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MR expression is increased in adipose tissue of murine models of obesity and in obese human subjects, suggesting that over-activation of the mineralocorticoid signaling leads to dysfunctional adipocyte and associated metabolic disorders. Notably, pharmacological blockade of MR prevents metabolic dysfunctions observed in obese mice and suggests a potential therapeutic use of MR antagonists in the treatment of obesity and metabolic syndrome. However, the molecular pathways affected by MR blockade have been poorly investigated. This review summarizes the functions of MR in the adipocyte, discusses potential signaling pathways mediating MR action, and describes post-translational modifications regulating its activity.<\/jats:p>","DOI":"10.1530\/jme-15-0122","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T22:49:54Z","timestamp":1439506194000},"page":"R1-R10","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":29,"title":["Cellular mechanisms of MR regulation of adipose tissue physiology and pathophysiology"],"prefix":"10.1530","volume":"55","author":[{"given":"Andrea","family":"Armani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Marzolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fabbri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Caprio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2015110216260166000_55.2.R1.1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22598"},{"key":"2015110216260166000_55.2.R1.2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-245415"},{"key":"2015110216260166000_55.2.R1.3","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2014.68"},{"key":"2015110216260166000_55.2.R1.4","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5.8.9991"},{"key":"2015110216260166000_55.2.R1.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(97)00115-9"},{"key":"2015110216260166000_55.2.R1.6","doi-asserted-by":"crossref","unstructured":"Banks AS McAllister FE Camporez JP Zushin PJ Jurczak MJ Laznik-Bogoslavski D Shulman GI Gygi SP Spiegelman BM 2015 An ERK\/Cdk5 axis controls the diabetogenic actions of PPAR\u03b3. 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