{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:18:21Z","timestamp":1784557101152,"version":"3.55.0"},"reference-count":43,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>\n                    During pregnancy, glucocorticoids transfer environmental signals to the growing brain and its associated neuroendocrine system to modulate their maturation and function during adolescence and adulthood. Increased\n                    <jats:italic>in utero<\/jats:italic>\n                    exposure to glucocorticoids is associated with impaired fetal growth resulting in low birth weight (LBW) and compromised neural development. The underlying molecular changes affecting brain development, however, are largely unknown. Here, we compared the relative mRNA expression of genes directly involved in glucocorticoid signaling in the hippocampus, amygdala, and cortex of female non-human primate neonates (\n                    <jats:italic>Macaca fascicularis<\/jats:italic>\n                    ) of naturally occurring normal birth weight and LBW. We focused on the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) genes as well as that for 11\u03b2-hydroxysteroid dehydrogenase type 1 (\n                    <jats:italic>11\u03b2-HSD1<\/jats:italic>\n                    ) and found a significantly decreased MR:GR mRNA ratio in the hippocampus and lower expression of\n                    <jats:italic>11\u03b2-HSD1<\/jats:italic>\n                    in the amygdala associated with LBW. The MR:GR mRNA ratio in the amygdala and cortex was not associated with birth weight, reflecting tissue-specific effects. Protein quantification in the hippocampus confirmed our finding of a decreased hippocampal MR:GR ratio. Our data suggest that the MR:GR ratio in the hippocampus and the expression of\n                    <jats:italic>11\u03b2-HSD1<\/jats:italic>\n                    in the amygdala are associated with intrauterine growth restriction in non-human primates during early perinatal development.\n                  <\/jats:p>","DOI":"10.1530\/jme-12-0218","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T23:16:19Z","timestamp":1366154179000},"page":"59-67","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":7,"title":["Decreased hippocampal mineralocorticoid:glucocorticoid receptor ratio is associated with low birth weight in female cynomolgus macaque neonates"],"prefix":"10.1530","volume":"51","author":[{"given":"Shirlene X","family":"Ong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keefe","family":"Chng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Meaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan P","family":"Buschdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"issue":"5","key":"1_23074251","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1093\/aje\/kwk036","volume":"165","year":"2007","journal-title":"American Journal of Epidemiology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9262","issn-type":"print"},{"issue":"11","key":"2_36618937","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.biopsych.2009.12.016","volume":"67","author":"Arabadzisz","year":"2010","journal-title":"Biological psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3223","issn-type":"print"},{"issue":"6","key":"3_17187566","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1001\/jama.288.6.728","volume":"288","author":"Bhutta","year":"2002","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"key":"4_40771524","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000271911","volume":"73","year":"2010","journal-title":"HORMONE RESEARCH IN PAEDIATRICS"},{"issue":"4","key":"5_11089640","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/S0029-7844(00)01206-0","volume":"97","author":"BLOOM","year":"2001","journal-title":"Obstetrics &amp; Gynecology","ISSN":"https:\/\/id.crossref.org\/issn\/0029-7844","issn-type":"print"},{"issue":"5619","key":"6_17601609","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1126\/science.1080803","volume":"300","author":"Bloomfield","year":"2003","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"2","key":"7_15480494","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0165-3806(94)90192-9","volume":"77","author":"Bohn","year":"1994","journal-title":"Brain research. Developmental brain research","ISSN":"https:\/\/id.crossref.org\/issn\/0165-3806","issn-type":"print"},{"issue":"10","key":"8_23712517","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1523\/JNEUROSCI.3252-06.2007","volume":"27","author":"Buss","year":"2007","journal-title":"Journal of Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0270-6474","issn-type":"print"},{"issue":"10","key":"9_17913040","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/S0006-3223(03)00698-X","volume":"54","author":"Coe","year":"2003","journal-title":"Biological psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3223","issn-type":"print"},{"issue":"5","key":"10_41826544","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1096\/fj.12-203489","volume":"26","year":"2012","journal-title":"The FASEB Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0892-6638","issn-type":"print"},{"key":"11_45902196","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ejpn.2011.05.002","volume":"15","year":"2011","journal-title":"EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY"},{"issue":"2","key":"12_6364078","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0006-8993(99)02064-8","volume":"846","author":"Dean","year":"1999","journal-title":"Brain research","ISSN":"https:\/\/id.crossref.org\/issn\/0006-8993","issn-type":"print"},{"issue":"1 Pt 1","key":"13_10712081","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/S0002-9378(99)70160-2","volume":"180","author":"French","year":"1999","journal-title":"American journal of obstetrics and gynecology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9378","issn-type":"print"},{"issue":"5","key":"14_10648730","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1093\/embo-reports\/kvd088","volume":"1","author":"Gass","year":"2000","journal-title":"EMBO Reports","ISSN":"https:\/\/id.crossref.org\/issn\/1469-221X","issn-type":"print"},{"issue":"5","key":"15_14629205","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1210\/jc.77.5.1174","volume":"77","author":"Goland","year":"1993","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"16_45902197","first-page":"648","volume":"38","year":"2012","journal-title":"Psychoneuroendocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0306-4530","issn-type":"print"},{"key":"17_45902198","first-page":"1","volume":"3","year":"2007","journal-title":"Trends in neurosciences","ISSN":"https:\/\/id.crossref.org\/issn\/0166-2236","issn-type":"print"},{"issue":"6","key":"18_5469978","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1172\/JCI114370","volume":"84","author":"Kalinyak","year":"1989","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"52","key":"19_21149932","doi-asserted-by":"publisher","first-page":"19204","DOI":"10.1073\/pnas.0507572102","volume":"102","year":"2005","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"6","key":"20_16577177","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1159\/000127146","volume":"64","author":"Levitt","year":"1996","journal-title":"Neuroendocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3835","issn-type":"print"},{"issue":"3","key":"21_18778795","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/hipo.20065","volume":"15","author":"Lister","year":"2005","journal-title":"Hippocampus","ISSN":"https:\/\/id.crossref.org\/issn\/1050-9631","issn-type":"print"},{"issue":"6","key":"22_34711463","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/nrn2639","volume":"10","author":"Lupien","year":"2009","journal-title":"Nature reviews. Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/1471-003X","issn-type":"print"},{"issue":"2","key":"23_10492985","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S0306-4522(00)00271-2","volume":"100","author":"Mallard","year":"2000","journal-title":"Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0306-4522","issn-type":"print"},{"issue":"1","key":"24_15843139","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-3806(94)00153-Q","volume":"84","author":"McCormick","year":"1995","journal-title":"Brain research. Developmental brain research","ISSN":"https:\/\/id.crossref.org\/issn\/0165-3806","issn-type":"print"},{"issue":"1","key":"25_10784685","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1146\/annurev.neuro.22.1.105","volume":"22","author":"McEwen","year":"1999","journal-title":"Annual review of neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0147-006X","issn-type":"print"},{"key":"26_45902199","first-page":"4979","volume":"86","year":"2002","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"7","key":"27_29018492","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.molmed.2007.05.003","volume":"13","author":"Meaney","year":"2007","journal-title":"Trends in molecular medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1471-4914","issn-type":"print"},{"issue":"2","key":"28_13006421","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/0014-4886(83)90415-6","volume":"82","author":"Meyer","year":"1983","journal-title":"Experimental neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0014-4886","issn-type":"print"},{"issue":"3","key":"29_11297342","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1677\/joe.0.1700653","volume":"170","author":"Nyirenda","year":"2001","journal-title":"Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"issue":"14","key":"30_17715279","doi-asserted-by":"publisher","first-page":"e73","DOI":"10.1093\/nar\/gng073","volume":"31","author":"Peirson","year":"2003","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"1","key":"31_23531945","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1677\/jme.1.02183","volume":"38","author":"Presul","year":"2007","journal-title":"Journal of Molecular Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0952-5041","issn-type":"print"},{"issue":"2","key":"32_37102029","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.biopsych.2010.02.013","volume":"68","author":"Qiu","year":"2010","journal-title":"Biological psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3223","issn-type":"print"},{"issue":"4366","key":"33_4660160","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1126\/science.705336","volume":"202","author":"Reinisch","year":"1978","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"2","key":"34_10764644","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1042\/bst0270074","volume":"27","author":"Seckl","year":"1999","journal-title":"Biochemical Society Transactions","ISSN":"https:\/\/id.crossref.org\/issn\/1470-8752","issn-type":"print"},{"issue":"5","key":"35_36948408","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/mp.2010.28","volume":"16","author":"Sinclair","year":"2011","journal-title":"Molecular psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/1359-4184","issn-type":"print"},{"issue":"2","key":"36_30900542","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1677\/JOE-07-0375","volume":"197","author":"Sloboda","year":"2008","journal-title":"Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"issue":"2","key":"37_13166713","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/cne.902220208","volume":"222","author":"Szabo","year":"1984","journal-title":"The Journal of comparative neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9967","issn-type":"print"},{"issue":"5","key":"38_11385185","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1192\/bjp.179.5.450","volume":"179","author":"THOMPSON","year":"2001","journal-title":"The British Journal of Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1250","issn-type":"print"},{"issue":"11","key":"39_22947790","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1016\/j.bcp.2006.07.005","volume":"72","author":"Turner","year":"2006","journal-title":"Biochemical pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0006-2952","issn-type":"print"},{"issue":"5","key":"40_5262436","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1523\/JNEUROSCI.09-05-01705.1989","volume":"9","author":"Uno","year":"1989","journal-title":"Journal of Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0270-6474","issn-type":"print"},{"issue":"4","key":"41_15853457","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1006\/hbeh.1994.1030","volume":"28","author":"Uno","year":"1994","journal-title":"Hormones and Behavior (Print)","ISSN":"https:\/\/id.crossref.org\/issn\/1095-6867","issn-type":"print"},{"issue":"1","key":"42_11119409","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0306-4522(01)00065-3","volume":"104","author":"Welberg","year":"2001","journal-title":"Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0306-4522","issn-type":"print"},{"issue":"3","key":"43_38873478","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.yfrne.2010.12.001","volume":"32","author":"Wyrwoll","year":"2011","journal-title":"Frontiers in neuroendocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0091-3022","issn-type":"print"}],"container-title":["Journal of Molecular Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/jme.bioscientifica.com\/view\/journals\/jme\/51\/1\/59.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jme.bioscientifica.com\/downloadpdf\/journals\/jme\/51\/1\/59.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:52:01Z","timestamp":1784555521000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/jme\/article\/51\/1\/59-67\/11358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,16]]},"references-count":43,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/jme-12-0218","relation":{},"ISSN":["0952-5041","1479-6813"],"issn-type":[{"value":"0952-5041","type":"print"},{"value":"1479-6813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,16]]}}}