{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:15:41Z","timestamp":1784200541166,"version":"3.55.0"},"reference-count":51,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thyroid cancers are a complex ecosystem comprising cancer cells along with stromal and immune cells in the tumor microenvironment. In recent years, single-cell RNA sequencing has transformed our understanding of tumor heterogeneity, enabling in-depth analysis of thyroid cancer biology both within and across tumors. In this review, we explore the insights provided by this technology into the study of papillary and anaplastic thyroid carcinomas. We examine the phenotypic heterogeneity observed among cancer cells themselves, as well as the changes orchestrated by tumor cells in stromal and immune populations during cancer progression.<\/jats:p>","DOI":"10.1530\/etj-25-0141","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:11:30Z","timestamp":1782317490000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":0,"title":["Single-cell RNA sequencing: a powerful tool to study heterogeneity in papillary and anaplastic thyroid carcinoma"],"prefix":"10.1530","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7005-722X","authenticated-orcid":true,"given":"Vicente","family":"Rodrigues Marczyk","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center 1 , ,","place":["Houston, USA"]},{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center 2 , ,","place":["Houston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0807-3832","authenticated-orcid":true,"given":"Jennifer Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center 1 , ,","place":["Houston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"2026071606463862500_bib1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41568-023-00598-y","article-title":"Pathogenesis of cancers derived from thyroid follicular cells","volume":"23","author":"Fagin","year":"2023","journal-title":"Nat Rev Cancer"},{"key":"2026071606463862500_bib2","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/thy.2021.0662","article-title":"Thyroid cancer incidence and mortality trends 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