{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:18:58Z","timestamp":1784557138617,"version":"3.55.0"},"reference-count":53,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:p>\n                    Obesity affects thyroid gland function. Hypothyroidism, thyroid nodules, goiter, and thyroid cancer are more frequent in patients with higher BMI values. Although these data are supported by many clinical and epidemiological studies, our knowledge is very scarce at the molecular level. In this study, we present the first experimental evidence that adipocyte signaling downregulates the expression of thyroid-specific transcription factor 2 (TTF-2\/FoxE1). It plays a crucial role in thyroid development and thyroid homeostasis and it is strictly connected to thyroid cancer as well. We provide\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    evidence that inhibition of TTF-2\/FoxE1 gene expression is mediated by adipocyte signaling.\n                  <\/jats:p>","DOI":"10.1530\/jme-22-0129","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T17:49:22Z","timestamp":1667929762000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":0,"title":["Adipocyte signaling affects thyroid-specific gene expression via down-regulation of TTF-2\/FOXE1"],"prefix":"10.1530","volume":"70","author":[{"given":"Michela","family":"Zamboni","sequence":"first","affiliation":[{"name":"Institute of Biochemistry and Cell Biology, National Council of Research, Monterotondo, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Strimpakos","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology, National Council of Research, Monterotondo, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Poggiogalle","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine \u2013 Medical Pathophysiology, Food Science and Endocrinology Section, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo M","family":"Donini","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine \u2013 Medical Pathophysiology, Food Science and Endocrinology Section, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5719-9098","authenticated-orcid":true,"given":"Donato","family":"Civitareale","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology, National Council of Research, Monterotondo, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Metabolism: Clinical and Experimental","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.metabol.2018.11.001","article-title":"Obesity and cancer risk: emerging biological mechanisms and perspectives","volume":"92","author":"Avgerinos","year":"2019","unstructured":"Avgerinos KISpyrou NMantzoros CSDalamaga M2019Obesity and cancer risk: emerging biological mechanisms and perspectives. 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