{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:21:46Z","timestamp":1792448506489,"version":"4.5.0"},"reference-count":48,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>\n                    Successful human embryo implantation requires a proper differentiation of endometrial stromal cells (ESCs) into decidual cells, during a process called decidualization. ESCs express specific molecules, such as prolactin, insulin-like growth factor-binding protein-1 (IGFBP-1) and connexin-43. Decidual cells are also involved in the control of trophoblast invasion, by secreting various factors, such as matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Adiponectin is an adipokine with insulin-sensitizing, anti-inflammatory and anti-proliferative effects. At the embryo\u2013maternal interface, adiponectin promotes differentiation and invasion of human trophoblastic cells. We hypothesize that the effects of adiponectin on endometrium could counteract its pro-invasive effects previously described in the human trophoblast. In this context, we have firstly demonstrated that adiponectin downregulates IGFBP-1 and connexin-43 mRNA expressions, as well as prolactin secretion in ESCs, suggesting an anti-differentiative effect of adiponectin. Secondly, we found that invasive capacities of trophoblastic cell line HTR-8\/SVneo are reduced in the presence of conditioned media from ESC cultured in the presence of adiponectin. Adiponectin\u2019s anti-invasive action is associated with a decreased activity of MMP-2 and MMP-9, and an increased\n                    <jats:italic>TIMP-3<\/jats:italic>\n                    mRNA expression in ESCs. Finally, adiponectin receptors (\n                    <jats:italic>ADIPOR1<\/jats:italic>\n                    and\n                    <jats:italic>ADIPOR2<\/jats:italic>\n                    ) knockdown abolishes the anti-differentiative and anti-invasive effects of adiponectin in human ESCs. Altogether, our results suggest that adiponectin reduces the decidualization process and inversely induces the production of endometrial factors that limit trophoblast invasion. Thus, through a dual control in trophoblast and endometrial cells, adiponectin appears as a pivotal actor of the embryo implantation process.\n                  <\/jats:p>","DOI":"10.1530\/jme-17-0046","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T20:30:21Z","timestamp":1500669021000},"page":"285-297","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":11,"title":["Adiponectin limits differentiation and trophoblast invasion in human endometrial cells"],"prefix":"10.1530","volume":"59","author":[{"given":"Fabien","family":"Duval","sequence":"first","affiliation":[{"name":"1GIG \u2013 EA 7404, Universit\u00e9 de Versailles-Saint-Quentin-en-Yvelines, Universit\u00e9 Paris-Saclay, Unit\u00e9 de Formation et de Recherche des Sciences de la Sant\u00e9 Simone Veil, Montigny-le-Bretonneux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Dos Santos","sequence":"additional","affiliation":[{"name":"1GIG \u2013 EA 7404, Universit\u00e9 de Versailles-Saint-Quentin-en-Yvelines, Universit\u00e9 Paris-Saclay, Unit\u00e9 de Formation et de Recherche des Sciences de la Sant\u00e9 Simone Veil, Montigny-le-Bretonneux, France"},{"name":"2Service de Biologie M\u00e9dicale, Centre Hospitalier de Poissy-Saint Germain, Poissy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadia","family":"Moindjie","sequence":"additional","affiliation":[{"name":"1GIG \u2013 EA 7404, Universit\u00e9 de Versailles-Saint-Quentin-en-Yvelines, Universit\u00e9 Paris-Saclay, Unit\u00e9 de Formation et de Recherche des Sciences de la Sant\u00e9 Simone Veil, Montigny-le-Bretonneux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Serazin","sequence":"additional","affiliation":[{"name":"1GIG \u2013 EA 7404, Universit\u00e9 de Versailles-Saint-Quentin-en-Yvelines, Universit\u00e9 Paris-Saclay, 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