{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:54:18Z","timestamp":1786787658476,"version":"build-2736575974"},"reference-count":17,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["etj.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2,6]]},"abstract":"<jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                    <jats:p>\n                      <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"images\/ETJ-23-0244inf1.jpeg\"\/>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      In 2022, the European Chemicals Agency (ECHA) made a statement concluding that iodine is an endocrine disruptor (ED). We stress the fact that the ECHA opinion ECHA\/BPC\/357\/2022 is based on their misguidedly zooming in on exclusively the biocidal products (e.g. hand disinfectants, disinfection of animals\u2019 teats\/udder, embalming fluids before cremation) that contain molecular iodine (I\n                      <jats:sub>2<\/jats:sub>\n                      ), entirely neglecting the 2013 ECHA Regulation (EU) no. 528\/2012 describing iodine as being of \u2018great importance for human health\u2019. Clearly, the current sweeping and erroneous classification of \u2018iodine\u2019 as an endocrine disruptor is ill-advised. We moreover call upon the scientific and medical community at large to use the accurate scientific nomenclature, i.e. iodide or iodate instead of \u2018iodine\u2019 when referring to iodized salts and food prepared there with. Drugs, diagnostic agents, and synthetic chemicals containing the element iodine in the form of covalent bonds must be correctly labeled \u2018iodinated\u2019, if possible, using each time their distinctive and accurate chemical or pharmacological name.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/etj-23-0244","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T09:48:50Z","timestamp":1707212930000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":5,"title":["The ETA\u2013ESE statement on the European Chemicals Agency opinion on iodine as an endocrine disruptor"],"prefix":"10.1530","volume":"13","author":[{"given":"Rodrigo","family":"Moreno-Reyes","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Hospital Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Feldt-Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, University Hospital Rigshospitalet, and Faculty of \u0397ealth and Clinical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Piekie\u0142ko-Witkowska","sequence":"additional","affiliation":[{"name":"Centre of Postgraduate Medical Education, Centre of Translational Research, Department of Biochemistry and Molecular Biology, Warsaw, Poland: Basic Lead of the European Society of Endocrinology Focus Area on Thyroid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-9130","authenticated-orcid":true,"given":"Adriana","family":"Gaspar da Rocha","sequence":"additional","affiliation":[{"name":"Public Health Unit, ULS Baixo Mondego, Figueira da Foz, Portugal Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corin","family":"Badiu","sequence":"additional","affiliation":[{"name":"National Institute of Endocrinology \"C. Davila\" University of Medicine and Pharmacy, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"K\u00f6hrle","sequence":"additional","affiliation":[{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Institut f\u00fcr Experimentelle Endokrinologie, Berlin, Germany: Co-Lead of the European Society of Endocrinology Focus Area on Environmental Endocrinology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9133-4089","authenticated-orcid":true,"given":"Leonidas","family":"Duntas","sequence":"additional","affiliation":[{"name":"Evgenideion Hospital, Unit of Endocrinology, Metabolism and Diabetes, National Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","article-title":"10.1 Draft BPC opinion on the review of approval of the active substance iodine and polyvinylpyrrolidone iodine","unstructured":"44th meeting of the Biocidal Products Committee (BPC). 10.1 Draft BPC opinion on the review of approval of the active substance iodine and polyvinylpyrrolidone iodinep. BPC-44-2022-20A, B, C. Available at: https:\/\/echa.europa.eu\/documents\/10162\/2199650\/bpc-a-44-2022_draft_agenda_en.pdf\/8824aef4-6ecf-db886416d46a6d5?t=1663320252339"},{"key":"bib2","article-title":"Eval","year":"2013","unstructured":"ECHA, 2013 Regulation (EU) n\u00b0528\/2012 concerning the making available on the market and use of biocidal products. Evaluation of active substances Assessment Report. Iodine (including PVP-iodine). Sweden2013."},{"key":"bib3","series-title":"Thyroid","first-page":"143","article-title":"The prevention of iodine deficiency: a history","volume":"33","author":"Pearce","year":"2023","unstructured":"Pearce EN & Zimmermann MB. The prevention of iodine deficiency: a history. Thyroid202333143\u2013149. (https:\/\/doi.org\/10.1089\/thy.2022.0454)"},{"key":"bib4","article-title":"Povidone-Iodine In: Drugs and lact","year":"2006","unstructured":"Povidone-Iodine In: Drugs and lactation database (LactMed\u00ae) [Internet]. Bethesda (MD National Institute of Child Health and Human Development, Bethesda, MD, USA)2006."},{"key":"bib5","series-title":"Archives of Disease in Childhood","first-page":"1297","article-title":"Withdrawal of iodinated disinfectants at delivery decreases the recall rate at neonatal screening for congenital hypothyroidism","volume":"63","author":"Chanoine","year":"1988","unstructured":"Chanoine JPPardou ABourdoux P & Delange F. Withdrawal of iodinated disinfectants at delivery decreases the recall rate at neonatal screening for congenital hypothyroidism. Archives of Disease in Childhood1988631297\u20131298. (https:\/\/doi.org\/10.1136\/adc.63.10.1297-b)"},{"key":"bib6","series-title":"Comprehensive Handbook of Iodine Nutritional, Biochemical, Pathological and Therapeutic Aspects","first-page":"139","article-title":"Chapter 15: iodine speciat","author":"Hou","year":"2009","unstructured":"Hou X. Chapter 15: iodine speciation in foodstuffs, tissues, and environmental samples: iodine species and analytical method. In Comprehensive Handbook of Iodine Nutritional, Biochemical, Pathological and Therapeutic Aspects, pp. 139\u20131502009. Elsevier: Cambridge, MA, USA."},{"key":"bib7","series-title":"Comprehensive Handbook of Iodine Nutritional, Biochemical, Pathological and Therapeutic Aspects","first-page":"909","article-title":"Chapter 94: the","author":"B\u00fcrgi","year":"2009","unstructured":"B\u00fcrgi HSchaffner Th & Seiler JP. Chapter 94: the toxicology of iodate: a literature survey in view of its use in iodized salt. In Comprehensive Handbook of Iodine Nutritional, Biochemical, Pathological and Therapeutic Aspects, pp. 909\u20139182009. Elsevier: Cambridge, MA, USA."},{"key":"bib8","series-title":"Nutrients","first-page":"3474","article-title":"Iodine, and iodine deficiency: a comprehensive review of a re-emerging issue","volume":"14","author":"Hatch-McChesney","year":"2022","unstructured":"Hatch-McChesney A & Lieberman HR. Iodine, and iodine deficiency: a comprehensive review of a re-emerging issue. Nutrients2022143474. (https:\/\/doi.org\/10.3390\/nu14173474)"},{"key":"bib9","series-title":"Indian Journal of Endocrinology and Metabolism","first-page":"534","article-title":"Reluctance in use of iodized salt for elimination of iodine deficiency","volume":"19","author":"Elahi","year":"2015","unstructured":"Elahi SSyed ZSaleem N & Rizvi NB. Reluctance in use of iodized salt for elimination of iodine deficiency. Indian Journal of Endocrinology and Metabolism201519534\u2013535. (https:\/\/doi.org\/10.4103\/2230-8210.159069)"},{"key":"bib10","unstructured":"Available at: https:\/\/www.theguardian.com\/world\/2013\/jan\/15\/iodised-salt-pakistan-health-crisis"},{"key":"bib11","series-title":"Schweizerische Medizinische Wochenschrift","first-page":"245","article-title":"The prevention of goiter and goiter recurrence","volume":"53","author":"Eggenberger","year":"1923","unstructured":"Eggenberger H. The prevention of goiter and goiter recurrence [in German]. Schweizerische Medizinische Wochenschrift192353245\u2013249."},{"key":"bib12","series-title":"Endocrine Reviews","first-page":"376","article-title":"Iodine deficiency","volume":"30","author":"Zimmermann","year":"2009","unstructured":"Zimmermann MB. Iodine deficiency. Endocrine Reviews200930376\u2013408. (https:\/\/doi.org\/10.1210\/er.2009-0011)"},{"key":"bib13","series-title":"Lancet Diabetes and Endocrinology","first-page":"286","article-title":"Iodine deficiency and thyroid disorders","volume":"3","author":"Zimmermann","year":"2015","unstructured":"Zimmermann MB & Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes and Endocrinology20153286\u2013295. (https:\/\/doi.org\/10.1016\/S2213-8587(1470225-6)"},{"key":"bib14","series-title":"European Thyroid Journal","first-page":"269","article-title":"2021 European Thyroid Association guidelines for the management of iodine-based contrast media-induced thyroid dysfunction","volume":"10","author":"Bednarczuk","year":"2021","unstructured":"Bednarczuk TBrix THSchima WZettinig G & Kahaly GJ. 2021 European Thyroid Association guidelines for the management of iodine-based contrast media-induced thyroid dysfunction. European Thyroid Journal202110269\u2013284. (https:\/\/doi.org\/10.1159\/000517175)"},{"key":"bib15","series-title":"Frontiers in Endocrinology","first-page":"1049423","article-title":"The relationship between urinary iodine concentration and papillary thyroid cancer: a systematic review and meta-analysis","volume":"13","author":"Zhang","year":"2022","unstructured":"Zhang XZhang FLi QAihaiti RFeng CChen DZhao X & Teng W. The relationship between urinary iodine concentration and papillary thyroid cancer: a systematic review and meta-analysis. Frontiers in Endocrinology2022131049423. (https:\/\/doi.org\/10.3389\/fendo.2022.1049423)"},{"key":"bib16","series-title":"Thyroid","first-page":"1802","article-title":"Estimating the health and economic benefits of universal salt Iodization programs to correct iodine deficiency disorders","volume":"30","author":"Gorstein","year":"2020","unstructured":"Gorstein JLBagriansky JPearce ENKupka R & Zimmermann MB. Estimating the health and economic benefits of universal salt Iodization programs to correct iodine deficiency disorders. Thyroid2020301802\u20131809. (https:\/\/doi.org\/10.1089\/thy.2019.0719)"},{"key":"bib17","series-title":"Proceedings of the Nutrition Society","first-page":"113","article-title":"The rem","volume":"82","author":"Zimmermann","year":"2023","unstructured":"Zimmermann MB. The remarkable impact of iodisation programmes on global public health. Proceedings of the Nutrition Society202382113\u2013119. (https:\/\/doi.org\/10.1017\/S0029665122002762)"}],"container-title":["European Thyroid Journal"],"original-title":[],"link":[{"URL":"https:\/\/etj.bioscientifica.com\/view\/journals\/etj\/13\/1\/ETJ-23-0244.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/etj.bioscientifica.com\/downloadpdf\/journals\/etj\/13\/1\/ETJ-23-0244.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/etj.bioscientifica.com\/downloadpdf\/journals\/etj\/13\/1\/ETJ-23-0244.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:51:56Z","timestamp":1784555516000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/etj\/article\/2966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,6]]},"references-count":17,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/etj-23-0244","relation":{},"ISSN":["2235-0802"],"issn-type":[{"value":"2235-0802","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,6]]}}}