{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:49Z","timestamp":1784557069520,"version":"3.55.0"},"reference-count":24,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["etj.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,7]]},"abstract":"<jats:p>\n                    Langerhans cell histiocytosis (LCH) may present as unifocal disease of the suprasellar region, with symptoms and signs of hypopituitarism, arginine vasopressin deficiency (AVP-D), and weight gain. Transcranial biopsy is necessary to define diagnosis and guide treatment decisions, but it is associated with significant morbidity. We describe a patient with Hashimoto thyroiditis and a single hypothalamic mass in whom LCH diagnosis was made by thyroid fine-needle aspiration cytology (FNAC) performed despite nonspecific findings in thyroid imaging, on the basis of a slightly elevated [\n                    <jats:sup>18<\/jats:sup>\n                    F]-fluorodeoxyglucose (FDG) avidity on PET\/CT and volume increase during follow-up.\n                  <\/jats:p>","DOI":"10.1530\/etj-24-0011","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T12:48:13Z","timestamp":1715086093000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":1,"title":["Langerhans cell histiocytosis of the suprasellar region: diagnosis based on thyroid cytology"],"prefix":"10.1530","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3085-2928","authenticated-orcid":true,"given":"Maria","family":"Mavromati","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland"},{"name":"University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verdiana","family":"Caironi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Lugano Regional Hospital, Ente Ospedaliero Cantonale, Via Tesserete Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Essia","family":"Saiji","sequence":"additional","affiliation":[{"name":"Department of Pathology, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland"},{"name":"University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Isabel","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland"},{"name":"University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahan","family":"Momjian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland"},{"name":"University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Andrade-Lopes","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Capucine","family":"Gubert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Stefano","family":"Demarchi","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Endocrine Surgery, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismini","family":"Mainta","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois R","family":"Jornayvaz","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland"},{"name":"University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaveh","family":"Samii","sequence":"additional","affiliation":[{"name":"Department of Hematology, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland"},{"name":"University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Stalder","sequence":"additional","affiliation":[{"name":"Service and Central Laboratory of Hematology, Lausanne University Hospital, rue du Bugnon Lausanne, Switzerland."},{"name":"Service of Hematology and Laboratory of Hematology, Institut Central des H\u00f4pitaux, H\u00f4pital du Valais, Av. du Grand-Champsec, Sion, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Leboulleux","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland"},{"name":"University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Seminars in Ultrasound, CT, and MR","first-page":"215","article-title":"Suprasellar masses: diagnosis and differential diagnosis","volume":"14","author":"Hershey","year":"1993","unstructured":"Hershey BL. 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Ultrasonography and fine needle aspiration cytology of thyroid Langerhans cell histiocytosis lesions. Journal of Medical Ultrasonics202148107\u2013108. (https:\/\/doi.org\/10.1007\/s10396-020-01066-y)"},{"key":"bib17","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"2866","article-title":"Imaging in endocrinology: Langherans cell histiocytosis of the thyroid gland detected by 18FDG-PET\/CT","volume":"92","author":"Giovanella","year":"2007","unstructured":"Giovanella LCeriani LCrippa S & Mazzucchelli L. Imaging in endocrinology: Langherans cell histiocytosis of the thyroid gland detected by 18FDG-PET\/CT. Journal of Clinical Endocrinology and Metabolism2007922866\u20132867. 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Acta Neurochirurgica2003145547\u2013554;554\u2013545. 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