{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:51Z","timestamp":1784557071519,"version":"3.55.0"},"reference-count":48,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>\n                    Tumor malignancy is associated with the epithelial\u2013mesenchymal transition (EMT) process and resistance to chemotherapy. However, little is known about the relationship between the EMT and the multidrug-resistance gene in thyroid tumor progression. We investigated whether the expression of the\n                    <jats:italic>ABCG2<\/jats:italic>\n                    \/\n                    <jats:italic>BCRP<\/jats:italic>\n                    gene is associated with\n                    <jats:italic>ZEB1<\/jats:italic>\n                    and other EMT inducer genes involved in tumor dedifferentiation. We established a subpopulation of cells that express the\n                    <jats:italic>ABCG2<\/jats:italic>\n                    \/\n                    <jats:italic>BCRP<\/jats:italic>\n                    gene derived from the thyroid papillary carcinoma cell line (TPC-1), the so-called TPC-1 MITO-resistant subline. The most relevant findings in these TPC-1 selected cells were a statistically significant upregulation of\n                    <jats:italic>ZEB1<\/jats:italic>\n                    and\n                    <jats:italic>TWIST1<\/jats:italic>\n                    (35- and 15-fold change respectively), no changes in the relative expression of vimentin and\n                    <jats:italic>SNAIL1<\/jats:italic>\n                    , and no expression of E-cadherin. The TPC-1 MITO-resistant subline displayed a faster migration and greater invasive ability than parental cells in correlation with a significant upregulation of the survivin (\n                    <jats:italic>BIRC5<\/jats:italic>\n                    ) gene (twofold change,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). The knockdown of\n                    <jats:italic>ZEB1<\/jats:italic>\n                    promoted nuclear re-expression of E-cadherin, reduced expression of vimentin, N-cadherin, and\n                    <jats:italic>BIRC5<\/jats:italic>\n                    genes, and reduced cell migration (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Analysis of human thyroid carcinoma showed a slight overexpression of the\n                    <jats:italic>ABCG2<\/jats:italic>\n                    \/\n                    <jats:italic>BCRP<\/jats:italic>\n                    at stages I and II (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01), and a higher overexpression at stages III and IV (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01).\n                    <jats:italic>SNAIL1<\/jats:italic>\n                    ,\n                    <jats:italic>TWIST1<\/jats:italic>\n                    , and\n                    <jats:italic>ZEB1<\/jats:italic>\n                    genes showed higher expression at stages III and IV than at stages I and II. E- and N-cadherin genes were upregulated at stages I and II of the disease (ninefold and tenfold change, respectively,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01) but downregulated at stages III and IV (fourfold lower,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01). These results could be a promising starting point for further study of the role of the\n                    <jats:italic>ABCG2<\/jats:italic>\n                    \/\n                    <jats:italic>BCRP<\/jats:italic>\n                    gene in the progression of thyroid tumor.\n                  <\/jats:p>","DOI":"10.1530\/jme-14-0051","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T23:31:56Z","timestamp":1395185516000},"page":"289-300","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":23,"title":["ABCG2\/BCRP gene expression is related to epithelial\u2013mesenchymal transition inducer genes in a papillary thyroid carcinoma cell line (TPC-1)"],"prefix":"10.1530","volume":"52","author":[{"given":"E","family":"Mato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Moral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J I","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Lerma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"de Leiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"1_47805623","doi-asserted-by":"crossref","first-page":"e352","DOI":"10.1038\/cddis.2012.93","volume":"3","year":"2012","journal-title":"CELL DEATH DISEASE"},{"issue":"14","key":"2_35240256","doi-asserted-by":"publisher","first-page":"5820","DOI":"10.1158\/0008-5472.CAN-08-2819","volume":"69","year":"2009","journal-title":"Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"issue":"3","key":"3_34190491","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/nbt.1527","volume":"27","author":"Blum","year":"2009","journal-title":"Nature biotechnology","ISSN":"https:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"4","key":"4_30413517","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1002\/gcc.20533","volume":"47","author":"Boidot","year":"2008","journal-title":"Genes, chromosomes &amp; cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1045-2257","issn-type":"print"},{"issue":"9","key":"5_19394420","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/nrc1694","volume":"5","author":"Brabletz","year":"2005","journal-title":"Nature reviews. 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