{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:33:11Z","timestamp":1789983191106,"version":"4.0.1"},"reference-count":74,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>Children with inflammatory diseases usually display abnormal growth patterns as well as delayed puberty. This is a result of several factors related to the disease itself, such as malnutrition, hypercortisolism, and elevated levels of pro-inflammatory cytokines. These factors in combination with glucocorticoid treatment contribute to growth retardation during chronic inflammation by systemically affecting the major regulator of growth, the GH\/IGF1 axis. However, recent studies have also shown evidence of a direct effect of these factors at the growth plate level. In conditions of chronic inflammation, pro-inflammatory cytokines are upregulated and released into the circulation. The most abundant of these, tumor necrosis factor \u03b1, interleukin 1\u03b2 (IL1\u03b2), and IL6, are all known to directly act on growth plate cartilage to induce apoptosis and thereby suppress bone growth. Both clinical and experimental studies have shown that growth retardation can partly be rescued when these cytokines are blocked. Therefore, therapy modulating the local actions of these cytokines may be effective for preventing growth failure in patients with chronic inflammatory disorders. In this review, we report the current knowledge of inflammatory cytokines and their role in regulating bone growth.<\/jats:p>","DOI":"10.1530\/jme-14-0006","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T01:17:36Z","timestamp":1396919856000},"page":"T35-T44","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":95,"title":["RECENT RESEARCH ON THE GROWTH PLATE: Impact of inflammatory cytokines on longitudinal bone growth"],"prefix":"10.1530","volume":"53","author":[{"given":"Bettina","family":"Sederquist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Fernandez-Vojvodich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farasat","family":"Zaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"S\u00e4vendahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"issue":"7","key":"1_43056707","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/MCG.0b013e318247c32f","volume":"46","author":"Abraham","year":"2012","journal-title":"Journal of clinical gastroenterology","ISSN":"https:\/\/id.crossref.org\/issn\/0192-0790","issn-type":"print"},{"issue":"3","key":"2_37633701","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1677\/JOE-10-0045","volume":"206","year":"2010","journal-title":"Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"key":"3_42806473","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000229763","volume":"72","year":"2009","journal-title":"Hormone research","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"key":"4_48327479","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1159\/000342529","volume":"106","year":"2013","journal-title":"World review of nutrition and dietetics","ISSN":"https:\/\/id.crossref.org\/issn\/0084-2230","issn-type":"print"},{"key":"5_48327480","first-page":"29","volume":"16","year":"2013","journal-title":"Paediatric drugs","ISSN":"https:\/\/id.crossref.org\/issn\/1174-5878","issn-type":"print"},{"issue":"5","key":"6_10312581","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1136\/gut.46.5.695","volume":"46","author":"Ballinger","year":"2000","journal-title":"Gut","ISSN":"https:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"key":"7_46099682","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000229758","volume":"72","year":"2009","journal-title":"Hormone research","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"issue":"8","key":"8_28779791","doi-asserted-by":"publisher","first-page":"3013","DOI":"10.1210\/jc.2007-0544","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"1","key":"9_35720640","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1677\/JOE-09-0307","volume":"204","year":"2010","journal-title":"Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"key":"10_48327481","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1385\/ENDO:18:3:271","volume":"18","year":"2002","journal-title":"Endocrine","ISSN":"https:\/\/id.crossref.org\/issn\/0969-711X","issn-type":"print"},{"issue":"3","key":"11_17535221","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1677\/joe.0.1760331","volume":"176","author":"Chrysis","year":"2003","journal-title":"Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"issue":"3","key":"12_18724026","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1210\/en.2004-1152","volume":"146","year":"2005","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"1","key":"13_35230822","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000224334","volume":"72","author":"Riepe","year":"2009","journal-title":"Hormone research","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"issue":"4","key":"14_16699325","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1172\/JCI119207","volume":"99","author":"De Benedetti","year":"1997","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"11","key":"15_11363744","doi-asserted-by":"publisher","first-page":"4818","DOI":"10.1210\/en.142.11.4818","volume":"142","author":"De Benedetti","year":"2001","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"key":"16_48327482","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4103\/0378-6323.33633","volume":"73","year":"2007","journal-title":"INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY AND LEPROLOGY"},{"issue":"4","key":"17_42834240","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1159\/000336766","volume":"85","author":"Ezri","year":"2012","journal-title":"Digestion","ISSN":"https:\/\/id.crossref.org\/issn\/0012-2823","issn-type":"print"},{"key":"18_46456779","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00467-012-2271-0","volume":"28","year":"2013","journal-title":"Pediatric nephrology (Berlin, Germany)","ISSN":"https:\/\/id.crossref.org\/issn\/0931-041X","issn-type":"print"},{"issue":"12","key":"19_30013595","first-page":"2481","volume":"34","author":"Vojvodich","year":"2007","journal-title":"The Journal of Rheumatology","ISSN":"https:\/\/id.crossref.org\/issn\/0315-162X","issn-type":"print"},{"key":"20_48327483","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1159\/000330726","volume":"76","year":"2011","journal-title":"HORMONE RESEARCH IN PAEDIATRICS"},{"key":"21_48327484","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000337569","volume":"77","year":"2012","journal-title":"HORMONE RESEARCH IN PAEDIATRICS"},{"issue":"10","key":"22_46163278","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.1136\/annrheumdis-2013-204112","volume":"72","year":"2013","journal-title":"Annals of the Rheumatic Diseases","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4967","issn-type":"print"},{"issue":"1","key":"23_39108966","first-page":"104","volume":"29","author":"Gaspari","year":"2011","journal-title":"Clinical and experimental rheumatology","ISSN":"https:\/\/id.crossref.org\/issn\/0392-856X","issn-type":"print"},{"issue":"9","key":"24_32278658","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1515\/JPEM.2008.21.9.879","volume":"21","author":"Gat-Yablonski","year":"2008","journal-title":"The Journal of pediatric endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0334-018X","issn-type":"print"},{"issue":"5","key":"25_40974887","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.pcl.2011.07.008","volume":"58","author":"Gat-Yablonski","year":"2011","journal-title":"Pediatric clinics of North America","ISSN":"https:\/\/id.crossref.org\/issn\/0031-3955","issn-type":"print"},{"issue":"3","key":"26_28746199","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1152\/physiolgenomics.00022.2007","volume":"30","year":"2007","journal-title":"Physiological Genomics","ISSN":"https:\/\/id.crossref.org\/issn\/1094-8341","issn-type":"print"},{"key":"27_43836661","first-page":"w13650","volume":"142","author":"Hardy","year":"2012","journal-title":"Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology","ISSN":"https:\/\/id.crossref.org\/issn\/1424-7860","issn-type":"print"},{"issue":"7","key":"28_18090266","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1128\/MCB.24.7.2593-2604.2004","volume":"24","author":"Hong","year":"2004","journal-title":"Molecular and Cellular Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-7306","issn-type":"print"},{"issue":"11","key":"29_18515270","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1002\/art.20611","volume":"50","author":"Ikeda","year":"2004","journal-title":"Arthritis and rheumatism","ISSN":"https:\/\/id.crossref.org\/issn\/0004-3591","issn-type":"print"},{"issue":"4551","key":"30_8661098","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1126\/science.7079756","volume":"216","author":"Isaksson","year":"1982","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"4","key":"31_4864627","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1210\/endo-122-4-1515","volume":"122","author":"ISGAARD","year":"1988","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"key":"32_46927539","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ijdevneu.2012.09.001","volume":"30","year":"2012","journal-title":"International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0736-5748","issn-type":"print"},{"issue":"2","key":"33_11477441","doi-asserted-by":"publisher","first-page":"R528","DOI":"10.1152\/ajpregu.00085.2001","volume":"282","author":"Kritsch","year":"2002","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology","ISSN":"https:\/\/id.crossref.org\/issn\/0363-6119","issn-type":"print"},{"issue":"6937","key":"34_17629262","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/nature01657","volume":"423","author":"Kronenberg","year":"2003","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"issue":"4","key":"35_19153211","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000084684","volume":"63","author":"Kugelberg","year":"2005","journal-title":"Hormone research","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"issue":"12","key":"36_6499520","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1056\/NEJM200003233421204","volume":"342","author":"Lai","year":"2000","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"1","key":"37_11029097","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1210\/er.22.1.53","volume":"22","author":"Le Roith","year":"2001","journal-title":"Endocrine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0163-769X","issn-type":"print"},{"issue":"1","key":"38_17756942","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00281-003-0125-3","volume":"25","author":"Li","year":"2003","journal-title":"Springer seminars in immunopathology","ISSN":"https:\/\/id.crossref.org\/issn\/0344-4325","issn-type":"print"},{"issue":"1","key":"39_18020839","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1359\/JBMR.0301206","volume":"19","author":"Locker","year":"2004","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"5","key":"40_30986716","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1002\/art.23427","volume":"58","author":"Lovell","year":"2008","journal-title":"Arthritis and rheumatism","ISSN":"https:\/\/id.crossref.org\/issn\/0004-3591","issn-type":"print"},{"issue":"1","key":"41_11009386","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1006\/dbio.2000.9975","volume":"229","author":"Lupu","year":"2001","journal-title":"Developmental biology","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1606","issn-type":"print"},{"key":"42_46456787","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biocel.2007.06.009","volume":"40","year":"2008","journal-title":"INTERNATIONAL JOURNAL OF BIOCHEMISTRY CELL BIOLOGY"},{"issue":"6","key":"43_22949614","first-page":"1011","volume":"18","author":"Macrae","year":"2006","journal-title":"International journal of molecular medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1107-3756","issn-type":"print"},{"issue":"2","key":"44_22047836","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1677\/joe.1.06609","volume":"189","author":"MacRae","year":"2006","journal-title":"Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"key":"45_44432907","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ghir.2007.05.002","volume":"17","year":"2007","journal-title":"GROWTH HORMONE IGF RESEARCH"},{"issue":"4","key":"46_17256639","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1159\/000065487","volume":"58","author":"Mainardi","year":"2002","journal-title":"Hormone research","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"key":"47_48327485","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.crohns.2011.09.004","volume":"6","year":"2012","journal-title":"JOURNAL OF CROHNS COLITIS"},{"key":"48_47147319","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000342545","volume":"106","year":"2013","journal-title":"World review of nutrition and dietetics","ISSN":"https:\/\/id.crossref.org\/issn\/0084-2230","issn-type":"print"},{"key":"49_48327486","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/MED.0b013e32834ed61f","volume":"19","year":"2012","journal-title":"CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY"},{"issue":"11","key":"50_18467437","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1359\/JBMR.040805","volume":"19","author":"M\u00a0\u00a0rtensson","year":"2004","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"2","key":"51_17162611","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1136\/adc.87.2.93","volume":"87","author":"Mushtaq","year":"2002","journal-title":"Archives of Disease in Childhood","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9888","issn-type":"print"},{"issue":"2","key":"52_35092610","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.cyto.2009.05.002","volume":"47","author":"Nakajima","year":"2009","journal-title":"Cytokine","ISSN":"https:\/\/id.crossref.org\/issn\/1043-4666","issn-type":"print"},{"issue":"4763","key":"53_13870332","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1126\/science.3523759","volume":"233","author":"Nilsson","year":"1986","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"1-2","key":"54_26787779","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.mce.2006.11.006","volume":"264","author":"Owen","year":"2007","journal-title":"Molecular and cellular endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0303-7207","issn-type":"print"},{"issue":"11","key":"55_42091559","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.jnutbio.2011.09.010","volume":"23","author":"Pando","year":"2012","journal-title":"The Journal of nutritional biochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0955-2863","issn-type":"print"},{"issue":"1","key":"56_28933709","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1677\/JOE-07-0012","volume":"194","author":"Parker","year":"2007","journal-title":"Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"issue":"9","key":"57_18837335","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1084\/jem.20050473","volume":"201","year":"2005","journal-title":"Journal of Experimental Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1007","issn-type":"print"},{"issue":"3","key":"58_34487240","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/cbf.1551","volume":"27","author":"Pass","year":"2009","journal-title":"Cell biochemistry and function","ISSN":"https:\/\/id.crossref.org\/issn\/0263-6484","issn-type":"print"},{"issue":"5","key":"59_41785689","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/jbmr.1544","volume":"27","author":"Pass","year":"2012","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"2","key":"60_16769821","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3109\/03009749709115826","volume":"26","author":"Polito","year":"1997","journal-title":"Scandinavian journal of rheumatology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-9742","issn-type":"print"},{"issue":"6","key":"61_3370530","first-page":"825","volume":"49","author":"Salmon","year":"1957","journal-title":"The Journal of laboratory and clinical medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2143","issn-type":"print"},{"key":"62_48327487","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S8756-3282(02)00696-8","volume":"30","year":"2002","ISSN":"https:\/\/id.crossref.org\/issn\/8756-3282","issn-type":"print"},{"issue":"6","key":"63_18009624","first-page":"779","volume":"21","author":"Schmeling","year":"2003","journal-title":"Clinical and experimental rheumatology","ISSN":"https:\/\/id.crossref.org\/issn\/0392-856X","issn-type":"print"},{"key":"64_48327488","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.1097\/MPG.0b013e3181f7feef","volume":"51","year":"2010","journal-title":"Journal of pediatric gastroenterology and nutrition","ISSN":"https:\/\/id.crossref.org\/issn\/0277-2116","issn-type":"print"},{"issue":"6","key":"65_17100185","first-page":"1296","volume":"29","author":"Simon","year":"2002","journal-title":"The Journal of Rheumatology","ISSN":"https:\/\/id.crossref.org\/issn\/0315-162X","issn-type":"print"},{"issue":"7","key":"66_28532640","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1210\/jc.2006-2877","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"6","key":"67_18874624","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1093\/rheumatology\/keh592","volume":"44","year":"2005","journal-title":"Rheumatology","ISSN":"https:\/\/id.crossref.org\/issn\/0080-2727","issn-type":"print"},{"issue":"1","key":"68_45638650","doi-asserted-by":"publisher","first-page":"E15","DOI":"10.1152\/ajpendo.00335.2012","volume":"305","year":"2013","journal-title":"American Journal of Physiology - Endocrinology And Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0193-1849","issn-type":"print"},{"issue":"8","key":"69_21539726","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1136\/ard.2005.047225","volume":"65","year":"2006","journal-title":"Annals of the Rheumatic Diseases","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4967","issn-type":"print"},{"issue":"2","key":"70_18033093","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1677\/joe.0.1800247","volume":"180","author":"Wang","year":"2004","journal-title":"Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"issue":"7006","key":"71_16048088","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1136\/bmj.311.7006.663","volume":"311","author":"Warner","year":"1995","journal-title":"BMJ","ISSN":"https:\/\/id.crossref.org\/issn\/0959-8138","issn-type":"print"},{"key":"72_40641356","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000328119","volume":"21","author":"Wit","year":"2011","journal-title":"Endocrine development","ISSN":"https:\/\/id.crossref.org\/issn\/1421-7082","issn-type":"print"},{"issue":"3","key":"73_42224737","doi-asserted-by":"crossref","first-page":"e33168","DOI":"10.1371\/journal.pone.0033168","volume":"7","author":"Zaman","year":"2012","ISSN":"https:\/\/id.crossref.org\/issn\/1932-6203","issn-type":"print"},{"key":"74_48327489","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.toxlet.2013.10.020","volume":"224","year":"2014","journal-title":"Toxicology letters","ISSN":"https:\/\/id.crossref.org\/issn\/0378-4274","issn-type":"print"}],"container-title":["Journal of Molecular Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/jme.bioscientifica.com\/view\/journals\/jme\/53\/1\/T35.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jme.bioscientifica.com\/downloadpdf\/journals\/jme\/53\/1\/T35.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:52:21Z","timestamp":1784555541000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/jme\/article\/53\/1\/T35-T44\/11501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,7]]},"references-count":74,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/jme-14-0006","relation":{},"ISSN":["0952-5041","1479-6813"],"issn-type":[{"value":"0952-5041","type":"print"},{"value":"1479-6813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,7]]}}}