{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:18:37Z","timestamp":1783448317801,"version":"3.55.0"},"reference-count":23,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":108,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Congenital hypothyroidism is a leading cause of preventable intellectual disability. Neonatal screening enables early detection and treatment, ideally before symptoms appear. In France, screening has been part of national public health policy since 1978, relying on standardized protocols to ensure equity of care. However, the actual adherence to these guidelines and potential local adaptations remain undocumented. This study aimed to describe current practices of French Regional Neonatal Screening Centers and assess their conformity with national recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 2024, a cross-sectional descriptive survey was conducted via a structured online questionnaire sent to all 16 French Regional Neonatal Screening Centers. The questionnaire addressed TSH retesting and referral thresholds, use of thyroxine assays, second-tier testing, resampling protocols, and management of preterm infants. Data were analyzed to identify deviations from guidelines and their potential implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All 16 centers responded (100% response rate). Nine (56%) reported deviations from national recommendations. Five centers applied alternative TSH retesting or referral thresholds. Four measured thyroxine on the first dried blood spot for intermediate TSH levels, with one retrospectively evaluating this approach. Three centers had specific resampling protocols for preterm infants, but none used gestational age-adjusted TSH thresholds. These adaptations aimed to reduce false positives and false negatives associated with the standard protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This nationwide survey highlights substantial heterogeneity in congenital hypothyroidism screening practices across France. Variations in TSH thresholds, thyroxine measurement, and preterm infant management may impact diagnostic consistency and equity. Harmonization efforts based on evidence are needed to optimize neonatal screening performance nationally.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/etj-25-0246","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:03:46Z","timestamp":1772031826000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":0,"title":["Newborn screening for congenital hypothyroidism in France: a study of current professional practices"],"prefix":"10.1530","volume":"15","author":[{"given":"Maelle","family":"Quenet","sequence":"first","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Leroux","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Bendavid","sequence":"additional","affiliation":[{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-B\u00e9atrice","family":"Saade","sequence":"additional","affiliation":[{"name":"4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Beuchee","sequence":"additional","affiliation":[{"name":"5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Bellanger","sequence":"additional","affiliation":[{"name":"5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-4078","authenticated-orcid":true,"given":"Caroline","family":"Moreau","sequence":"additional","affiliation":[{"name":"6"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"2026070713595193400_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.860862","article-title":"Congenital hypothyroidism in preterm newborns \u2013 the challenges of diagnostics and treatment: a review","volume":"13","author":"Klosinska","year":"2022","journal-title":"Front Endocrinol"},{"key":"2026070713595193400_bib2","article-title":"Rapport d\u2019activit\u00e9 programme national du d\u00e9pisatge n\u00e9onatal Ann\u00e9e 2023","author":"Centre National de Coodination du D\u00e9pistage N\u00e9onatal","year":"2023"},{"key":"2026070713595193400_bib3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/adc.59.1.23","article-title":"Outcome for congenital hypothyroidism","volume":"59","author":"Hulse","year":"1984","journal-title":"Arch Dis Child"},{"key":"2026070713595193400_bib4","doi-asserted-by":"crossref","DOI":"10.1530\/ETJ-24-0327","article-title":"Newborn screening for congenital hypothyroidism: worldwide coverage 50 years after its start","volume":"14","author":"Arrigoni","year":"2025","journal-title":"Eur Thyroid J"},{"key":"2026070713595193400_bib5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10545-010-9062-1","article-title":"Newborn screening strategies for congenital hypothyroidism: an update","volume":"33","author":"LaFranchi","year":"2010","journal-title":"J Inher Metab Disea"},{"key":"2026070713595193400_bib6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.beem.2013.05.008","article-title":"Screening for congenital hypothyroidism: a worldwide view of strategies","volume":"28","author":"Ford","year":"2014","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2026070713595193400_bib7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.arcped.2022.02.001","article-title":"Neonatal screening for congenital hypothyroidism: time to lower the TSH threshold in France","volume":"29","author":"Levaillant","year":"2022","journal-title":"Arch Pediatr"},{"key":"2026070713595193400_bib8","article-title":"Worldwide recall rate in newborn screening programs for congenital hypothyroidism","volume":"15","author":"Mehran","year":"2017","journal-title":"Int J Endocrinol Metab"},{"key":"2026070713595193400_bib9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1210\/jc.2013-1891","article-title":"European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism","volume":"99","author":"L\u00e9ger","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2026070713595193400_bib10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1297\/cpe.2022-0063","article-title":"Guidelines for newborn screening of congenital hypothyroidism (2021 revision)","volume":"32","author":"Nagasaki","year":"2023","journal-title":"Clin Pediatr Endocrinol"},{"key":"2026070713595193400_bib11","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1210\/jc.2011-1073","article-title":"Is the incidence of congenital hypothyroidism really increasing? A 20-year retrospective population-based study in Qu\u00e9bec","volume":"96","author":"Delado\u00eby","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2026070713595193400_bib12","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1210\/jc.2010-0057","article-title":"Screening for congenital hypothyroidism: the significance of threshold limit in false-negative results","volume":"95","author":"Mengreli","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2026070713595193400_bib13","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1210\/jc.2012-3273","article-title":"Congenital hypothyroidism due to defects of thyroid development and mild increase of TSH at screening: data from the Italian National Registry of infants with congenital hypothyroidism","volume":"98","author":"Olivieri","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2026070713595193400_bib14","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/ejendo\/lvad064","article-title":"Neonatal screening for congenital hypothyroidism in Sweden 1980\u20132013: effects of lowering the thyroid-stimulating hormone threshold","volume":"188","author":"Gunnerbeck","year":"2023","journal-title":"Eur J Endocrinol"},{"key":"2026070713595193400_bib15","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1365-2265.2009.03568.x","article-title":"A 7-year experience with low blood TSH cutoff levels for neonatal screening reveals an unsuspected frequency of congenital hypothyroidism (CH)","volume":"71","author":"Corbetta","year":"2009","journal-title":"Clin Endocrinol"},{"key":"2026070713595193400_bib16","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S2213-8587(16)30122-X","article-title":"Association between borderline neonatal thyroid-stimulating hormone concentrations and educational and developmental outcomes: a population-based record-linkage study","volume":"4","author":"Lain","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2026070713595193400_bib17","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgaa415","article-title":"Newborn screening TSH values less than 15 mIU\/L are not associated with long-term hypothyroidism or cognitive impairment","volume":"105","author":"West","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"2026070713595193400_bib18","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2022-060420","article-title":"Congenital hypothyroidism: screening and management","volume":"151","author":"Rose","year":"2023","journal-title":"Pediatrics"},{"key":"2026070713595193400_bib19","doi-asserted-by":"crossref","first-page":"e338","DOI":"10.1210\/clinem\/dgaa789","article-title":"Newborn screening for congenital hypothyroidism: the benefit of using differential TSH cutoffs in a 2-screen program","volume":"106","author":"Caiulo","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"2026070713595193400_bib20","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1089\/thy.2020.0333","article-title":"Congenital hypothyroidism: a 2020\u20132021 consensus guidelines update-An ENDO-European Reference Network initiative endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology","volume":"31","author":"van Trotsenburg","year":"2021","journal-title":"Thyroid"},{"key":"2026070713595193400_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.686317","article-title":"Diagnosis and management of central congenital hypothyroidism","volume":"12","author":"Lauffer","year":"2021","journal-title":"Front Endocrinol"},{"key":"2026070713595193400_bib22","first-page":"474","article-title":"[Neonatal screening for congenital hypothyroidism]","volume":"37","author":"L\u00e9ger","year":"2021","journal-title":"Med Sci"},{"key":"2026070713595193400_bib23","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/BF02034742","article-title":"Screening for congenital hypothyroidism in France. Misdiagnosed cases: collaborative study of screening centres in France","volume":"149","author":"Leger","year":"1990","journal-title":"Eur J Pediatr"}],"container-title":["European Thyroid Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/etj.bioscientifica.com\/view\/journals\/etj\/15\/2\/ETJ-25-0246.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/etj.bioscientifica.com\/downloadpdf\/journals\/etj\/15\/2\/ETJ-25-0246.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/doi\/10.1530\/ETJ-25-0246\/503264\/etj-25-0246.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/doi\/10.1530\/ETJ-25-0246\/503264\/etj-25-0246.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:00:01Z","timestamp":1783447201000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article\/15\/2\/ETJ250246\/75604\/Newborn-screening-for-congenital-hypothyroidism-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1530\/etj-25-0246","relation":{},"ISSN":["2235-0802","2235-0640"],"issn-type":[{"value":"2235-0802","type":"electronic"},{"value":"2235-0640","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"article-number":"ETJ250246"}}