{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:39Z","timestamp":1784557059914,"version":"3.55.0"},"reference-count":37,"publisher":"Bioscientifica","issue":"5","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["etj.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8,28]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Previous reports suggest that a high body mass index (BMI) increases the risk of thyroid carcinoma. However, it remains unclear whether a high BMI is associated with the risk of the\n                      <jats:italic>BRAFV600E<\/jats:italic>\n                      mutation. We aimed to assess whether a high BMI is associated with an increased risk of the\n                      <jats:italic>BRAFV600E<\/jats:italic>\n                      mutation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Methods<\/jats:title>\n                    <jats:p>\n                      We screened 6558 PTC patients who had undergone\n                      <jats:italic>BRAFV600E<\/jats:italic>\n                      mutation testing between January 2009 and December 2017. After exclusion, 6438 PTC patients were enrolled. We used logistic regression, and restricted cubic spline plots of the adjusted odds ratios (ORs) were illustrated to model the relationship between BMI and the\n                      <jats:italic>BRAFV600E<\/jats:italic>\n                      mutation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 6438 patients, 5102 (79.2%) had the\n                      <jats:italic>BRAFV600E<\/jats:italic>\n                      mutation, and 4954 (76.9%) were female. The median BMI was 23.8 (21.6\u201326.2) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . The primary tumor size was \u22641 cm in 4226 patients (65.6%) and &gt;1 cm in 2212 patients (34.4%). The\n                      <jats:italic>BRAFV600E<\/jats:italic>\n                      mutation was significantly associated with high BMI only in patients with a primary tumor size &gt;1 cm (OR: 1.034; 95% CI: 1.003\u20131.065;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.029), whereas no clear association was found in patients with a primary tumor size \u22641 cm (OR: 1.007; 95% CI: 0.984\u20131.030;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.570). Gender was not a significant factor in either group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our study found that a higher BMI was positively associated with the\n                      <jats:italic>BRAFV600E<\/jats:italic>\n                      mutation in patients with a primary tumor size &gt;1 cm. These results suggest that the association between BMI and the\n                      <jats:italic>BRAFV600E<\/jats:italic>\n                      mutation status differs depending on primary tumor size.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>\n                      Obesity has been suggested as a potential risk factor for thyroid carcinoma. The aim of this study was to assess the association between BMI and the\n                      <jats:italic>BRAFV600E<\/jats:italic>\n                      mutation. In this study, the\n                      <jats:italic>BRAFV600E<\/jats:italic>\n                      mutation was significantly associated with a high BMI only in a primary tumor size &gt;1 cm (OR: 1.034;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.029). No clear association was found in patients with a primary tumor size \u22641 cm (OR: 1.007;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.570). The association between BMI and the\n                      <jats:italic>BRAFV600E<\/jats:italic>\n                      mutation status differs depending on the primary tumor size.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/etj-23-0255","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T11:19:33Z","timestamp":1724843973000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":1,"title":["The association between BMI and BRAFV600E mutation may differ by primary tumor size"],"prefix":"10.1530","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6010-5539","authenticated-orcid":true,"given":"Hyunju","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung","family":"Heo","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang-si, Gyeonggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jin","family":"Ryu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology & Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Statistics and Data Center, Samsung Medical Center, Research Institute for Future Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Lyun","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hyuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology & Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology & Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9563-5046","authenticated-orcid":true,"given":"Jae Hoon","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Endocrinology & Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Thyroid","first-page":"1056","article-title":"Increased incidence of thyroid carcinoma in France: a true epidemic or thyroid nodule management effects? 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