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A central role of FOXL2 is the lifetime maintenance of GC identity through the repression of testis-specific genes. Recently, a highly recurrent somatic FOXL2 mutation leading to the p.C134W subtitution has been linked to the development of GC tumours in the adult, which account for up to 5% of ovarian malignancies. In this review, we summarise data on FOXL2 modulators, targets, partners and post-translational modifications. Despite the progresses made thus far, a better understanding of the impact of FOXL2 mutations and of the molecular aspects of its function is required to rationalise its implication in various pathophysiological processes.<\/jats:p>","DOI":"10.1530\/jme-13-0159","type":"journal-article","created":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T23:29:34Z","timestamp":1379546974000},"page":"R17-R33","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":166,"title":["FOXL2: a central transcription factor of the 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