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Under physiological conditions, autophagy is an essential homeostatic mechanism to maintain the global cardiac structure function by ridding damaged cells or unwanted macromolecules and organelles. Dysregulation of autophagy may play an important role in Ang II-induced cardiac hypertrophy although conflicting reports on the effects of Ang II on autophagy and cardiac hypertrophy exist. Some studies showed that autophagy activation attenuated Ang II-induced cardiac dysfunction. Others suggested that inhibition of the Ang II induced autophagy should be protective. The discrepancies may be due to different model systems and different signaling pathway involved. Ang II-induced cardiac hypertrophy may be alleviated through regulation of autophagy. This review focuses on Ang II to highlight the molecular targets and pathways identified in the prevention and treatment of Ang II-induced pathological cardiac hypertrophy by regulating autophagy.<\/jats:p>","DOI":"10.1530\/jme-16-0086","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T21:49:54Z","timestamp":1473716994000},"page":"R143-R152","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":69,"title":["The role of autophagy in angiotensin II-induced pathological cardiac hypertrophy"],"prefix":"10.1530","volume":"57","author":[{"given":"Lichun","family":"Zhou","sequence":"first","affiliation":[{"name":"1Department of PharmacologySchool of Pharmaceutical Sciences, Shandong University, Jinan, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohua","family":"Ma","sequence":"additional","affiliation":[{"name":"2Pharmaceutical Preparation SectionCentral Hospital of Qingdao, Qingdao, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzhen","family":"Han","sequence":"additional","affiliation":[{"name":"1Department of PharmacologySchool of Pharmaceutical Sciences, Shandong University, Jinan, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2016100519282720000_57.4.R143.1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr015"},{"key":"2016100519282720000_57.4.R143.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.12.018"},{"key":"2016100519282720000_57.4.R143.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.07.003"},{"key":"2016100519282720000_57.4.R143.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.04.005"},{"key":"2016100519282720000_57.4.R143.5","doi-asserted-by":"publisher","DOI":"10.1177\/1535370214542071"},{"key":"2016100519282720000_57.4.R143.6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064757"},{"key":"2016100519282720000_57.4.R143.7","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.007120"},{"key":"2016100519282720000_57.4.R143.8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.232306"},{"key":"2016100519282720000_57.4.R143.9","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.8.15813"},{"key":"2016100519282720000_57.4.R143.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2010.11.016"},{"key":"2016100519282720000_57.4.R143.11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00149.2014"},{"key":"2016100519282720000_57.4.R143.12","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4604"},{"key":"2016100519282720000_57.4.R143.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.10.013"},{"key":"2016100519282720000_57.4.R143.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2015.05.003"},{"key":"2016100519282720000_57.4.R143.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.08.006"},{"key":"2016100519282720000_57.4.R143.16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00428.2011"},{"key":"2016100519282720000_57.4.R143.17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068697"},{"key":"2016100519282720000_57.4.R143.18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303788"},{"key":"2016100519282720000_57.4.R143.19","doi-asserted-by":"publisher","DOI":"10.4161\/auto.24273"},{"key":"2016100519282720000_57.4.R143.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.06.006"},{"key":"2016100519282720000_57.4.R143.21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1470320314562060","article-title":"Role of MiR-30a in cardiomyocyte autophagy induced by Angiotensin II","volume":"16","author":"Huang","year":"2015","journal-title":"Journal of Renin-Angiotensin-Aldosterone System"},{"key":"2016100519282720000_57.4.R143.22","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000306"},{"key":"2016100519282720000_57.4.R143.23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094382"},{"key":"2016100519282720000_57.4.R143.24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbadis.2014.06.025","article-title":"Autophagy: a housekeeper in cardiorenal metabolic health and disease","volume":"1852","author":"Jia","year":"2015","journal-title":"Biochimica et Biophysica Acta"},{"key":"2016100519282720000_57.4.R143.25","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20111451"},{"key":"2016100519282720000_57.4.R143.26","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmw025"},{"key":"2016100519282720000_57.4.R143.27","doi-asserted-by":"crossref","unstructured":"Li Z Song Y Liu L Hou N An X Zhan D Li Y Zhou L Li P Yu L 2015a miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation. 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