{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:38:15Z","timestamp":1789763895910,"version":"4.0.1"},"reference-count":35,"publisher":"Bioscientifica","issue":"6","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["etj.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10,14]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>When exposed to iodine contrast medium (ICM), thyroid dysfunction may develop, due to excess amounts of iodide. The incidence of contrast-induced thyroid dysfunction has been difficult to interpret, because of the observational and retrospective designs of most previous studies. With the Swedish CArdioPulmonary bioImage Study (SCAPIS), where randomly selected individuals aged 50\u201365 years, underwent contrast-enhanced coronary CT angiography (CCTA), we were able to prospectively assess the incidence, magnitude and clinical impact of contrast-induced thyroid dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 422 individuals, thyroid hormone levels were analysed before and 4\u201312 weeks after CCTA. Thyroid-related patient-reported outcome questionnaires (ThyPRO) at the time of pre and post-CCTA blood samplings were provided by 368 of those individuals. Thyroid peroxidase antibodies (TPOab) were analysed and an ultrasound of the thyroid gland was performed to detect any thyroid nodules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was a small statistically significant effect on thyroid hormone levels but no cases of overt hypo- or hyperthyroidism after ICM. Subclinical hypo- or hyperthyroidism or isolated low\/high levels of free thyroxine (fT4) developed in 3.5% of the population with normal hormone levels pre-CCTA but without any increased thyroid-related symptoms compared to the remaining cohort. Elevated TPOab and being born outside Sweden were risk factors for developing subclinical hypothyroidism. The presence of thyroid nodules was not associated with ICM-induced thyroid dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this prospective study support the notion that in iodine-sufficient countries, ICM-associated thyroid dysfunction is rare, usually mild, self-limiting and oligo\/asymptomatic in subjects aged 50\u201365 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/etj-24-0244","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T10:59:54Z","timestamp":1728903594000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":9,"title":["Effects of iodine contrast media on thyroid function \u2013 a prospective study"],"prefix":"10.1530","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3390-6661","authenticated-orcid":true,"given":"Jeanette","family":"Carlqvist","sequence":"first","affiliation":[{"name":"Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"},{"name":"Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Nyman","sequence":"additional","affiliation":[{"name":"Division of Medical Radiology, Department of Translational Medicine, Sk\u00e5ne University Hospital, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Brandberg","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"},{"name":"Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Filipsson","family":"Nystr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden"},{"name":"Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, V\u00e4stra G\u00f6taland Region, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"},{"name":"Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Archives of Internal Medicine","first-page":"153","article-title":"Association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism","volume":"172","author":"Rhee","year":"2012","unstructured":"Rhee CMBhan IAlexander EK & Brunelli SM. 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Journal of Internal Medicine 2015 278 645\u2013659. (https:\/\/doi.org\/10.1111\/joim.12384)"},{"key":"bib17","series-title":"PLoS One","first-page":"e0265088","article-title":"The value of combining individual and small area sociodemographic data for assessing and handling selective participation in cohort studies: evidence from the Swedish cardiopulmonary BioImage Study","volume":"17","author":"Bonander","year":"2022","unstructured":"Bonander CNilsson ABj\u00f6rk JBlomberg AEngstr\u00f6m GJernberg TSundstr\u00f6m J\u00d6stgren CJBergstr\u00f6m G & Str\u00f6mberg U. The value of combining individual and small area sociodemographic data for assessing and handling selective participation in cohort studies: evidence from the Swedish cardiopulmonary BioImage Study. PLoS One 2022 17 e0265088. 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(https:\/\/doi.org\/10.1016\/S0140-6736(11)60276-6)"},{"key":"bib20","series-title":"Korean Journal of Radiology","first-page":"370","article-title":"Ultrasonography diagnosis and imaging-based management of thyroid nodules: revised Korean society of thyroid radiology consensus statement and recommendations","volume":"17","author":"Shin","year":"2016","unstructured":"Shin JHBaek JHChung JHa EJKim JHLee YHLim HKMoon WJNa DGPark JS, et al. Ultrasonography diagnosis and imaging-based management of thyroid nodules: revised Korean society of thyroid radiology consensus statement and recommendations. Korean Journal of Radiology 2016 17 370\u2013395. 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Clinical Endocrinology and Metabolism","first-page":"13","article-title":"Iodine intake as a determinant of thyroid disorders in populations","volume":"24","author":"Laurberg","year":"2010","unstructured":"Laurberg PCerqueira COvesen LRasmussen LBPerrild HAndersen SPedersen IB & Carl\u00e9 A. Iodine intake as a determinant of thyroid disorders in populations. Best Practice and Research. Clinical Endocrinology and Metabolism 2010 24 13\u201327. (https:\/\/doi.org\/10.1016\/j.beem.2009.08.013)"},{"key":"bib27","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"376","article-title":"A review: radiographic iodinated contrast media-induced thyroid dysfunction","volume":"100","author":"Lee","year":"2015","unstructured":"Lee SYRhee CMLeung AMBraverman LEBrent GA & Pearce EN. A review: radiographic iodinated contrast media-induced thyroid dysfunction. Journal of Clinical Endocrinology and Metabolism 2015 100 376\u2013383. 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