{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:19:59Z","timestamp":1784557199560,"version":"3.55.0"},"reference-count":25,"publisher":"Bioscientifica","issue":"4","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\n                    This study investigates the effectiveness and mechanisms of a serum- and glucocorticoid-inducible kinase 1 (SGK1) inhibitor in counteracting hyperglycemia. In an\n                    <jats:italic>in vivo<\/jats:italic>\n                    experiment, we demonstrated that after an 8-week treatment with an SGK1 inhibitor, the fasting blood glucose and HbA1c level significantly decreased in\n                    <jats:italic>db\/db<\/jats:italic>\n                    mice. RT-PCR and western blot analyses revealed that intestinal SGK1 and sodium glucose co-transporter 1 (SGLT1) expression were enhanced in\n                    <jats:italic>db\/db<\/jats:italic>\n                    mice. Treatment with an SGK1 inhibitor decreased excessive SGLT1 expression in the intestine of\n                    <jats:italic>db\/db<\/jats:italic>\n                    mice.\n                    <jats:italic>In vitro<\/jats:italic>\n                    experiments with intestinal IEC-6 cells showed that the co-administration of an SGK1 inhibitor partly reversed the SGLT1 expression and glucose absorption that were induced by dexamethasone. In conclusion, this study revealed that the favorable effect of an SGK1 inhibitor on hyperglycemia is partly due to decreased glucose absorption through SGLT1 in the small intestine. These data collectively suggest that SGK1 may be a potent target for the treatment of diabetes and other metabolic disorders.\n                  <\/jats:p>","DOI":"10.1530\/jme-15-0285","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T00:07:47Z","timestamp":1465603667000},"page":"301-309","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":22,"title":["SGK1 inhibitor reverses hyperglycemia partly through decreasing glucose absorption"],"prefix":"10.1530","volume":"56","author":[{"given":"Ping","family":"Li","sequence":"first","affiliation":[{"name":"Department of EndocrinologyDrum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of EndocrinologyDrum Tower Hospital Affiliated to Nanjing University 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