{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:49:55Z","timestamp":1785455395663,"version":"3.56.0"},"reference-count":310,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n                    Insulin-like growth factor 1(IGF1) and ephrin ligand (EFN)\u2013receptor (EPH) signaling are both crucial for bone cell function and skeletal development and maintenance. IGF1 signaling is the major mediator of growth hormone-induced bone growth, but a host of different signals and factors regulate IGF1 signaling at the systemic and local levels. Disruption of the\n                    <jats:italic>Igf1<\/jats:italic>\n                    gene results in reduced peak bone mass in both experimental animal models and humans. Additionally, EFN\u2013EPH signaling is a complex system which, particularly through cell\u2013cell interactions, contributes to the development and differentiation of many bone cell types. Recent evidence has demonstrated several ways in which the IGF1 and EFN\u2013EPH signaling pathways interact with and depend upon each other to regulate bone cell function. While much remains to be elucidated, the interaction between these two signaling pathways opens a vast array of new opportunities for investigation into the mechanisms of and potential therapies for skeletal conditions such as osteoporosis and fracture repair.\n                  <\/jats:p>","DOI":"10.1530\/jme-17-0284","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T12:30:29Z","timestamp":1522067429000},"page":"T87-T102","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":23,"title":["40 YEARS OF IGF1: Role of IGF1 and EFN\u2013EPH signaling in skeletal metabolism"],"prefix":"10.1530","volume":"61","author":[{"given":"Richard C","family":"Lindsey","sequence":"first","affiliation":[{"name":"1Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California, USA"},{"name":"2Division of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA"},{"name":"3Center for Health Disparities and Molecular Medicine, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H","family":"Rundle","sequence":"additional","affiliation":[{"name":"1Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California, USA"},{"name":"4Department of Medicine, Loma Linda University, Loma Linda, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subburaman","family":"Mohan","sequence":"additional","affiliation":[{"name":"1Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California, USA"},{"name":"2Division of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA"},{"name":"3Center for Health Disparities and Molecular Medicine, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA"},{"name":"4Department of Medicine, Loma Linda University, Loma Linda, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref1971","first-page":"263","article-title":"Eph receptors and ephrin signaling pathways: a role in bone homeostasis","volume":"5","year":"2008","journal-title":"International Journal of Medical Sciences"},{"key":"ref1871","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.ajpath.2012.06.043","article-title":"Eph\/Ephrin signaling in injury and inflammation","volume":"181","year":"2012","journal-title":"American Journal of Pathology"},{"key":"ref761","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1210\/endo-125-3-1484","article-title":"Parathyroid hormone stimulates release of insulin-like growth factor-I (IGF-I) and IGF-II from neonatal mouse calvaria in organ culture.","volume":"125","year":"1989","journal-title":"Endocrinology"},{"key":"ref2891","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1210\/jc.2004-1314","article-title":"Testosterone and estradiol regulate free insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP-1), and dimeric IGF-I\/IGFBP-1 concentrations","volume":"90","year":"2005","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.ajpath.2012.06.043","article-title":"Eph\/Ephrin signaling in injury and inflammation","volume":"181","year":"2012","journal-title":"American Journal of Pathology"},{"key":"ref1221","doi-asserted-by":"crossref","first-page":"19378","DOI":"10.1073\/pnas.0809223105","article-title":"The hormonal action of IGF1 in postnatal mouse growth","volume":"105","year":"2008","journal-title":"PNAS"},{"key":"ref1521","doi-asserted-by":"crossref","first-page":"44005","DOI":"10.1074\/jbc.M208265200","article-title":"Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization","volume":"277","year":"2002b","journal-title":"Journal of Biological Chemistry"},{"key":"ref2801","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/jbmr.1820","article-title":"EphrinB2\/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone","volume":"28","year":"2013","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref3011","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1172\/JCI0215463","article-title":"Circulating levels of IGF-1 directly regulate bone growth and density","volume":"110","year":"2002","journal-title":"Journal of Clinical Investigation"},{"key":"ref2221","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/ajpendo.00440.2011","article-title":"KesavanCWergedalJELauK Conditional disruption of IGF gene in type \u03b1 collagen - expressing cells shows an essential role of IGF in skeletal anabolic response to loading of and https org","author":"HWMohanS","year":"2011","journal-title":"American Journal Physiology Endocrinology Metabolism"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"19937","DOI":"10.1074\/jbc.M109.014308","article-title":"Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism","volume":"284","year":"2009","journal-title":"Journal of Biological Chemistry"},{"key":"ref3001","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1073\/pnas.96.13.7324","article-title":"Normal growth and development in the absence of hepatic insulin-like growth factor I","volume":"96","year":"1999","journal-title":"PNAS"},{"key":"ref151","first-page":"61","article-title":"The Eph receptor\/ephrin system: an emerging player in the invasion game","volume":"10","year":"2008","journal-title":"Current Issues in Molecular Biology"},{"key":"ref2191","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1210\/endo.134.1.7506211","article-title":"Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases","volume":"134","year":"1994","journal-title":"Endocrinology"},{"key":"ref2541","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1210\/me.2011-0047","article-title":"Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH","volume":"25","year":"2011","journal-title":"Molecular Endocrinology"},{"key":"ref1001","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/jbmr.281","article-title":"Older men with low serum IGF-1 have an increased risk of incident fractures: the MrOS Sweden study","volume":"26","year":"2011","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref2151","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bone.2006.02.068","article-title":"Transgenic mice with osteoblast-targeted insulin-like growth factor-I show increased bone remodeling","volume":"39","year":"2006","journal-title":"Bone"},{"key":"ref1371","article-title":"IGF-I signaling in osterix-expressing cells regulates secondary ossification center formation, growth plate maturation, and metaphyseal formation during postnatal bone development","year":"2015","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref2001","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/j.1532-5415.2009.02285.x","article-title":"Increasing dietary protein requirements in elderly people for optimal muscle and bone health","volume":"57","year":"2009","journal-title":"Journal of the American Geriatrics Society"},{"key":"ref1431","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/jbmr.1551","article-title":"Genetic evidence that thyroid hormone is indispensable for prepubertal insulin-like growth factor-I expression and bone acquisition in mice","volume":"27","year":"2012","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref621","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yexcr.2016.08.017","article-title":"Eph receptor interclass cooperation is required for the regulation of cell proliferation","volume":"348","year":"2016","journal-title":"Experimental Cell Research"},{"key":"ref2591","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.1210\/en.2006-1055","article-title":"Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo","volume":"147","year":"2006","journal-title":"Endocrinology"},{"key":"ref1361","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1002\/jbmr.2196","article-title":"Ephrin B2\/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation","volume":"29","year":"2014","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref3101","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cmet.2006.05.012","article-title":"Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis","volume":"4","year":"2006","journal-title":"Cell Metabolism"},{"key":"ref2471","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1210\/endo.142.10.8436","article-title":"Evidence that anabolic effects of PTH on bone require IGF-I in growing mice","volume":"142","year":"2001a","journal-title":"Endocrinology"},{"key":"ref2511","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1152\/physrev.1999.79.2.511","article-title":"Neuroendocrine control of growth hormone secretion","volume":"79","year":"1999","journal-title":"Physiological Reviews"},{"key":"ref2811","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0047-6374(96)01793-9","article-title":"Mitogenic activity but not phenotype expression of rat osteoprogenitor cells in response to IGF-I is impaired in aged rats","volume":"92","year":"1996","journal-title":"Mechanisms of Ageing and Development"},{"key":"ref691","first-page":"549","article-title":"1,25-Dihydroxyvitamin D3 stimulates the production of insulin-like growth factor-binding proteins-2, -3 and -4 in human bone marrow stromal cells","volume":"144","year":"2001","journal-title":"European Journal of Endocrinology"},{"key":"ref2961","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4161\/19336918.2014.970007","article-title":"Regulation of cell differentiation by Eph receptor and ephrin signaling.","volume":"8","year":"2014","journal-title":"Cell Adhesion and Migration"},{"key":"ref701","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1172\/JCI87848","article-title":"Sinusoidal ephrin receptor EPHB4 controls hematopoietic progenitor cell mobilization from bone marrow","volume":"126","year":"2016","journal-title":"Journal of Clinical Investigation"},{"key":"ref781","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ghir.2015.12.004","article-title":"Does the GH\/IGF-1 axis contribute to skeletal sexual dimorphism? Evidence from mouse studies","volume":"27","year":"2016","journal-title":"Growth Hormone and IGF Research"},{"key":"ref2391","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S8756-3282(00)00408-7","article-title":"Influence of insulin-like growth factor-1 and leptin on bone mass in healthy postmenopausal women","volume":"28","year":"2001","journal-title":"Bone"},{"key":"ref1091","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/ajcn\/59.1.98","article-title":"Protein repletion and treatment in anorexia nervosa","volume":"59","year":"1994","journal-title":"American Journal of Clinical Nutrition"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1023\/B:AGEN.0000037340.33788.87","article-title":"Eph receptor tyrosine kinases in angiogenesis: from development to 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differentiation","volume":"48","year":"2011","journal-title":"Bone"},{"key":"ref2101","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/35041577","article-title":"Regulation of repulsion versus adhesion by different splice forms of an Eph receptor","volume":"408","year":"2000","journal-title":"Nature"},{"key":"ref1671","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1359\/jbmr.1999.14.12.2150","article-title":"Down-regulation of the serum stimulatory components of the insulin-like growth factor (IGF) system (IGF-I, IGF-II, IGF binding protein [BP]-3, and IGFBP-5) in age-related (type II) femoral neck osteoporosis","volume":"14","year":"1999","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref1311","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1530\/acta.0.1250538","article-title":"Insulin-like growth factor II and transforming growth factor beta 1 regulate insulin-like growth factor I secretion in mouse bone cells","volume":"125","year":"1991","journal-title":"Acta Endocrinologica"},{"key":"ref2981","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1128\/MCB.00610-09","article-title":"Ephrin B1 regulates bone marrow stromal cell differentiation and bone formation by influencing TAZ transactivation via complex formation with NHERF1","volume":"30","year":"2010","journal-title":"Molecular and Cellular Biology"},{"key":"ref971","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bone.2016.09.009","article-title":"Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development","volume":"93","year":"2016","journal-title":"Bone"},{"key":"ref1861","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1210\/edrv-14-1-20","article-title":"Human growth hormone and human aging","volume":"14","year":"1993","journal-title":"Endocrine Reviews"},{"key":"ref2361","first-page":"235060","article-title":"Effect of GH\/IGF-1 on bone metabolism and osteoporsosis.","volume":"2014","year":"2014","journal-title":"International Journal of Endocrinology"},{"key":"ref611","first-page":"3","article-title":"Insulin-like growth factors and their binding proteins: biological actions","volume":"16","year":"1995","journal-title":"Endocrine Reviews"},{"key":"ref1111","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1359\/JBMR.0301241","article-title":"Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways","volume":"19","year":"2004","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref1981","doi-asserted-by":"crossref","first-page":"19937","DOI":"10.1074\/jbc.M109.014308","article-title":"Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism","volume":"284","year":"2009","journal-title":"Journal of Biological Chemistry"},{"key":"ref2301","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1152\/ajpendo.1995.268.2.E318","article-title":"LeanJMJaggerCJChambersTJChowJW Increased insulin - like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation of https org","year":"1995","journal-title":"American Journal Physiology"},{"key":"ref771","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1210\/en.2013-2086","article-title":"Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles","volume":"155","year":"2014","journal-title":"Endocrinology"},{"key":"ref2661","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S8756-3282(03)00088-7","article-title":"Skeletal unloading induces resistance to insulin-like growth factor I on bone formation","volume":"32","year":"2003","journal-title":"Bone"},{"key":"ref2441","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1091\/mbc.e11-03-0183","article-title":"EphrinA\/EphA signal facilitates insulin-like growth factor-I-induced myogenic differentiation through suppression of the Ras\/extracellular signal-regulated kinase 1\/2 cascade in myoblast cell lines","volume":"22","year":"2011","journal-title":"Molecular Biology of the Cell"},{"key":"ref3091","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1210\/endo.141.7.7585","article-title":"Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation","volume":"141","year":"2000","journal-title":"Endocrinology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/jbmr.1821","article-title":"EphB4 enhances the process of endochondral ossification and inhibits remodeling during bone fracture repair","volume":"28","year":"2013","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref2071","doi-asserted-by":"crossref","first-page":"790","DOI":"10.7326\/0003-4819-133-10-200011210-00011","article-title":"Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa","volume":"133","year":"2000","journal-title":"Annals of Internal Medicine"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ydbio.2014.11.013","article-title":"Mechanisms of boundary formation by Eph receptor and ephrin signaling","volume":"401","year":"2015","journal-title":"Developmental Biology"},{"key":"ref2111","first-page":"1389","article-title":"Recombinant synthesis of insulin-like growth factor-binding protein-4 (IGFBP-4): development, validation, and application of a radioimmunoassay for IGFBP-4 in human serum and other biological fluids","volume":"81","year":"1996","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1083\/jcb.201104037","article-title":"Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors","volume":"195","year":"2011","journal-title":"Journal of Cell Biology"},{"key":"ref1101","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S8756-3282(03)00088-7","article-title":"Skeletal unloading induces resistance to insulin-like growth factor I on bone formation","volume":"32","year":"2003","journal-title":"Bone"},{"key":"ref1031","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.1210\/en.2006-1055","article-title":"Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo","volume":"147","year":"2006","journal-title":"Endocrinology"},{"key":"ref3051","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1210\/en.2004-1511","article-title":"Insulin receptor substrate-1 is required for bone anabolic function of parathyroid hormone in mice","volume":"146","year":"2005","journal-title":"Endocrinology"},{"key":"ref2771","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/jbmr.2084","article-title":"EphA4 receptor is a novel negative regulator of osteoclast activity","volume":"29","year":"2014","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref2841","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/jor.23767","article-title":"IGF-1 signaling mediated cell-specific skeletal mechano-transduction","volume":"36","year":"2018","journal-title":"Journal of Orthopaedic Research"},{"key":"ref751","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mce.2015.09.017","article-title":"Skeletal effects of growth hormone and insulin-like growth factor-I therapy.","volume":"432","year":"2016","journal-title":"Molecular and Cellular Endocrinology"},{"key":"ref1731","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ydbio.2014.11.013","article-title":"Mechanisms of boundary formation by Eph receptor and ephrin signaling","volume":"401","year":"2015","journal-title":"Developmental Biology"},{"key":"ref711","doi-asserted-by":"crossref","first-page":"R119","DOI":"10.1186\/ar2782","article-title":"Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes","volume":"11","year":"2009","journal-title":"Arthritis Research and Therapy"},{"key":"ref2041","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1210\/en.2007-0608","article-title":"Conditional deletion of insulin-like growth factor-I in collagen type 1alpha2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion","volume":"148","year":"2007a","journal-title":"Endocrinology"},{"key":"ref911","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1210\/endo.142.10.8436","article-title":"Evidence that anabolic effects of PTH on bone require IGF-I in growing mice","volume":"142","year":"2001a","journal-title":"Endocrinology"},{"key":"ref981","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1210\/me.2011-0047","article-title":"Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH","volume":"25","year":"2011","journal-title":"Molecular Endocrinology"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11914-005-0017-7","article-title":"Mechanisms of glucocorticoid action in bone.","volume":"3","year":"2005","journal-title":"Current Osteoporosis Reports"},{"key":"ref1771","doi-asserted-by":"crossref","first-page":"e32887","DOI":"10.1371\/journal.pone.0032887","article-title":"Targeted disruption of ephrin B1 in cells of myeloid lineage increases osteoclast differentiation and bone resorption in mice","volume":"7","year":"2012","journal-title":"PLoS ONE"},{"key":"ref1041","first-page":"801","article-title":"Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions","volume":"18","year":"1997","journal-title":"Endocrine Reviews"},{"key":"ref2411","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4161\/cam.20888","article-title":"Bone cell interactions through Eph\/ephrin: bone modeling, remodeling and associated diseases","volume":"6","year":"2012","journal-title":"Cell Adhesion and Migration"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1210\/en.2002-220129","article-title":"Transgenic mice overexpressing insulin-like growth factor binding protein-5 display transiently decreased osteoblastic function and osteopenia","volume":"143","year":"2002","journal-title":"Endocrinology"},{"key":"ref1151","doi-asserted-by":"crossref","first-page":"801","DOI":"10.7326\/0003-4819-128-10-199805150-00002","article-title":"Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial","volume":"128","year":"1998","journal-title":"Annals of Internal Medicine"},{"key":"ref1301","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1096\/fj.14-254300","article-title":"EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis","volume":"28","year":"2014","journal-title":"FASEB Journal"},{"key":"ref2091","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1210\/endo.138.10.5457","article-title":"Osteogenic protein-1 stimulates production of insulin-like growth factor binding protein-3 nuclear transcripts in human osteosarcoma cells","volume":"138","year":"1997","journal-title":"Endocrinology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1359\/jbmr.2000.15.4.683","article-title":"Protein undernutrition-induced bone loss is associated with decreased IGF-I levels and estrogen deficiency","volume":"15","year":"2000","journal-title":"Journal of Bone and 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rats","volume":"141","year":"2000","journal-title":"Endocrinology"},{"key":"ref1911","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1101\/gad.1171704","article-title":"Ephrin-B1 forward and reverse signaling are required during mouse development","volume":"18","year":"2004","journal-title":"Genes and Development"},{"key":"ref1271","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-59259-795-6_2","article-title":"Regulation of insulin-like growth factor-I by nutrition","volume-title":"IGF and Nutrition in Health and Disease","year":"2004"},{"key":"ref1381","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.yexcr.2017.02.021","article-title":"Mechanical stimulation promote the osteogenic differentiation of bone marrow stromal cells through epigenetic regulation of Sonic Hedgehog","volume":"352","year":"2017","journal-title":"Experimental Cell Research"},{"key":"ref1611","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/jbmr.5650090820","article-title":"Benefit of systemically administered rhIGF-I and rhIGF-I\/IGFBP-3 on cancellous bone in ovariectomized rats","volume":"9","year":"1994","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref2371","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00223-016-0152-4","article-title":"High serum insulin-like growth factor-binding protein 1 (IGFBP-1) is associated with high fracture risk independent of insulin-like growth factor 1 (IGF-I)","volume":"99","year":"2016","journal-title":"Calcified Tissue International"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1530\/eje.0.1340591","article-title":"Evidence for a role for insulin-like growth factor binding proteins in glucocorticoid inhibition of normal human osteoblast-like cell proliferation","volume":"134","year":"1996","journal-title":"European Journal of 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cascade in myoblast cell lines","volume":"22","year":"2011","journal-title":"Molecular Biology of the Cell"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1359\/jbmr.070907","article-title":"High-protein intake enhances the positive impact of physical activity on BMC in prepubertal boys","volume":"23","year":"2008","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref1571","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1359\/jbmr.2000.15.4.683","article-title":"Protein undernutrition-induced bone loss is associated with decreased IGF-I levels and estrogen deficiency","volume":"15","year":"2000","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref1801","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1530\/eje.0.1340591","article-title":"Evidence for a role for insulin-like growth factor binding proteins in glucocorticoid inhibition of normal human osteoblast-like cell 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3,5,3\u2019-triiodo-L-thyronine (T3) and their metabolites on osteoblast differentiation","volume":"99","year":"2016","journal-title":"Calcified Tissue International"},{"key":"ref741","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1152\/ajpendo.1995.268.2.E318","article-title":"LeanJMJaggerCJChambersTJChowJW Increased insulin - like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation of https org","year":"1995","journal-title":"American Journal Physiology"},{"key":"ref1511","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1006\/bbrc.2001.6217","article-title":"FGF-2 increases colony formation, PTH receptor, and IGF-1 mRNA in mouse marrow stromal cells","volume":"290","year":"2002a","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref2011","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF02678143","article-title":"Growth hormone secretion and sensitivity in men with idiopathic 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growth-hormone-stimulated serum levels of insulin-like growth factor (IGF)-I, IGF-II or IGF binding protein 3 in women with spinal osteoporosis","volume":"131","year":"1994","journal-title":"European Journal of Endocrinology"},{"key":"ref1621","first-page":"1484","article-title":"Circulating levels of insulin-like growth factor (IGF) binding protein-1 and -3 in aging men: relationships to insulin, glucose, IGF, and dehydroepiandrosterone sulfate levels and anthropometric measures","volume":"82","year":"1997","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref2241","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2353\/ajpath.2006.050889","article-title":"Receptor tyrosine kinase EphB4 is a survival factor in breast cancer","volume":"169","year":"2006","journal-title":"American Journal of Pathology"},{"key":"ref821","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1359\/jbmr.1997.12.3.423","article-title":"Insulin-like growth factor (IGF)-I, -II, IGF binding proteins (IGFBP)-3, -4, and -5 levels in the conditioned media of normal human bone cells are skeletal site-dependent","volume":"12","year":"1997","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref2381","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1359\/jbmr.1997.12.3.423","article-title":"Insulin-like growth factor (IGF)-I, -II, IGF binding proteins (IGFBP)-3, -4, and -5 levels in the conditioned media of normal human bone cells are skeletal site-dependent","volume":"12","year":"1997","journal-title":"Journal of Bone and Mineral Research"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.semcdb.2012.01.001","article-title":"Concepts and consequences of Eph receptor clustering.","volume":"23","year":"2012","journal-title":"Seminars in Cell and Developmental Biology"},{"key":"ref791","first-page":"1609","article-title":"17\u03b2-estradiol attenuates ovariectomy\u2011induced bone deterioration through the 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rats","volume":"141","year":"2000","journal-title":"Endocrinology"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1210\/endo-128-1-73","article-title":"Dexamethasone and 1,25-dihydroxyvitamin D3 modulation of insulin-like growth factor-binding proteins in rat osteoblast-like cell cultures","volume":"128","year":"1991","journal-title":"Endocrinology"},{"key":"ref1441","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1073\/pnas.96.13.7324","article-title":"Normal growth and development in the absence of hepatic insulin-like growth factor I","volume":"96","year":"1999","journal-title":"PNAS"},{"key":"ref2261","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1172\/JCI87848","article-title":"Sinusoidal ephrin receptor EPHB4 controls hematopoietic progenitor cell mobilization from bone marrow","volume":"126","year":"2016","journal-title":"Journal of Clinical 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A randomized, double-blind, placebo-controlled trial","volume":"128","year":"1998","journal-title":"Annals of Internal Medicine"},{"key":"ref2551","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.celrep.2015.09.085","article-title":"Ephrin-Bs drive junctional downregulation and actin stress fiber disassembly to enable wound re-epithelialization","volume":"13","year":"2015","journal-title":"Cell Reports"},{"key":"ref2571","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1083\/jcb.201604097","article-title":"Unidirectional Eph\/ephrin signaling creates a cortical actomyosin differential to drive cell segregation","volume":"215","year":"2016","journal-title":"Journal of Cell Biology"},{"key":"ref2331","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1210\/en.2013-2086","article-title":"Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine 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pathway","volume":"280","year":"2005","journal-title":"Journal of Biological Chemistry"},{"key":"ref2131","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1083\/jcb.201104037","article-title":"Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors","volume":"195","year":"2011","journal-title":"Journal of Cell Biology"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1101\/gad.13.23.3125","article-title":"Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion","volume":"13","year":"1999","journal-title":"Genes and Development"},{"key":"ref2671","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1359\/JBMR.0301241","article-title":"Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways","volume":"19","year":"2004","journal-title":"Journal of Bone and Mineral 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