{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:02:29Z","timestamp":1787583749104,"version":"build-2736575974"},"reference-count":65,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>\n                    The GnRH receptor (GnRHR) is expressed in several non-pituitary tissues, notably in gonads. However, mechanisms underlying the gonad-specific expression of\n                    <jats:italic>Gnrhr<\/jats:italic>\n                    are not well understood. Here,\n                    <jats:italic>Gnrhr<\/jats:italic>\n                    expression was analysed in the developing testes and pituitaries of rats and transgenic mice bearing the human placental alkaline phosphatase reporter gene (\n                    <jats:italic>ALPP<\/jats:italic>\n                    ) under the control of the rat\n                    <jats:italic>Gnrhr<\/jats:italic>\n                    promoter. We showed that the 3.3\u200akb, but not the pituitary-specific 1.1\u200akb promoter, directs\n                    <jats:italic>ALPP<\/jats:italic>\n                    expression exclusively to testis Leydig cells from embryonic day 12 onwards. Real-time PCR analysis revealed that promoter activity displayed the same biphasic profile as marker genes in Leydig cells, i.e. abrupt declines after birth followed by progressive rises after a latency phase, in coherence with the differentiation and evolution of foetal and adult Leydig cell lineages. Interestingly, the developmental profile of transgene expression showed high similarity with the endogenous\n                    <jats:italic>Gnrhr<\/jats:italic>\n                    profile in the rat testis, while mouse\n                    <jats:italic>Gnrhr<\/jats:italic>\n                    was only poorly expressed in the mouse testis. In the pituitary, both transgene and\n                    <jats:italic>Gnrhr<\/jats:italic>\n                    were co-expressed at measurable levels with similar ontogenetic profiles, which were markedly distinct from those in the testis. Castration that induced pituitary\n                    <jats:italic>Gnrhr<\/jats:italic>\n                    up-regulation in rats did not affect the mouse\n                    <jats:italic>Gnrhr<\/jats:italic>\n                    . However, it duly up-regulated the transgene. In addition, in L\u03b2T2 cells, the rat, but not mouse,\n                    <jats:italic>Gnrhr<\/jats:italic>\n                    promoter was sensitive to GnRH agonist stimulation. Collectively, our data highlight inter-species variations in the expression and regulation of\n                    <jats:italic>Gnrhr<\/jats:italic>\n                    in two different organs and reveal that the rat promoter sequence contains relevant genetic information that dictates rat-specific gene expression in the mouse context.\n                  <\/jats:p>","DOI":"10.1530\/jme-12-0231","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T23:25:44Z","timestamp":1364426744000},"page":"411-426","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":6,"title":["Rat Gnrhr promoter directs species-specific gene expression in the pituitary and testes of transgenic mice"],"prefix":"10.1530","volume":"50","author":[{"given":"Muhammad","family":"Ishaq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Schang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange","family":"Magre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-No\u00ebl","family":"Laverri\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Guillou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00eblline","family":"Coudouel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Wargnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Cohen-Tannoudji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Counis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"issue":"10","key":"1_16491694","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1242\/dev.122.10.3319","volume":"122","author":"Alarid","year":"1996","journal-title":"Development","ISSN":"https:\/\/id.crossref.org\/issn\/0950-1991","issn-type":"print"},{"key":"2_45690212","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1210\/en.135.6.2300","volume":"135","year":"1994","journal-title":"Molecular 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