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GNRH has been shown to increase pituitary Adcyap1 gene expression through the interaction of CREB and jun\/fos with CRE\/AP1 cis-elements in the proximal promoter. In these studies, we were interested in identifying additional transcription factors and cognate cis-elements which regulate Adcyap1 gene promoter activity and chose to focus on the GATA family of transcription factors known to be critical for both pituitary cell differentiation and gonadotropin subunit expression. By transient transfection and electrophoretic mobility shift assay analysis, we demonstrate that GATA2 and GATA4 stimulate Adcyap1 promoter activity via a GATA cis-element located at position \u2212191 in the rat Adcyap1 gene promoter. Furthermore, we show that addition of GATA2 or GATA4 significantly augments GNRH-mediated stimulation of Adcyap1 gene promoter activity in the gonadotrope L\u03b2T2 cell line. Conversely, blunting GATA expression with specific siRNA inhibits the ability of GNRH to stimulate ADCYAP1 mRNA levels in these cells. These data demonstrate a complex interaction between GNRH and GATA on ADCYAP1 expression, providing important new insights into the regulation of gonadotrope function.<\/jats:p>","DOI":"10.1530\/jme-13-0089","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T21:15:51Z","timestamp":1378761351000},"page":"313-324","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":9,"title":["GATA augments GNRH-mediated increases in\n                    <i>Adcyap1<\/i>\n                    gene expression in pituitary gonadotrope cells"],"prefix":"10.1530","volume":"51","author":[{"given":"Robin L","family":"Thomas","sequence":"first","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility","department":["Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9032, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie M","family":"Crawford","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility","department":["Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9032, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance M","family":"Grafer","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility","department":["Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9032, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility","department":["Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9032, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M","family":"Halvorson","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility","department":["Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9032, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2026070808261142000_bib1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1210\/me.2002-0386","article-title":"Pituitary adenylate cyclase-activating peptide: a pivotal modulator of steroid-induced reproductive behavior in female rodents","volume":"18","author":"Apostolakis","year":"2004","journal-title":"Molecular 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