{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:39Z","timestamp":1784557059877,"version":"3.55.0"},"reference-count":52,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["etj.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,30]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Treatment of patients with pediatric differentiated thyroid cancer (DTC) often involves radioiodine (RAI), which is associated with increased risks of short- and long-term adverse outcomes. The impact of RAI treatment on the female reproductive system remains uncertain. Anti-M\u00fcllerian hormone (AMH) is a marker of ovarian reserve and is related to fertility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim was to analyze the association between RAI and serum AMH level in women treated with RAI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated women with pediatric DTC treated with RAI at the age of \u226419 years. Serum AMH was measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 47 patients with a mean age of 25.1 years (12.4\u201350.8) at AMH measurement and follow-up of 11.8 \u00b1 8.4 years. The mean RAI administered was 235 mCi (30\u20131150). Sixteen (34%) received multiple RAI doses (471 \u00b1 215 mCi). Mean AMH level was 2.49 ng\/mL (0.01\u20137.81); the level was 1.57 ng\/mL (0.01\u20137.81) after multiple RAI doses and 2.99 ng\/mL (0.01\u20136.63) after a single RAI dose (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01). Patients who received a cumulative RAI lower than 200 mCi had higher AMH levels (2.23 ng\/mL, 0.39\u20137.81) than those who received more (1.0 ng\/mL, 0.01\u20136.63;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02). In patients with similar cumulative RAI activities, administration of multiple RAI doses was significantly and independently associated with AMH level lower than the reference range for age (HR: 5.9, 1.55\u201352.2,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014) after age adjustments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Levels of AMH were lower after multiple RAI doses, especially after a cumulative RAI dose above 200 mCi. More studies are needed to clarify the impact of RAI on fertility considering its cumulative activity and treatment strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/etj-23-0252","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T13:10:48Z","timestamp":1706620248000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":5,"title":["Serum anti-M\u00fcllerian hormone is lower in patients with multiple radioiodine dose for treatment of pediatric thyroid cancer"],"prefix":"10.1530","volume":"13","author":[{"given":"Marise Codeco de Andrade","family":"Barreto","sequence":"first","affiliation":[{"name":"Department of Oncologic Endocrinology, Instituto Nacional de C\u00e2ncer \u2013 INCA, Rio de Janeiro, RJ, Brazil"},{"name":"Department of Endocrinology, Universidade Federal do Rio de Janeiro \u2013 UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Treistman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Universidade Federal do Rio de Janeiro \u2013 UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Bessa Campelo Pinheiro","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Universidade Federal do Rio de Janeiro \u2013 UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bulzico","sequence":"additional","affiliation":[{"name":"Department of Oncologic Endocrinology, Instituto Nacional de C\u00e2ncer \u2013 INCA, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Accioly","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Oncologic Endocrinology, Instituto Nacional de C\u00e2ncer \u2013 INCA, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana","family":"Corbo","sequence":"additional","affiliation":[{"name":"Department of Oncologic Endocrinology, Instituto Nacional de C\u00e2ncer \u2013 INCA, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Alonso Garcia","family":"Alves Junior","sequence":"additional","affiliation":[{"name":"Department of Oncologic Endocrinology, Instituto Nacional de C\u00e2ncer \u2013 INCA, Rio de Janeiro, RJ, Brazil"},{"name":"Department of Endocrinology, Universidade Federal do Rio de Janeiro \u2013 UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6835-7108","authenticated-orcid":true,"given":"Fernanda","family":"Vaisman","sequence":"additional","affiliation":[{"name":"Department of Oncologic Endocrinology, Instituto Nacional de C\u00e2ncer \u2013 INCA, Rio de Janeiro, RJ, Brazil"},{"name":"Department of Endocrinology, Universidade Federal do Rio de Janeiro \u2013 UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Cancers","first-page":"2382","article-title":"Risk of adverse pregnancy outcomes in young women with thyroid cancer: a systematic review and meta-analysis","volume":"14","author":"Moon","year":"2022","unstructured":"Moon SYi KH & Park YJ. Risk of adverse pregnancy outcomes in young women with thyroid cancer: a systematic review and meta-analysis. Cancers2022142382. (https:\/\/doi.org\/10.3390\/cancers14102382)"},{"key":"bib2","series-title":"Scientific Reports","first-page":"3704","article-title":"Radioactive iodine and female fertility","volume":"12","author":"Navarro","year":"2022","unstructured":"Navarro PRocher SMir\u00f3-Mart\u00ednez P & Oltra-Crespo S. Radioactive iodine and female fertility. Scientific Reports2022123704. (https:\/\/doi.org\/10.1038\/s41598-022-07592-8)"},{"key":"bib3","series-title":"Endocrine Connections","first-page":"1283","article-title":"Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine","volume":"10","author":"Adamska","year":"2021","unstructured":"Adamska ATomczuk-Bobik PPop\u0142awska-Kita ABSiewko KBuczy\u0144ska ASzumowski P\u017bukowski \u0141My\u015bliwiec JZbucka-Kr\u0119towska MAdamski M, et al.Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine. Endocrine Connections2021101283\u20131290. (https:\/\/doi.org\/10.1530\/EC-21-0187)"},{"key":"bib4","series-title":"International Journal of Cancer","first-page":"2291","article-title":"Birth rates after radioactive iodine treatment for differentiated thyroid cancer","volume":"141","author":"Anderson","year":"2017","unstructured":"Anderson CEngel SMWeaver MAZevallos JP & Nichols HB. Birth rates after radioactive iodine treatment for differentiated thyroid cancer. International Journal of Cancer20171412291\u20132295. (https:\/\/doi.org\/10.1002\/ijc.30917)"},{"key":"bib5","series-title":"Clinical Endocrinology","first-page":"479","article-title":"A systematic review examining the effects of therapeutic radioactive iodine on ovarian function and future pregnancy in female thyroid cancer survivors","volume":"69","author":"Sawka","year":"2008","unstructured":"Sawka AMLakra DCLea JAlshehri BTsang RWBrierley JDStraus SThabane LGafni AEzzat S, et al.A systematic review examining the effects of therapeutic radioactive iodine on ovarian function and future pregnancy in female thyroid cancer survivors. Clinical Endocrinology200869479\u2013490. (https:\/\/doi.org\/10.1111\/j.1365-2265.2008.03222.x)"},{"key":"bib6","series-title":"Postgraduate Medical Journal","first-page":"92","article-title":"Prognosis for fertility and ovarian function after treatment with radioiodine for thyroid cancer","volume":"78","author":"Vini","year":"2002","unstructured":"Vini LHyer SAl-Saadi APratt B & Harmer C. Prognosis for fertility and ovarian function after treatment with radioiodine for thyroid cancer. Postgraduate Medical Journal20027892\u201393. (https:\/\/doi.org\/10.1136\/pmj.78.916.92)"},{"key":"bib7","series-title":"Pediatric Blood and Cancer","article-title":"Early and late adverse effects of radioiodine for pediatric differentiated thyroid cancer","volume":"64","author":"Albano","year":"2017","unstructured":"Albano DBertagna FPanarotto MB & Giubbini R. Early and late adverse effects of radioiodine for pediatric differentiated thyroid cancer. Pediatric Blood and Cancer201764. 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Journal of Nuclear Medicine199738669\u2013675."},{"key":"bib10","series-title":"Thyroid","first-page":"1169","article-title":"Long-term effects of radioiodine treatment on female fertility in survivors of childhood differentiated thyroid carcinoma","volume":"30","author":"Nies","year":"2020","unstructured":"Nies MCantineau AEPArts EGJMvan den Berg MHvan Leeuwen FEMuller Kobold ACKlein Hesselink MSBurgerhof JGMBrouwers AHvan Dam EWCM, et al.Long-term effects of radioiodine treatment on female fertility in survivors of childhood differentiated thyroid carcinoma. Thyroid2020301169\u20131176. (https:\/\/doi.org\/10.1089\/thy.2019.0560)"},{"key":"bib11","series-title":"International Journal of Endocrinology","first-page":"7586482","article-title":"Long-term quality of life and pregnancy outcomes of differentiated thyroid cancer survivors treated by total thyroidectomy and I(131) during adolescence and young adulthood","volume":"2016","author":"Metallo","year":"2016","unstructured":"Metallo MGroza LBrunaud LKlein MWeryha G & Feigerlova E. Long-term quality of life and pregnancy outcomes of differentiated thyroid cancer survivors treated by total thyroidectomy and I(131) during adolescence and young adulthood. International Journal of Endocrinology201620167586482. (https:\/\/doi.org\/10.1155\/2016\/7586482)"},{"key":"bib12","series-title":"Molecular and Cellular Endocrinology","first-page":"43","article-title":"Follicle dynamics during ovarian ageing","volume":"163","author":"Faddy","year":"2000","unstructured":"Faddy MJ. Follicle dynamics during ovarian ageing. Molecular and Cellular Endocrinology200016343\u201348. (https:\/\/doi.org\/10.1016\/s0303-7207(9900238-5)"},{"key":"bib13","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"3361","article-title":"Anti-M\u00fcllerian hormone and ovarian reserve: update on assessing ovarian function","volume":"105","author":"Moolhuijsen","year":"2020","unstructured":"Moolhuijsen LME & Visser JA. Anti-M\u00fcllerian hormone and ovarian reserve: update on assessing ovarian function. Journal of Clinical Endocrinology and Metabolism20201053361\u20133373. 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(https:\/\/doi.org\/10.1210\/jc.2010-0930)"},{"key":"bib15","series-title":"Human Reproduction Update","first-page":"370","article-title":"The physiolo","volume":"20","author":"Dewailly","year":"2014","unstructured":"Dewailly DAndersen CYBalen ABroekmans FDilaver NFanchin RGriesinger GKelsey TWLa Marca ALambalk C, et al.The physiology and clinical utility of anti-Mullerian hormone in women. Human Reproduction Update201420370\u2013385. (https:\/\/doi.org\/10.1093\/humupd\/dmt062)"},{"key":"bib16","series-title":"Thyroid","first-page":"522","article-title":"A single radioactive iodine treatment has a deleterious effect on ovarian reserve in women with thyroid cancer: results of a prospective pilot study","volume":"28","author":"Yaish","year":"2018","unstructured":"Yaish IAzem FGutfeld OSilman ZSerebro MSharon OShefer GLimor RStern N & Tordjman KM. A single radioactive iodine treatment has a deleterious effect on ovarian reserve in women with thyroid cancer: results of a prospective pilot study. Thyroid201828522\u2013527. (https:\/\/doi.org\/10.1089\/thy.2017.0442)"},{"key":"bib17","series-title":"Thyroid","first-page":"1702","article-title":"Effects of radioactive iodine therapy on ovarian reserve: a prospective pilot study","volume":"28","author":"Evranos","year":"2018","unstructured":"Evranos BFaki SPolat SBBestepe NErsoy R & Cakir B. Effects of radioactive iodine therapy on ovarian reserve: a prospective pilot study. Thyroid2018281702\u20131707. (https:\/\/doi.org\/10.1089\/thy.2018.0129)"},{"key":"bib18","article-title":"WHO Adolescent health","unstructured":"WHO Adolescent health [Internet]. Available at: https:\/\/www.who.int\/southeastasia\/health-topics\/adolescent-health(Accessed on January 28 2023)."},{"key":"bib19","series-title":"Thyroid","first-page":"716","article-title":"Management guidelines for children with thyroid nodules and differentiated thyroid cancer","volume":"25","author":"Francis","year":"2015","unstructured":"Francis GLWaguespack SGBauer AJAngelos PBenvenga SCerutti JMDinauer CAHamilton JHay IDLuster M, et al.Management guidelines for children with thyroid nodules and differentiated thyroid cancer. Thyroid201525716\u2013759. (https:\/\/doi.org\/10.1089\/thy.2014.0460)"},{"key":"bib20","series-title":"Geneva S, Organization WH. Research on the Menopause in the 1990s: Report of a WHO Scientific Group","first-page":"1996","article-title":"WHO Scientific Group on Research on the Menopause in the 1990s","year":"1994","unstructured":"WHO Scientific Group on Research on the Menopause in the 1990s. Geneva S, Organization WH. Research on the Menopause in the 1990s: Report of a WHO Scientific Group [Internet]. World Health Organization, p. 19961994. Available at: https:\/\/apps.who.int\/iris\/handle\/10665\/41841"},{"key":"bib21","series-title":"Endocrinology, Diabetes and Metabolism","first-page":"e00021","article-title":"Paediatric anti-M\u00fcllerian hormone measurement: male and female reference intervals established using the automated Beckman Coulter Access AMH assay","volume":"1","author":"Jopling","year":"2018","unstructured":"Jopling HYates ABurgoyne NHayden KChaloner C & Tetlow L. Paediatric anti-M\u00fcllerian hormone measurement: male and female reference intervals established using the automated Beckman Coulter Access AMH assay. Endocrinology, Diabetes and Metabolism20181e00021. 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The effect of radioactive iodine therapy on ovarian function and fertility in female thyroid cancer patients: a systematic review and meta-analysis. Thyroid202131658\u2013668. (https:\/\/doi.org\/10.1089\/thy.2020.0356)"},{"key":"bib24","series-title":"International Journal of Molecular Sciences","first-page":"5128","article-title":"Cytogenetic damage induced by radioiodine therapy: a follow-up case study","volume":"24","author":"Khvostunov","year":"2023","unstructured":"Khvostunov IKNasonova EKrylov VRodichev AKochetova TShepel NKorovchuk OKutsalo PShegai P & Kaprin A. Cytogenetic damage induced by radioiodine therapy: a follow-up case study. International Journal of Molecular Sciences2023245128. (https:\/\/doi.org\/10.3390\/ijms24065128)"},{"key":"bib25","series-title":"Thyroid Research","first-page":"1","article-title":"Cross-sectional and prospective study on anti-M\u00fcllerian hormone changes in a cohort of pre-menopausal women with a history of differentiated thyroid cancer","volume":"13","author":"Mittica","year":"2020","unstructured":"Mittica MDotto AComina MTeliti MMonti E & Giusti M. Cross-sectional and prospective study on anti-M\u00fcllerian hormone changes in a cohort of pre-menopausal women with a history of differentiated thyroid cancer. Thyroid Research2020131. (https:\/\/doi.org\/10.1186\/s13044-020-0075-z)"},{"key":"bib26","series-title":"JBRA Assisted Reproduction","first-page":"215","article-title":"Are age and anti-M\u00fcllerian hormone good predictors of ovarian reserve and response in women undergoing IVF?","volume":"22","author":"Scheffer","year":"2018","unstructured":"Scheffer JABScheffer BScheffer RFlorencio FGrynberg M & Lozano DM. Are age and anti-M\u00fcllerian hormone good predictors of ovarian reserve and response in women undergoing IVF?JBRA Assisted Reproduction201822215\u2013220. (https:\/\/doi.org\/10.5935\/1518-0557.20180043)"},{"key":"bib1","series-title":"Cancers","first-page":"2382","article-title":"Risk of adverse pregnancy outcomes in young women with thyroid cancer: a systematic review and meta-analysis","volume":"14","author":"Moon","year":"2022","unstructured":"Moon SYi KH & Park YJ. Risk of adverse pregnancy outcomes in young women with thyroid cancer: a systematic review and meta-analysis. Cancers2022142382. (https:\/\/doi.org\/10.3390\/cancers14102382)"},{"key":"bib2","series-title":"Scientific Reports","first-page":"3704","article-title":"Radioactive iodine and female fertility","volume":"12","author":"Navarro","year":"2022","unstructured":"Navarro PRocher SMir\u00f3-Mart\u00ednez P & Oltra-Crespo S. Radioactive iodine and female fertility. Scientific Reports2022123704. (https:\/\/doi.org\/10.1038\/s41598-022-07592-8)"},{"key":"bib3","series-title":"Endocrine Connections","first-page":"1283","article-title":"Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine","volume":"10","author":"Adamska","year":"2021","unstructured":"Adamska ATomczuk-Bobik PPop\u0142awska-Kita ABSiewko KBuczy\u0144ska ASzumowski P\u017bukowski \u0141My\u015bliwiec JZbucka-Kr\u0119towska MAdamski M, et al.Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine. Endocrine Connections2021101283\u20131290. (https:\/\/doi.org\/10.1530\/EC-21-0187)"},{"key":"bib4","series-title":"International Journal of Cancer","first-page":"2291","article-title":"Birth rates after radioactive iodine treatment for differentiated thyroid cancer","volume":"141","author":"Anderson","year":"2017","unstructured":"Anderson CEngel SMWeaver MAZevallos JP & Nichols HB. Birth rates after radioactive iodine treatment for differentiated thyroid cancer. International Journal of Cancer20171412291\u20132295. (https:\/\/doi.org\/10.1002\/ijc.30917)"},{"key":"bib5","series-title":"Clinical Endocrinology","first-page":"479","article-title":"A systematic review examining the effects of therapeutic radioactive iodine on ovarian function and future pregnancy in female thyroid cancer survivors","volume":"69","author":"Sawka","year":"2008","unstructured":"Sawka AMLakra DCLea JAlshehri BTsang RWBrierley JDStraus SThabane LGafni AEzzat S, et al.A systematic review examining the effects of therapeutic radioactive iodine on ovarian function and future pregnancy in female thyroid cancer survivors. Clinical Endocrinology200869479\u2013490. 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(https:\/\/doi.org\/10.1002\/pbc.26595)"},{"key":"bib8","series-title":"Journal of Nuclear Medicine","first-page":"460","article-title":"Subsequent fertility and birth histories of children and adolescents treated with 131I for thyroid cancer","volume":"17","author":"Sarkar","year":"1976","unstructured":"Sarkar SDBeierwaltes WHGill SP & Cowley BJ. Subsequent fertility and birth histories of children and adolescents treated with 131I for thyroid cancer. Journal of Nuclear Medicine197617460\u2013464."},{"key":"bib9","series-title":"Journal of Nuclear Medicine","first-page":"669","article-title":"Differentiated thyroid carcinoma in children and adolescents: a 37-year experience in 85 patients","volume":"38","author":"Dottorini","year":"1997","unstructured":"Dottorini MEVignati AMazzucchelli LLomuscio G & Colombo L. Differentiated thyroid carcinoma in children and adolescents: a 37-year experience in 85 patients. Journal of Nuclear Medicine199738669\u2013675."},{"key":"bib10","series-title":"Thyroid","first-page":"1169","article-title":"Long-term effects of radioiodine treatment on female fertility in survivors of childhood differentiated thyroid carcinoma","volume":"30","author":"Nies","year":"2020","unstructured":"Nies MCantineau AEPArts EGJMvan den Berg MHvan Leeuwen FEMuller Kobold ACKlein Hesselink MSBurgerhof JGMBrouwers AHvan Dam EWCM, et al.Long-term effects of radioiodine treatment on female fertility in survivors of childhood differentiated thyroid carcinoma. Thyroid2020301169\u20131176. (https:\/\/doi.org\/10.1089\/thy.2019.0560)"},{"key":"bib11","series-title":"International Journal of Endocrinology","first-page":"7586482","article-title":"Long-term quality of life and pregnancy outcomes of differentiated thyroid cancer survivors treated by total thyroidectomy and I(131) during adolescence and young adulthood","volume":"2016","author":"Metallo","year":"2016","unstructured":"Metallo MGroza LBrunaud LKlein MWeryha G & Feigerlova E. Long-term quality of life and pregnancy outcomes of differentiated thyroid cancer survivors treated by total thyroidectomy and I(131) during adolescence and young adulthood. International Journal of Endocrinology201620167586482. (https:\/\/doi.org\/10.1155\/2016\/7586482)"},{"key":"bib12","series-title":"Molecular and Cellular Endocrinology","first-page":"43","article-title":"Follicle dynamics during ovarian ageing","volume":"163","author":"Faddy","year":"2000","unstructured":"Faddy MJ. Follicle dynamics during ovarian ageing. Molecular and Cellular Endocrinology200016343\u201348. (https:\/\/doi.org\/10.1016\/s0303-7207(9900238-5)"},{"key":"bib13","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"3361","article-title":"Anti-M\u00fcllerian hormone and ovarian reserve: update on assessing ovarian function","volume":"105","author":"Moolhuijsen","year":"2020","unstructured":"Moolhuijsen LME & Visser JA. Anti-M\u00fcllerian hormone and ovarian reserve: update on assessing ovarian function. Journal of Clinical Endocrinology and Metabolism20201053361\u20133373. (https:\/\/doi.org\/10.1210\/clinem\/dgaa513)"},{"key":"bib14","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"5003","article-title":"Serum levels of anti-M\u00fcllerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients","volume":"95","author":"Hagen","year":"2010","unstructured":"Hagen CPAksglaede LS\u00f8rensen KMain KMBoas MCleemann LHolm KGravholt CHAndersson AMPedersen AT, et al.Serum levels of anti-M\u00fcllerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients. Journal of Clinical Endocrinology and Metabolism2010955003\u20135010. 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A single radioactive iodine treatment has a deleterious effect on ovarian reserve in women with thyroid cancer: results of a prospective pilot study. Thyroid201828522\u2013527. (https:\/\/doi.org\/10.1089\/thy.2017.0442)"},{"key":"bib17","series-title":"Thyroid","first-page":"1702","article-title":"Effects of radioactive iodine therapy on ovarian reserve: a prospective pilot study","volume":"28","author":"Evranos","year":"2018","unstructured":"Evranos BFaki SPolat SBBestepe NErsoy R & Cakir B. Effects of radioactive iodine therapy on ovarian reserve: a prospective pilot study. Thyroid2018281702\u20131707. (https:\/\/doi.org\/10.1089\/thy.2018.0129)"},{"key":"bib18","article-title":"WHO Adolescent health","unstructured":"WHO Adolescent health [Internet]. 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