{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:36Z","timestamp":1784557236221,"version":"3.55.0"},"reference-count":89,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:p>\n                    Vitamin A (retinol) is an essential, fat-soluble vitamin that plays critical roles in embryonic development, vision, immunity, and reproduction. Severe vitamin A deficiency results in profound embryonic dysgenesis, blindness, and infertility. The roles of bioactive vitamin A metabolites in regulating cell proliferation, cellular differentiation, and immune cell function form the basis of their clinical use in the treatment of dermatologic conditions and hematologic malignancies. Increasingly, vitamin A also has been recognized to play important roles in cardiometabolic health, including the regulation of adipogenesis, energy partitioning, and lipoprotein metabolism. While these roles are strongly supported by animal and\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies, they remain poorly understood in human physiology and disease. This review briefly introduces vitamin A biology and presents the key preclinical data that have generated interest in vitamin A as a mediator of cardiometabolic health. The review also summarizes clinical studies performed to date, highlighting the limitations of many of these studies and the ongoing controversies in the field. Finally, additional perspectives are suggested that may help position vitamin A metabolism within a broader biological context and thereby contribute to enhanced understanding of vitamin A\u2019s complex roles in clinical cardiometabolic disease.\n                  <\/jats:p>","DOI":"10.1530\/jme-22-0078","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T06:40:03Z","timestamp":1658904003000},"page":"R95-R108","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":18,"title":["Vitamin A homeostasis and cardiometabolic disease in humans: lost in translation?"],"prefix":"10.1530","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4181-7522","authenticated-orcid":true,"given":"Aprajita S","family":"Yadav","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Isoherranen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6505-5657","authenticated-orcid":true,"given":"Katya B","family":"Rubinow","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA"},{"name":"Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"European Journal of Clinical Nutrition","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/sj.ejcn.1600825","article-title":"Retinol, alpha-tocopherol and carotenoids in diabetes","volume":"53","author":"Abahusain","year":"1999","unstructured":"Abahusain MAWright JDickerson JWde Vol EB1999Retinol, alpha-tocopherol and carotenoids in diabetes. 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