{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:19:20Z","timestamp":1784557160067,"version":"3.55.0"},"reference-count":43,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["etj.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6,13]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The type 2 deiodinase and its Thr92Ala-DIO2 polymorphism have been linked to clinical outcomes in acute lung injury and coronavirus disease 2019 (COVID-19).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective was to identify a potential association between Thr92Ala-DIO2 polymorphism and body composition (appendicular muscle mass, myosteatosis, and fat distribution) and to determine whether they reflect the severity or mortality associated with the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study (June\u2013August 2020), 181 patients hospitalized with moderate-to-severe COVID-19 underwent a non-contrast-enhanced computed tomography (CT) of the thorax to assess body composition, laboratory tests, and genotyping for the Thr92Ala-DIO2 polymorphism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 181 consecutive patients were stratified into three subgroups according to the genotype: Thr\/Thr (\n                      <jats:italic>n<\/jats:italic>\n                      \u2005=\u200564), Thr\/Ala (\n                      <jats:italic>n\u2005<\/jats:italic>\n                      =\u200596), and Ala\/Ala (\n                      <jats:italic>n<\/jats:italic>\n                      \u2005=\u200521). The prevalence of low muscle area (MA) (&lt; 92 cm\u00b2) was 52.5%. Low MA was less frequent in Ala\/Thr patients (44.8%) than in Thr\/Thr (60.9%) or Ala\/Ala patients (61.9%) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.027). Multivariate logistic regression analysis confirmed that the Thr\/Ala allele was associated with a reduced risk of low MA (41% to 69%) and myosteatosis (62% to 72%) compared with Thr\/Thr\u2009+\u2009Ala\/Ala (overdominant model). Kaplan\u2013Meier curves showed that patients with low muscle mass and homozygosity had lower survival rates than the other groups. Notably, the heterozygotes with MA \u226592 cm\u00b2 exhibited the best survival rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Thr92Ala-DIO2 heterozygosity is associated with increased skeletal MA and less myosteatosis in patients with COVID-19. The protective effect of Thr92Ala-DIO2 heterozygosity on COVID-19 mortality is restricted to patients with reduced MA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/etj-24-0068","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T10:13:51Z","timestamp":1718273631000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":0,"title":["Thr92Ala-DIO2 heterozygosity is associated with skeletal muscle mass and myosteatosis in patients with COVID-19"],"prefix":"10.1530","volume":"13","author":[{"given":"Fabyan Esberard de Lima","family":"Beltr\u00e3o","sequence":"first","affiliation":[{"name":"Lauro Wanderley University Hospital, Federal University of Para\u00edba, Jo\u00e3o Pessoa, Para\u00edba, Brazil"},{"name":"University Center of Jo\u00e3o Pessoa \u2013 UNIPE, Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Carvalhal de Almeida","family":"Beltr\u00e3o","sequence":"additional","affiliation":[{"name":"University Center of Jo\u00e3o Pessoa \u2013 UNIPE, Jo\u00e3o Pessoa, PB, Brazil"},{"name":"Post-Graduation Program in Cognitive Neuroscience and Behavior, Psychology Department of the Center of Human Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa, Para\u00edba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Carvalhal","sequence":"additional","affiliation":[{"name":"Center for Biological and Health Sciences, Federal University of Campina Grande, Campina Grande, Para\u00edba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabyanna Lethicia de Lima","family":"Beltr\u00e3o","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Medicine and Health, Medical School of Medicine, Federal University of Bahia, Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocyel de Brito","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Bioregulation Department, Health and Science Institut, Federal University of Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatilla dos Santos","family":"Silva","sequence":"additional","affiliation":[{"name":"Bioregulation Department, Health and Science Institut, Federal University of Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Mariana Pitangueira","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Bioregulation Department, Health and Science Institut, Federal University of Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Lopes","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopharmacology and Molecular Biology, Health Sciences Institute, Federal University of Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Alexandrina Viana de","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopharmacology and Molecular Biology, Health Sciences Institute, Federal University of Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan dos Santos","family":"Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopharmacology and Molecular Biology, Health Sciences Institute, Federal University of Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Hecht","sequence":"additional","affiliation":[{"name":"The Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giciane Carvalho","family":"Vieira","sequence":"additional","affiliation":[{"name":"Post-Graduation Program in Cognitive Neuroscience and Behavior, Psychology Department of the Center of Human Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa, Para\u00edba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria da Concei\u00e7\u00e3o Rodrigues","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Lauro Wanderley University Hospital, Federal University of Para\u00edba, Jo\u00e3o Pessoa, Para\u00edba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio C.","family":"Bianco","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Metabolism, Division of the Biological Sciences, University of Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2900-2099","authenticated-orcid":true,"given":"Helton Estrela","family":"Ramos","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Medicine and Health, Medical School 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