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The effects of leptin on insulin occur also in the long term, since this hormone inhibits insulin gene expression as well. Additionally, \u03b2-cell mass can be affected by leptin through changes in proliferation, apoptosis, or cell size. All these different functions in the \u03b2-cell are triggered by leptin as a result of the large diversity of signaling pathways that this hormone is able to activate in the endocrine pancreas. Therefore, leptin can participate in glucose homeostasis owing to different levels of modulation of the pancreatic \u03b2-cell population. Furthermore, it has been proposed that alterations in this level of regulation could contribute to the impairment of \u03b2-cell function in obesity states. In the present review, we will discuss all these issues with special emphasis on the effects and pathways of leptin signaling in the pancreatic \u03b2-cell.<\/jats:p>","DOI":"10.1530\/jme-12-0025","type":"journal-article","created":{"date-parts":[[2012,3,24]],"date-time":"2012-03-24T03:37:47Z","timestamp":1332560267000},"page":"R9-R17","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":133,"title":["Role of leptin in the pancreatic \u03b2-cell: effects and signaling 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