{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:18:06Z","timestamp":1784557086605,"version":"3.55.0"},"reference-count":37,"publisher":"Bioscientifica","issue":"4","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>\n                    It has been reported that ischemic preconditioning (IPC) and adiponectin (APN) are cardioprotective in many cardiovascular disorders. However, whether APN mediates the effect of IPC on myocardial injury has not been elucidated. This study was conducted to investigate whether IPC affects myocardial ischemic injury by increasing APN expression. Male adult rats with cardiac knockdowns of APN and its receptors via intramyocardial small-interfering RNA injection were subjected to IPC and then myocardial infarction (MI) at 24\u2009h after IPC. Globular APN (gAd) was injected at 10\u2009min before MI. APN mRNA and protein levels in myocardium as well as the plasma APN concentration were markedly high at 6 and 12\u2009h after IPC. IPC ameliorated myocardial injury as evidenced by improved cardiac functions and a reduced infarct size. Compared with the control MI group, rats in the IPC\u2009+\u2009MI group had elevated levels of left ventricular ejection fraction and fractional shortening and a smaller MI size (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). However, the aforementioned protective effects were ameliorated in the absence of APN and APN receptors, followed by the inhibition of AMP-activated protein kinase (AMPK) phosphorylation, but reversed by gAd treatment in wild-type rats, and AMPK phosphorylation increased (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Overall, our results suggest that the cardioprotective effects of IPC are partially due to upregulation of APN and provide a further insight into IPC-mediated signaling effects.\n                  <\/jats:p>","DOI":"10.1530\/jme-16-0163","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T20:30:24Z","timestamp":1487622624000},"page":"155-165","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":10,"title":["Cardioprotection of ischemic preconditioning in rats involves upregulating adiponectin"],"prefix":"10.1530","volume":"58","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"1Department of Intensive Care UnitChina-Japan Friendship Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Wu","sequence":"additional","affiliation":[{"name":"2Department of CardiologyChina-Japan Friendship 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