{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:01:37Z","timestamp":1784646097435,"version":"3.55.0"},"reference-count":30,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82202183, 82071952"],"award-info":[{"award-number":["82202183, 82071952"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the IIT Clinical Research Fund of the Second Affiliated Hospital of Xi'an Jiaotong University","award":["2025IIT-T02"],"award-info":[{"award-number":["2025IIT-T02"]}]},{"name":"the Youth Project of the Hospital Fund of the Second Affiliated Hospital of Xi'an Jiaotong University","award":["YJ(QN) 202525"],"award-info":[{"award-number":["YJ(QN) 202525"]}]}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy and frequently coexists with Hashimoto\u2019s thyroiditis (HT). Clinical observations indicate that HT-PTC tends to display less aggressive clinicopathological features; however, the immune characteristics underlying this phenomenon remain incompletely defined. In this study, we combined transcriptomic analysis with experimental validation to investigate CD8+ T cell features in HT-PTC. Analysis of TCGA data showed increased CD8+ T cell infiltration in HT-PTC compared with non-HT-PTC. In surgically resected specimens from our center, primary CD8+ T cells derived from HT-PTC were further characterized. Tumor-derived CD8+ T cells maintained cytokine secretion capacity and showed lower expression of TIM-3 and LAG-3, together with higher Granzyme B levels. In coculture assays, these cells were associated with reduced proliferation and migration of thyroid cancer cells. Overall, CD8+ T cells in HT-PTC exhibited no pronounced exhaustion-associated feature pattern and retained functional activity. This immune profile may be linked to the relatively less aggressive behavior observed in HT-PTC and provides a biological reference for future immune-informed risk stratification strategies.<\/jats:p>","DOI":"10.1530\/etj-25-0365","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:20:42Z","timestamp":1778174442000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":0,"title":["CD8+ T cells in Hashimoto\u2019s thyroiditis-associated papillary thyroid 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