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Tissue-selective and mineralocorticoid-specific effects are conferred through the enzyme 11\u03b2-hydroxysteroid dehydrogenase 2, cellular redox status and properties of the MR itself. Furthermore, not all aldosterone effects are mediated via MR, with implication of the involvement of other membrane-bound receptors such as GPER. This review will describe the ligands, receptors and intracellular mechanisms available for mineralocorticoid hormone and receptor signalling and illustrate their complex interactions in physiology and disease.<\/jats:p>","DOI":"10.1530\/jme-15-0318","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T22:14:22Z","timestamp":1478556862000},"page":"R33-R57","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":71,"title":["Mineralocorticoid regulation of cell function: the role of rapid signalling and gene transcription pathways"],"prefix":"10.1530","volume":"58","author":[{"given":"Gregory S Y","family":"Ong","sequence":"first","affiliation":[{"name":"1Cardiovascular Endocrinology LaboratoryCentre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia"},{"name":"2Department of MedicineSchool of Clinical Sciences, Monash University, Clayton, Victoria, 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