{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:01:45Z","timestamp":1784646105635,"version":"3.55.0"},"reference-count":37,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":70,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Central congenital hypothyroidism (incidence \u223c1:13,000) occurs in isolation (40% cases) or with additional pituitary hormone deficiencies. T4 \u00b1 TSH-based neonatal screening detects central congenital hypothyroidism within the first two weeks of life, permitting prompt treatment, but the UK TSH-based screening programme will not detect these cases. We delineated clinical characteristics, time-frame and pathway to diagnosis in clinically diagnosed individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Records were reviewed for 118 cases diagnosed from 1996 to 2022, in four tertiary centres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median age at diagnosis was 68 days (range: 1\u20135,056). 96% had combined pituitary hormone deficiencies. Non-specific neonatal concerns (hypoglycaemia\/jaundice\/weight concerns, 83%) and significant neurodevelopmental defects (34%) occurred frequently. Compared with cases diagnosed late (&amp;gt;1 year, n = 42), early diagnosis (\u226414 days n = 23) was associated with neonatal intensive care admission (78 vs 29%, P &amp;lt; 0.001) and ACTH deficiency (96 vs 40% P &amp;lt; 0.0001). Mean FT4 was moderately low at diagnosis (\u22122.7 \u00b1 0.9 SDS), but initial thyroid function was within reported reference ranges in 31 cases. Treatment delays could be substantial, even following detection of subnormal FT4, especially in late-diagnosed cases (mean: 208 \u00b1 486 days).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>UK central congenital hypothyroidism cases are diagnosed later than screening-detected cases, and isolated TSH deficiency may evade detection entirely. \u2018Sicker\u2019 neonates are diagnosed earlier, but late diagnosis frequently occurs despite neonatal\/childhood morbidity attributable to combined pituitary hormone deficiencies. Challenges include non-specific neonatal signs, requirement for bespoke age-specific FT4 reference ranges, lack of biomarkers for alternative diagnoses and masking by concomitant GH deficiency. Our findings mandate further studies to assess practicalities, costs and justification for introducing UK-wide central congenital hypothyroidism screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/etj-26-0014","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:31:12Z","timestamp":1777390272000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective, multicentre evaluation of central congenital hypothyroidism in the UK"],"prefix":"10.1530","volume":"15","author":[{"given":"Catherine","family":"Peters","sequence":"first","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6084-5174","authenticated-orcid":true,"given":"Claire","family":"Wood","sequence":"additional","affiliation":[{"name":"2"},{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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