{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:18:25Z","timestamp":1784557105264,"version":"3.55.0"},"reference-count":116,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>In mammals, the suprachiasmatic nucleus (SCN) is the location of a master circadian pacemaker. It receives photic signals from the environment via the retinal hypothalamic tract, which play a key role in synchronizing the body\u2019s endogenously generated circadian rhythms with the 24-h rhythm of the environment. Therefore, it is plausible that age-related changes within the SCN contribute to the etiology of perturbed activity\u2013rest cycles that become prevalent in humans during aging. To test this hypothesis, we used gene arrays and quantitative RT-PCR to profile age-related gene expression changes within the SCN of male rhesus macaques \u2013 a pragmatic translational animal model of human aging, which similarly displays an age-related attenuation of daytime activity levels. As expected, the SCN showed high expression of arginine vasopressin, vasoactive intestinal polypeptide, calbindin and nuclear receptor subfamily 1, group D, member 1 (NR1D1) (also known as reverse strand of ERBA (REV-ERB\u03b1), both at the mRNA and protein level. However, no obvious difference was detected between the SCNs of young (7\u201312 years) and old animals (21\u201326 years), in terms of the expression of core clock genes or genes associated with SCN signaling and neurotransmission. These data demonstrate the resilience of the primate SCN to normal aging, at least at the transcriptional level and, at least in males, suggest that age-related disruption of activity\u2013rest cycles in humans may instead stem from changes within other components of the circadian system, such as desynchronization of subordinate oscillators in other parts of the body.<\/jats:p>","DOI":"10.1530\/jme-18-0062","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T12:05:15Z","timestamp":1525867515000},"page":"57-67","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":13,"title":["Gene expression profiling of the SCN in young and old rhesus macaques"],"prefix":"10.1530","volume":"61","author":[{"given":"Dominique H","family":"Eghlidi","sequence":"first","affiliation":[{"name":"1Department of Neurology and Division of Sleep Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selva L","family":"Luna","sequence":"additional","affiliation":[{"name":"2Escuela de Qu\u00edmica y Farmacia, Facultad de Farmacia, Universidad de Valpara\u00edso, Valpara\u00edso, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald I","family":"Brown","sequence":"additional","affiliation":[{"name":"3Instituto de Biolog\u00eda, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilios T","family":"Garyfallou","sequence":"additional","affiliation":[{"name":"4Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G","family":"Kohama","sequence":"additional","affiliation":[{"name":"4Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henryk F","family":"Urbanski","sequence":"additional","affiliation":[{"name":"4Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA"},{"name":"5Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA"},{"name":"6Department of Physiology & Pharmacology, Oregon Health & Science University, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref321","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0304-3940(97)13355-9","article-title":"Loss of day-night differences in VIP mRNA levels in the suprachiasmatic nucleus of aged rats","volume":"222","year":"1997","journal-title":"Neuroscience Letters"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/cne.22761","article-title":"Neuron numbers in the hypothalamus of the normal aging rhesus 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