\u00c5se Krogh","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Feldt-Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health and Clinical Sciences, Copenhagen University, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils Jakob","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Bispebjerg University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob Bue","family":"Bjorner","sequence":"additional","affiliation":[{"name":"Department of Public Health, Copenhagen University, Copenhagen, Denmark"},{"name":"QualityMetric Inc, Johnston, Lincoln, Rhode Island, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Schomburg","sequence":"additional","affiliation":[{"name":"Institute for Experimental Endocrinology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Demircan","sequence":"additional","affiliation":[{"name":"Institute for Experimental Endocrinology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo Samson","family":"Chillon","sequence":"additional","affiliation":[{"name":"Institute for Experimental Endocrinology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeppe","family":"Gram","sequence":"additional","affiliation":[{"name":"Medical Department, Endocrinology, University Hospital of South-West Jutland, Esbjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stinus Gadegaard","family":"Hansen","sequence":"additional","affiliation":[{"name":"Medical Department, Endocrinology, University Hospital of South-West Jutland, Esbjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"Internal Medicine Research Unit, University Hospital of Southern Jutland, Aabenraa, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte","family":"Nygaard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torquil","family":"Watt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health and Clinical Sciences, Copenhagen University, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Heged\u00fcs","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Odense University Hospital, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen Joop","family":"Bonnema","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Odense University Hospital, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Nature Reviews Endocrinology","first-page":"301","article-title":"Global epidemiology of 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