{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:42Z","timestamp":1787022822097,"version":"build-2736575974"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>\n                    Although progesterone has the ability to promote dilation of vascular smooth muscle, its role in coronary circulation is still poorly characterized, especially in essential hypertension and in a model of endogenous deficiency of ovarian hormones. Thus, this study evaluated the effect of progesterone treatment on endothelium-dependent coronary vascular reactivity in hypertensive (SHR) and ovariectomized rats. Adult SHR aged 8\u201310 weeks were divided into: SHAM, Ovariectomized (OVX) and Ovariectomized\u2009+\u2009treatment with 2 mg\/kg\/day of progesterone for 15 days (OVX-P4). Coronary vascular reactivity was investigated using the modified Langendorff method. After stabilization, baseline coronary perfusion pressure (CPP) was recorded and vascular reactivity to bradykinin (BK, 0.1\u20131000 ng) were assessed before and after infusion, either individually or in combination, with N\n                    <jats:sup>\u03c9<\/jats:sup>\n                    -nitro-\n                    <jats:sc>l<\/jats:sc>\n                    -arginine methyl ester (\n                    <jats:sc>l<\/jats:sc>\n                    -NAME), indomethacin or clotrimazole. Scanning electron microscopy was used for qualitative analysis of the endothelium. OVX and OVX-P4 groups had a higher baseline CPP compared to that of the SHAM group. BK was able to promote vasodilation in all groups. However, relaxation to BK was less pronounced in the OVX group when compared to SHAM, with architecture loss and areas of cell atrophy having been observed. Progesterone treatment prevented this injury. Perfusion with\n                    <jats:sc>l<\/jats:sc>\n                    -NAME induced greater damage to the SHAM group, while the use of indomethacin led to a significant reduction in the vasodilator response to BK in the OVX-P4 group. Taken together, our results show that progesterone modulates endothelium-dependent coronary vasodilation in SHR ovariectomized, preventing damage caused by ovarian hormonal deficiency through a mechanism that involves prostanoid pathway.\n                  <\/jats:p>","DOI":"10.1530\/jme-20-0187","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T11:34:39Z","timestamp":1610019279000},"page":"171-180","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":10,"title":["Progesterone modulates endothelium-dependent coronary vascular reactivity in SHR"],"prefix":"10.1530","volume":"66","author":[{"given":"D\u00e9bora Tacon","family":"da Costa","sequence":"first","affiliation":[{"name":"1Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, Espirito Santo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia Tinoco","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"1Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, Espirito Santo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssyca Aparecida Soares","family":"Giesen","sequence":"additional","affiliation":[{"name":"1Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, Espirito Santo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger Lyrio","family":"dos Santos","sequence":"additional","affiliation":[{"name":"1Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, Espirito Santo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Molecular Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/jme.bioscientifica.com\/view\/journals\/jme\/66\/2\/JME-20-0187.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jme.bioscientifica.com\/downloadpdf\/journals\/jme\/66\/2\/JME-20-0187.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:53:59Z","timestamp":1784555639000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/jme\/article\/66\/2\/171-180\/14482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/jme-20-0187","relation":{},"ISSN":["0952-5041","1479-6813"],"issn-type":[{"value":"0952-5041","type":"print"},{"value":"1479-6813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}