{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:00:27Z","timestamp":1789002027530,"version":"build-2803163510"},"reference-count":29,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":78,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Amiodarone-induced thyrotoxicosis (AIT) affects 5\u201310% of patients on amiodarone therapy, increasing cardiovascular (CV) risk. Total thyroidectomy is proposed for refractory cases, but its long-term impact on major adverse cardiovascular events (MACEs) remains uncertain. This study evaluates post-operative MACEs and cardiac mortality in AIT patients with and without pre-operative left ventricular ejection fraction (LVEF) impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing total thyroidectomy for AIT from 2010 to 2023 in two French referral centers were retrospectively included. They were divided into two groups based on pre-operative LVEF (&amp;lt;40% vs \u226540%). The main outcomes were the post-operative MACEs and cardiac mortality at one and five years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 101 patients, 26 had LVEF &amp;lt; 40% (group 1), while 75 had LVEF \u2265 40% (group 2). Patients in group 1 were younger, had higher ASA (American Society of Anesthesia) scores, and had more severe cardiac conditions. The median duration of exposure to AIT was 2.7 (Q1; Q3 1.3; 4.7) months. Overall, perioperative mortality was 2.0%. Group 1 showed higher 5-year MACE occurrence (61.4 vs 24.0%, P = 0.0005) and higher cardiac mortality (30.8 vs 1.3%, P = 0.0001). Multivariate regression identified younger age at AIT diagnosis and baseline LVEF &amp;lt; 40% as significantly associated with a higher 5-year MACE rate. Among patients with baseline LVEF &amp;lt; 40%, those with early post-operative LVEF improvement displayed a lower rate of 5-year MACEs (47.1 vs 100%, P = 0.022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with LVEF &amp;lt; 40% carries a high long-term CV risk despite early thyroidectomy. Post-operative LVEF assessment may help identify high-risk patients. In contrast, those with LVEF \u2265 40% have a favorable prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/etj-25-0292","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T10:56:02Z","timestamp":1775559362000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":1,"title":["Major adverse cardiac events in patients with amiodarone-induced thyrotoxicosis undergoing thyroidectomy: a multicenter study"],"prefix":"10.1530","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1308-3199","authenticated-orcid":true,"given":"Samuel","family":"Frey","sequence":"first","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Volteau","sequence":"additional","affiliation":[{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Lasolle","sequence":"additional","affiliation":[{"name":"4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Caillard","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Drui","sequence":"additional","affiliation":[{"name":"5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Pattier","sequence":"additional","affiliation":[{"name":"6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Borson-Chazot","sequence":"additional","affiliation":[{"name":"4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Maillard","sequence":"additional","affiliation":[{"name":"7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Lifante","sequence":"additional","affiliation":[{"name":"7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Miralli\u00e9","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"2026070714001389000_bib1","first-page":"240","article-title":"The 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