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This is suggested by the frequent situation of patients failing to reach the therapeutic goals of symptom relief and serum TSH control. Thus, an expert task force was approved by the Guidelines Board of the European Thyroid Association to examine the available data and to formulate recommendations based on the available evidence and the experts\u2019 deduction. The task force provides a body of suggestions to optimize the levothyroxine treatment in monotherapy, considering the key point in the individualization of treatment. Furthermore, the nutritional, pharmacological and pathological factors, potentially leading to the increased need for levothyroxine, are discussed, with a specific focus on the use of liquid and softgel formulations of the hormone.<\/jats:p>","DOI":"10.1530\/etj-25-0123","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T09:30:15Z","timestamp":1751880615000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":40,"title":["ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism"],"prefix":"10.1530","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-1649","authenticated-orcid":true,"given":"Marco","family":"Centanni","sequence":"first","affiliation":[{"name":"Sapienza University of Rome, Clinical Endocrinology Unit 1 , , Latina,","place":["AUSL Latina, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Duntas","sequence":"additional","affiliation":[{"name":"Evgenideion Hospital, Unit of Endocrinology, Metabolism and Diabetes, University of Athens 2 , ,","place":["Athens, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Feldt-Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Endocrinology, Rigshospitalet, Copenhagen University Hospital 3 , ,","place":["Copenhagen, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Koehrle","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Experimentelle Endokrinologie, Charit\u00e9 Universit\u00e4tsmedizin Berlin 4 , ,","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin P","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erasmus 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