{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:01:51Z","timestamp":1784646111016,"version":"3.55.0"},"reference-count":44,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":32,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                    <jats:p\/>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:sec>\n                      <jats:title>Objective<\/jats:title>\n                      <jats:p>We aimed to explore the association between thyroid indicators and pre-sarcopenic obesity, pre-sarcopenia, and visceral obesity in a community-based euthyroid cohort.<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Methods<\/jats:title>\n                      <jats:p>A total of 1,280 euthyroid residents (42.3% men) aged over 40 years were recruited in 2013\u20132014 and re-examined in 2015\u20132016. Thyroid indicators were analyzed. Visceral fat area was quantified using magnetic resonance imaging, and skeletal muscle mass was calculated using a bioelectrical impedance analyzer. Pre-sarcopenic obesity was defined as the coexistence of pre-sarcopenia and visceral obesity.<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Results<\/jats:title>\n                      <jats:p>During a mean follow-up of 2.1 years, 127 (14.8%), 156 (21.3%), and 120 (20.1%) participants developed new-onset pre-sarcopenic obesity, pre-sarcopenia, and visceral obesity, respectively. Compared with those with the lowest tertile of baseline serum fT3 levels, participants with the highest tertile had an elevated risk of pre-sarcopenic obesity (risk ratio (RR): 1.82, 95% confidence interval (CI): 1.20\u20132.76) and pre-sarcopenia (RR: 1.49, 95% CI: 1.04\u20132.15). Moreover, a 1 standard deviation increase in serum fT3 levels over 2.1 years was positively associated with incident pre-sarcopenic obesity (RR: 1.40, 95% CI: 1.28\u20131.53) and pre-sarcopenia (RR: 1.29, 95% CI: 1.18\u20131.40), respectively.<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                      <jats:title>Conclusion<\/jats:title>\n                      <jats:p>Elevated serum fT3 levels were associated with increased risks of pre-sarcopenic obesity and pre-sarcopenia in euthyroid Chinese participants.<\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1530\/etj-25-0285","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:19:27Z","timestamp":1781194767000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":0,"title":["Association between thyroid hormone and pre-sarcopenic obesity in euthyroid population: a 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study"],"prefix":"10.1530","volume":"15","author":[{"given":"Tingting","family":"Hu","sequence":"first","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Xu","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoya","family":"Li","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Xiao","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Wang","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4754-3470","authenticated-orcid":true,"given":"Yuqian","family":"Bao","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-161X","authenticated-orcid":true,"given":"Xiaojing","family":"Ma","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"2026072110070916700_bib1","article-title":"World 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