{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:46:12Z","timestamp":1793159172823,"version":"4.5.0"},"reference-count":22,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":307,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hyperthyroidism is characterized by weight fluctuations and overshoot of weight regain following treatment. We aimed to identify parameters predicting peak percentage weight gain (PWG) in the post-treatment period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 110 patients (73 (66.4%) women) with hyperthyroidism 6\u201336 months after treatment initiation. The primary outcome was PWG of \u226510% (group A) or &amp;lt;10% (group B). We performed adjusted analyses by logistic regression with age, sex, disease-related weight loss, hypothyroidism occurrence, free T4 at diagnosis (fT4-t0) and disease duration as independent variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Post-treatment mean (SD) weight gain was 7.4 (5.22) kg, whereas disease-related weight loss was 5.3 (5.15) kg. Group A (52.7% participants) compared to group B had significantly higher median (IQR) fT4-t0 at 47.4 (36.2, 97.2) vs 29.3 (22.8, 40.4) ng\/dL (P &amp;lt; 0.001) and disease-related weight loss at 6.8 (3, 10) vs 2.5 (0, 4.8) kg (P &amp;lt; 0.001) and non-significantly higher presentation free triiodothyronine at 19.6 (10.4, 44.1) vs 11.8 (8.7, 22.9) pg\/mL (P = 0.078) and TRAb at 6.3 (3, 16.1) vs 4.2 (2.4, 8.7) IU\/L (P = 0.093), respectively. Significant predictor variables of post-treatment PWG in logistic regression were disease-related weight loss (OR = 1.23, P = 0.002) and fT4-t0 (OR = 1.04, P = 0.008).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>More than half the patients with hyperthyroidism had \u226510% PWG post-treatment. Indicators of disease severity, namely disease-related weight loss and baseline thyroid hormones, were predictive of excessive weight gain post-treatment and could be utilized for risk stratification and early intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/etj-24-0373","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T10:02:58Z","timestamp":1744797778000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":10,"title":["Severity of thyrotoxicosis is a risk factor for excessive weight gain in treated hyperthyroidism"],"prefix":"10.1530","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2282-0192","authenticated-orcid":true,"given":"Angelos","family":"Kyriacou","sequence":"first","affiliation":[{"name":"School of Medicine, European University Cyprus 1 , ,","place":["Nicosia, Cyprus"]},{"name":"CEDM Centre of Endocrinology, Diabetes & Metabolism 2 , ,","place":["Limassol, Cyprus"]},{"name":"Diabetes, Endocrinology & Obesity Medicine, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust 3 , ,","place":["Salford, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Vryza","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus 1 , ,","place":["Nicosia, Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Kyriacou","sequence":"additional","affiliation":[{"name":"CEDM Centre of Endocrinology, Diabetes & Metabolism 2 , ,","place":["Limassol, Cyprus"]},{"name":"School of Health Sciences, University of Stirling 4 , ,","place":["Stirling, UK"]},{"name":"Center of Excellence in Biobanking and Biomedical Research, University of Cyprus 5 , ,","place":["Nicosia, Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michalis","family":"Picolos","sequence":"additional","affiliation":[{"name":"Alithias Endocrinology Center 6 , ,","place":["Nicosia, Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetris","family":"Lamnisos","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, European University Cyprus 7 , ,","place":["Nicosia, Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5504-5113","authenticated-orcid":true,"given":"Economides","family":"Panayiotis","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus 1 , ,","place":["Nicosia, Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akheel A","family":"Syed","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology & Obesity Medicine, Salford Royal Hospital, Northern Care Alliance NHS Foundation 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