{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:37Z","timestamp":1784557057738,"version":"3.55.0"},"reference-count":57,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["etj.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4,29]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Maternal thyroid autoimmunity and thyroid function in early pregnancy may impact fetal neurodevelopment. We aimed to investigate how thyroid autoimmunity and thyroid function in early pregnancy were associated with language acquisition in offspring at 12\u201336 months of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was embedded in the prospective Odense child cohort. Mother\u2013child dyads were excluded in case of maternal intake of thyroid medication during pregnancy. The parents completed MacArthur\u2013Bates Communicative Development Inventories (MB-CDI) every third month to assess their offspring\u2019s productive vocabulary. All completed reports for each child were included in the analyses. Logistic growth curve models evaluated associations between MB-CDI scores and levels of maternal thyroid peroxidase antibodies (TPOAb), free thyroxine (FT4), and thyrotropin, respectively, measured in early pregnancy (median gestational week 12). All models were stratified by offspring sex and adjusted for maternal age, education, pre-pregnancy body mass index, parity, breastfeeding, and offspring age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 735 mother\u2013child dyads. Children born to mothers with TPOAb \u226511 kIU\/L, opposed to TPOAb &lt;11 kIU\/L, had a lower probability of producing words at age 18\u201336 months for girls (OR\u2009=\u20090.78,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) and 33\u201336 months for boys (OR\u2009=\u20090.83,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). The probability of producing words was higher in girls at 30\u201336 months of age with low-normal maternal FT4 vs high-normal FT4 (OR\u2009=\u20090.60,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), and a similar trend was seen in boys. Results were ambiguous for thyrotropin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In women without known thyroid disease, TPOAb positivity in early pregnancy was negatively associated with productive vocabulary acquisition in girls and boys. This association was not mediated by a decreased thyroid function, as low-normal maternal FT4, unexpectedly, indicated better vocabulary acquisition. Our results support that maternal thyroid autoimmunity\n                      <jats:italic>per se<\/jats:italic>\n                      may affect fetal neurodevelopment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/etj-23-0233","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T14:20:21Z","timestamp":1714400421000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":3,"title":["Thyroid autoimmunity in euthyroid pregnant women is associated with slower productive language acquisition: the Odense child cohort study"],"prefix":"10.1530","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2679-7153","authenticated-orcid":true,"given":"Kamilla R","family":"Riis","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark"},{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6898-1752","authenticated-orcid":true,"given":"Steen J","family":"Bonnema","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark"},{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8079-213X","authenticated-orcid":true,"given":"Anja F","family":"Dreyer","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark"},{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-8025","authenticated-orcid":true,"given":"Dorte","family":"Glintborg","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5838-556X","authenticated-orcid":true,"given":"Niels","family":"Bilenberg","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Mental Health, Mental Health Services in the Region of Southern Denmark, University of Southern Denmark Odense, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1670-4742","authenticated-orcid":true,"given":"Dorthe","family":"Bleses","sequence":"additional","affiliation":[{"name":"TrygFonden\u2019s Centre for Child Research and School of Communication and Culture, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5900-7616","authenticated-orcid":true,"given":"Fabio","family":"Trecca","sequence":"additional","affiliation":[{"name":"TrygFonden\u2019s Centre for Child Research and School of Communication and Culture, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4603-9504","authenticated-orcid":true,"given":"Marianne S","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark"},{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Best Practice and Research","first-page":"599","article-title":"Early determinants of mental health","volume":"26","author":"R\u00e4ikk\u00f6nen","year":"2012","unstructured":"R\u00e4ikk\u00f6nen KPesonen AKRoseboom TJ & Eriksson JG. 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