{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:44:19Z","timestamp":1788925459366,"version":"build-2803163510"},"reference-count":115,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,12]]},"abstract":"<jats:p>Liver sinusoidal endothelial cells (LSECs) are highly specialised endothelial cells that form the liver microvasculature. LSECs maintain liver homeostasis, scavenging bloodborne molecules, regulating immune response, and actively promoting hepatic stellate cell quiescence. These diverse functions are underpinned by a suite of unique phenotypical attributes distinct from other blood vessels. In recent years, studies have begun to reveal the specific contributions of LSECs to liver metabolic homeostasis and how LSEC dysfunction associates with disease aetiology. This has been particularly evident in the context of non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, which is associated with the loss of key LSEC phenotypical characteristics and molecular identity. Comparative transcriptome studies of LSECs and other endothelial cells, together with rodent knockout models, have revealed that loss of LSEC identity through disruption of core transcription factor activity leads to impaired metabolic homeostasis and to hallmarks of liver disease. This review explores the current knowledge of LSEC transcription factors, covering their roles in LSEC development and maintenance of key phenotypic features, which, when disturbed, lead to loss of liver metabolic homeostasis and promote features of chronic liver diseases, such as non-alcoholic liver disease.<\/jats:p>","DOI":"10.1530\/jme-23-0026","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T10:43:05Z","timestamp":1686566585000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":10,"title":["RISING STARS: Liver sinusoidal endothelial transcription factors in metabolic homeostasis and disease"],"prefix":"10.1530","volume":"71","author":[{"given":"Dorka","family":"Nagy","sequence":"first","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK"},{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Maude","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme M","family":"Birdsey","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M","family":"Randi","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3528-4982","authenticated-orcid":true,"given":"In\u00eas","family":"Cebola","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Nature","first-page":"199","article-title":"A human liver cell atlas reveals heterogeneity and epithelial progenitors","volume":"572","author":"Aizarani","year":"2019","unstructured":"Aizarani NSaviano AMailly LDurand SHerman JSPessaux PBaumert TF & Gr\u00fcn D2019A human liver cell atlas reveals heterogeneity and epithelial progenitors. Nature572199\u2013204. (https:\/\/doi.org\/10.1038\/s41586-019-1373-2)"},{"key":"bib2","series-title":"Hepatology Communications","first-page":"821","article-title":"Single-cell, single-nucleus, and spatial RNA sequencing of the human liver identifies cholangiocyte and mesenchymal heterogeneity","volume":"6","author":"Andrews","year":"2022","unstructured":"Andrews TSAtif JLiu JCPerciani CTMa XZThoeni CSlyper MEraslan GSegerstolpe AManuel J, 2022Single-cell, single-nucleus, and spatial RNA sequencing of the human liver identifies cholangiocyte and mesenchymal heterogeneity. Hepatology Communications6821\u2013840. (https:\/\/doi.org\/10.1002\/hep4.1854)"},{"key":"bib3","series-title":"Journal of Hepatology","first-page":"505","article-title":"Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort","volume":"73","author":"Anstee","year":"2020","unstructured":"Anstee QMDarlay RCockell SMeroni MGovaere OTiniakos DBurt ADBedossa PPalmer JLiu YL, 2020Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort. Journal of Hepatology73505\u2013515. (https:\/\/doi.org\/10.1016\/j.jhep.2020.04.003)"},{"key":"bib4","series-title":"Hepatology","first-page":"983","article-title":"Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver","volume":"53","author":"Asahina","year":"2011","unstructured":"Asahina KZhou BPu WT & Tsukamoto H2011Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology53983\u2013995. (https:\/\/doi.org\/10.1002\/hep.24119)"},{"key":"bib5","series-title":"Nature Biotechnology","first-page":"825","article-title":"Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues","volume":"39","author":"Bartosovic","year":"2021","unstructured":"Bartosovic MKabbe M & Castelo-Branco G2021Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues. Nature Biotechnology39825\u2013835. (https:\/\/doi.org\/10.1038\/s41587-021-00869-9)"},{"key":"bib6","series-title":"Journal of Clinical Investigation","first-page":"209","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","unstructured":"Bataller R & Brenner DA2005Liver fibrosis. Journal of Clinical Investigation115209\u2013218. (https:\/\/doi.org\/10.1172\/JCI24282)"},{"key":"bib7","series-title":"Cell Reports","first-page":"1871","article-title":"Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells","volume":"9","author":"Batta","year":"2014","unstructured":"Batta KFlorkowska MKouskoff V & Lacaud G2014Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells. Cell Reports91871\u20131884. (https:\/\/doi.org\/10.1016\/j.celrep.2014.11.002)"},{"key":"bib8","series-title":"World Journal of Hepatology","first-page":"715","article-title":"Non-alcoholic fatty liver disease: an expanded review","volume":"9","author":"Benedict","year":"2017","unstructured":"Benedict M & Zhang X2017Non-alcoholic fatty liver disease: an expanded review. World Journal of Hepatology9715\u2013732. (https:\/\/doi.org\/10.4254\/wjh.v9.i16.715)"},{"key":"bib9","series-title":"Nature Reviews. Gastroenterology and Hepatology","first-page":"395","article-title":"Spatial heterogeneity in the mammalian liver","volume":"16","author":"Ben-Moshe","year":"2019","unstructured":"Ben-Moshe S & Itzkovitz S2019Spatial heterogeneity in the mammalian liver. Nature Reviews. Gastroenterology and Hepatology16395\u2013410. (https:\/\/doi.org\/10.1038\/s41575-019-0134-x)"},{"key":"bib10","series-title":"Developmental Cell","first-page":"82","article-title":"The endothelial transcription factor ERG promotes vascular stability and growth through Wnt\/\u03b2-catenin signaling","volume":"32","author":"Birdsey","year":"2015","unstructured":"Birdsey GMShah AVDufton NReynolds LEOsuna Almagro LYang YAspalter IMKhan STMason JCDejana E, 2015The endothelial transcription factor ERG promotes vascular stability and growth through Wnt\/\u03b2-catenin signaling. Developmental Cell3282\u201396. (https:\/\/doi.org\/10.1016\/j.devcel.2014.11.016)"},{"key":"bib11","series-title":"JHEP Reports","first-page":"100281","article-title":"A human liver chimeric mouse model for non-alcoholic fatty liver disease","volume":"3","author":"Bissig-Choisat","year":"2021","unstructured":"Bissig-Choisat BAlves-Bezerra MZorman BOchsner SABarzi MLegras XYang DBorowiak MDean AMYork RB, 2021A human liver chimeric mouse model for non-alcoholic fatty liver disease. JHEP Reports3100281. (https:\/\/doi.org\/10.1016\/j.jhepr.2021.100281)"},{"key":"bib12","series-title":"Journal of Cell Biology","first-page":"441","article-title":"Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study","volume":"72","author":"Blouin","year":"1977","unstructured":"Blouin ABolender RP & Weibel ER1977Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study. Journal of Cell Biology72441\u2013455. (https:\/\/doi.org\/10.1083\/jcb.72.2.441)"},{"key":"bib13","series-title":"Development","first-page":"4909","article-title":"GATA transcription factors as potentiators of gut endoderm differentiation","volume":"125","author":"Bossard","year":"1998","unstructured":"Bossard P & Zaret KS1998GATA transcription factors as potentiators of gut endoderm differentiation. Development1254909\u20134917. (https:\/\/doi.org\/10.1242\/dev.125.24.4909)"},{"key":"bib14","series-title":"Comparative Hepatology","article-title":"Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review","volume":"1","author":"Braet","year":"2002","unstructured":"Braet F & Wisse E2002Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review. Comparative Hepatology1 1. (https:\/\/doi.org\/10.1186\/1476-5926-1-1)"},{"key":"bib15","series-title":"Nature Communications","first-page":"4150","article-title":"Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control","volume":"9","author":"Brosch","year":"2018","unstructured":"Brosch MKattler KHerrmann AVon Sch\u00f6nfels WNordstr\u00f6m KSeehofer DDamm GBecker TZeissig SNehring S, 2018Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control. Nature Communications94150. (https:\/\/doi.org\/10.1038\/s41467-018-06611-5)"},{"key":"bib16","series-title":"Science","first-page":"612","article-title":"Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation","volume":"316","author":"Burgdorf","year":"2007","unstructured":"Burgdorf SKautz AB\u00f6hnert VKnolle PA & Kurts C2007Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science316612\u2013616. (https:\/\/doi.org\/10.1126\/science.1137971)"},{"key":"bib17","series-title":"Nucleic Acids Research","first-page":"4173","article-title":"Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals","volume":"25","author":"B\u00fcrglin","year":"1997","unstructured":"B\u00fcrglin TR1997Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals. Nucleic Acids Research254173\u20134180. (https:\/\/doi.org\/10.1093\/nar\/25.21.4173)"},{"key":"bib18","series-title":"Blood","first-page":"335","article-title":"Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation","volume":"120","author":"Cai","year":"2012","unstructured":"Cai MLanger EMGill JGSatpathy ATAlbring JCKc WMurphy TL & Murphy KM2012Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation. Blood120335\u2013346. (https:\/\/doi.org\/10.1182\/blood-2012-01-403139)"},{"key":"bib19","series-title":"Nucleic Acids Research","first-page":"D165","article-title":"JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles","volume":"50","author":"Castro-Mondragon","year":"2022","unstructured":"Castro-Mondragon JARiudavets-Puig RRauluseviciute IBerhanu Lemma RBTurchi LBlanc-Mathieu RLucas JBoddie PKhan AManosalva P\u00e9rez N, 2022JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles. Nucleic Acids Research50D165\u2013D173. (https:\/\/doi.org\/10.1093\/nar\/gkab1113)"},{"key":"bib20","series-title":"Wiley Interdisciplinary Reviews. Systems Biology and Medicine","article-title":"Liver gene regulatory networks: contributing factors to nonalcoholic fatty liver disease","volume":"12","author":"Cebola","year":"2020","unstructured":"Cebola I2020Liver gene regulatory networks: contributing factors to nonalcoholic fatty liver disease. Wiley Interdisciplinary Reviews. Systems Biology and Medicine12 e1480. (https:\/\/doi.org\/10.1002\/wsbm.1480)"},{"key":"bib21","series-title":"Journal of Hepatology","first-page":"829","article-title":"Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease","volume":"48","author":"Chalasani","year":"2008","unstructured":"Chalasani NWilson LKleiner DECummings OWBrunt EMUnalp A & NASH Clinical Research Network2008Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease. Journal of Hepatology48829\u2013834. (https:\/\/doi.org\/10.1016\/j.jhep.2008.01.016)"},{"key":"bib22","series-title":"Science","first-page":"910","article-title":"Multiplex single-cell profiling of chromatin accessibility by combinatorial cellular indexing","volume":"348","author":"Cusanovich","year":"2015","unstructured":"Cusanovich DADaza RAdey APliner HAChristiansen LGunderson KLSteemers FJTrapnell C & Shendure J2015Multiplex single-cell profiling of chromatin accessibility by combinatorial cellular indexing. Science348910\u2013914. (https:\/\/doi.org\/10.1126\/science.aab1601)"},{"key":"bib23","series-title":"Molecular Omics","first-page":"138","article-title":"Transcriptome profiling of hiPSC-derived LSECs with nanoCAGE","volume":"16","author":"Danoy","year":"2020","unstructured":"Danoy MPoulain SKoui YTauran YScheidecker BKido TMiyajima ASakai YPlessy C & Leclerc E2020Transcriptome profiling of hiPSC-derived LSECs with nanoCAGE. Molecular Omics16138\u2013146. (https:\/\/doi.org\/10.1039\/c9mo00135b)"},{"key":"bib24","series-title":"Circulation Research","first-page":"914","article-title":"Bone morphogenetic Protein-9 is a circulating vascular quiescence factor","volume":"102","author":"David","year":"2008","unstructured":"David LMallet CKeramidas MLamand\u00e9 NGasc JMDupuis-Girod SPlauchu HFeige JJ & Bailly S2008Bone morphogenetic Protein-9 is a circulating vascular quiescence factor. Circulation Research102914\u2013922. (https:\/\/doi.org\/10.1161\/CIRCRESAHA.107.165530)"},{"key":"bib26","series-title":"American Journal of Physiology: Gastrointestinal and Liver Physiology","first-page":"G803","article-title":"Unraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization","volume":"318","author":"de Haan","year":"2020","unstructured":"de Haan W\u00d8ie CBenkheil MDheedene WVinckier SCoppiello GAranguren XLBeerens MJaekers JTopal B, 2020Unraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization. American Journal of Physiology: Gastrointestinal and Liver Physiology318G803\u2013G815. (https:\/\/doi.org\/10.1152\/ajpgi.00215.2019)"},{"key":"bib25","series-title":"Cardiovascular Research","first-page":"1262","article-title":"Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis","volume":"118","author":"de Haan","year":"2022","unstructured":"de Haan WDheedene WApelt KD\u00e9combas-Deschamps SVinckier SVerhulst SConidi ADeffieux TStaring MWVandervoort P, 2022Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis. Cardiovascular Research1181262\u20131275. (https:\/\/doi.org\/10.1093\/cvr\/cvab148)"},{"key":"bib27","series-title":"Cell Death and Disease","article-title":"PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells","volume":"12","author":"De Smedt","year":"2021","unstructured":"De Smedt JVan Os EATalon IGhosh SToprakhisar BFurtado Madeiro Da Costa RZaunz SVazquez MABoon RBaatsen P, 2021PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells. Cell Death and Disease12 84. (https:\/\/doi.org\/10.1038\/s41419-020-03356-2)"},{"key":"bib28","series-title":"Journal of Clinical and Translational Hepatology","first-page":"53","article-title":"Animal models for fibrotic liver diseases: what we have, what we need, and what is under development","volume":"3","author":"Delire","year":"2015","unstructured":"Delire BSt\u00e4rkel P & Leclercq I2015Animal models for fibrotic liver diseases: what we have, what we need, and what is under development. Journal of Clinical and Translational Hepatology353\u201366. (https:\/\/doi.org\/10.14218\/JCTH.2014.00035)"},{"key":"bib29","series-title":"Hepatology","first-page":"1392","article-title":"Bone morphogenetic Protein 9 is a paracrine factor controlling liver sinusoidal endothelial cell fenestration and protecting against hepatic fibrosis","volume":"70","author":"Desroches-Castan","year":"2019","unstructured":"Desroches-Castan ATillet ERicard NOuarn\u00e9 MMallet CBelmudes LCout\u00e9 YBoillot OScoazec JYBailly S, 2019Bone morphogenetic Protein 9 is a paracrine factor controlling liver sinusoidal endothelial cell fenestration and protecting against hepatic fibrosis. Hepatology701392\u20131408. (https:\/\/doi.org\/10.1002\/hep.30655)"},{"key":"bib30","series-title":"Nature","first-page":"97","article-title":"Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis","volume":"505","author":"Ding","year":"2014","unstructured":"Ding BSCao ZLis RNolan DJGuo PSimons MPenfold MEShido KRabbany SY & Rafii S2014Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature50597\u2013102. (https:\/\/doi.org\/10.1038\/nature12681)"},{"key":"bib31","series-title":"Nature Communications","article-title":"Dynamic regulation of canonical TGF\u03b2 signalling by endothelial transcription factor ERG protects from liver fibrogenesis","volume":"8","author":"Dufton","year":"2017","unstructured":"Dufton NPPeghaire CROsuna-Almagro LRaimondi CKalna VChauhan AWebb GYang YBirdsey GMLalor P, 2017Dynamic regulation of canonical TGF\u03b2 signalling by endothelial transcription factor ERG protects from liver fibrogenesis. Nature Communications8 895. (https:\/\/doi.org\/10.1038\/s41467-017-01169-0)"},{"key":"bib32","series-title":"Hepatology","first-page":"865","article-title":"Long-term follow-up of patients with NAFLD and elevated liver enzymes","volume":"44","author":"Ekstedt","year":"2006","unstructured":"Ekstedt MFranz\u00e9n LEMathiesen ULThorelius LHolmqvist MBodemar G & Kechagias S2006Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology44865\u2013873. (https:\/\/doi.org\/10.1002\/hep.21327)"},{"key":"bib33","series-title":"Hepatology","first-page":"2007","article-title":"Liver sinusoidal endothelial cells depend on mannose receptor-mediated recruitment of lysosomal enzymes for normal degradation capacity","volume":"48","author":"Elvevold","year":"2008","unstructured":"Elvevold KSimon-Santamaria JHasvold HMccourt PSmedsr\u00f8d B & S\u00f8rensen KK2008Liver sinusoidal endothelial cells depend on mannose receptor-mediated recruitment of lysosomal enzymes for normal degradation capacity. Hepatology482007\u20132015. (https:\/\/doi.org\/10.1002\/hep.22527)"},{"key":"bib34","series-title":"Gastroenterology","article-title":"MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease","volume":"158","author":"Eslam","year":"2020","unstructured":"Eslam MSanyal AJ & George J2020MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease. Gastroenterology158 1999-2014.e1. (https:\/\/doi.org\/10.1053\/j.gastro.2019.11.312)"},{"key":"bib35","series-title":"Journal of Cellular Physiology","first-page":"14783","article-title":"The crucial role of ZEB2: from development to epithelial-to-mesenchymal transition and cancer complexity","volume":"234","author":"Fardi","year":"2019","unstructured":"Fardi MAlivand MBaradaran BFarshdousti Hagh M & Solali S2019The crucial role of ZEB2: from development to epithelial-to-mesenchymal transition and cancer complexity. Journal of Cellular Physiology23414783\u201314799. (https:\/\/doi.org\/10.1002\/jcp.28277)"},{"key":"bib36","series-title":"Hepatology","first-page":"1406","article-title":"Molecular pathophysiology of portal hypertension","volume":"61","author":"Fernandez","year":"2015","unstructured":"Fernandez M2015Molecular pathophysiology of portal hypertension. Hepatology611406\u20131415. (https:\/\/doi.org\/10.1002\/hep.27343)"},{"key":"bib37","series-title":"Trends in Pharmacological Sciences","first-page":"76","article-title":"Regulation of transcription factor activity by interconnected post-translational modifications","volume":"35","author":"Filtz","year":"2014","unstructured":"Filtz TMVogel WK & Leid M2014Regulation of transcription factor activity by interconnected post-translational modifications. Trends in Pharmacological Sciences3576\u201385. (https:\/\/doi.org\/10.1016\/j.tips.2013.11.005)"},{"key":"bib38","series-title":"Nature Medicine","first-page":"908","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","unstructured":"Friedman SLNeuschwander-Tetri BARinella M & Sanyal AJ2018Mechanisms of NAFLD development and therapeutic strategies. Nature Medicine24908\u2013922. (https:\/\/doi.org\/10.1038\/s41591-018-0104-9)"},{"key":"bib39","series-title":"Cell Stem Cell","first-page":"254","article-title":"Generation of functional liver sinusoidal endothelial cells from human pluripotent stem-cell-derived venous angioblasts","volume":"27","author":"Gage","year":"2020","unstructured":"Gage BKLiu JCInnes BTMacParland SAMcgilvray IDBader GD & Keller GM2020Generation of functional liver sinusoidal endothelial cells from human pluripotent stem-cell-derived venous angioblasts. Cell Stem Cell27254\u2013269.e9. (https:\/\/doi.org\/10.1016\/j.stem.2020.06.007)"},{"key":"bib40","series-title":"Journal of Immunology","first-page":"4981","article-title":"Fc\u03b3RIIb on liver sinusoidal endothelium clears small immune complexes","volume":"189","author":"Ganesan","year":"2012","unstructured":"Ganesan LPKim JWu YMohanty SPhillips GSBirmingham DJRobinson JM & Anderson CL2012Fc\u03b3RIIb on liver sinusoidal endothelium clears small immune complexes. Journal of Immunology1894981\u20134988. (https:\/\/doi.org\/10.4049\/jimmunol.1202017)"},{"key":"bib41","series-title":"Progress in Histochemistry and Cytochemistry","first-page":"201","article-title":"Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver","volume":"41","author":"Gebhardt","year":"2007","unstructured":"Gebhardt RBaldysiak-Figiel AKr\u00fcgel VUeberham E & Gaunitz F2007Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver. Progress in Histochemistry and Cytochemistry41201\u2013266. (https:\/\/doi.org\/10.1016\/j.proghi.2006.12.001)"},{"key":"bib43","series-title":"Hepatology","first-page":"313","article-title":"Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1","volume":"52","author":"G\u00e9raud","year":"2010","unstructured":"G\u00e9raud CSchledzewski KDemory AKlein DKaus MPeyre FSticht CEvdokimov KLu SSchmieder A, 2010Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1. Hepatology52313\u2013326. (https:\/\/doi.org\/10.1002\/hep.23618)"},{"key":"bib42","series-title":"Journal of Clinical Investigation","first-page":"1099","article-title":"GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis","volume":"127","author":"G\u00e9raud","year":"2017","unstructured":"G\u00e9raud CKoch PSZierow JKlapproth KBusch KOlsavszky VLeibing TDemory AUlbrich FDiett M, 2017GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. Journal of Clinical Investigation1271099\u20131114. (https:\/\/doi.org\/10.1172\/JCI90086)"},{"key":"bib44","series-title":"Cell","first-page":"559","article-title":"Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGF\u03b2 suppression","volume":"151","author":"Ginsberg","year":"2012","unstructured":"Ginsberg MJames DDing BSNolan DGeng FButler JMSchachterle WPulijaal VRMathew SChasen ST, 2012Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGF\u03b2 suppression. Cell151559\u2013575. (https:\/\/doi.org\/10.1016\/j.cell.2012.09.032)"},{"key":"bib45","series-title":"Nature Cardiovascular Research","first-page":"882","article-title":"Cooperative ETS transcription factors enforce adult endothelial cell fate and cardiovascular homeostasis","volume":"1","author":"G\u00f3mez-Salinero","year":"2022a","unstructured":"G\u00f3mez-Salinero JMItkin THoughton SBadwe CLin YKalna VDufton NPeghaire CRYokoyama MWingo M, 2022aCooperative ETS transcription factors enforce adult endothelial cell fate and cardiovascular homeostasis. Nature Cardiovascular Research1882\u2013899. (https:\/\/doi.org\/10.1038\/s44161-022-00128-3)"},{"key":"bib46","series-title":"Cell Stem Cell","article-title":"Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction","volume":"29","author":"G\u00f3mez-Salinero","year":"2022b","unstructured":"G\u00f3mez-Salinero JMIzzo FLin YHoughton SItkin TGeng FBram YAdelson RPLu TMInghirami G, 2022bSpecification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction. Cell Stem Cell29 593-609.e7. (https:\/\/doi.org\/10.1016\/j.stem.2022.03.002)"},{"key":"bib47","series-title":"Nature Cell Biology","first-page":"672","article-title":"ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage","volume":"24","author":"Gong","year":"2022","unstructured":"Gong WDas SSierra-Pagan JESkie EDsouza NLarson TAGarry MGLuzete-Monteiro EZaret KS & Garry DJ2022ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage. Nature Cell Biology24672\u2013684. (https:\/\/doi.org\/10.1038\/s41556-022-00901-3)"},{"key":"bib48","series-title":"Proceedings of the National Academy of Sciences of the United States of America","article-title":"Positional specificity of different transcription factor classes within enhancers","volume":"115","author":"Grossman","year":"2018","unstructured":"Grossman SREngreitz JRay JPNguyen THHacohen N & Lander ES2018Positional specificity of different transcription factor classes within enhancers. Proceedings of the National Academy of Sciences of the United States of America115 E7222\u2013E7230. (https:\/\/doi.org\/10.1073\/pnas.1804663115)"},{"key":"bib49","series-title":"Genes and Development","first-page":"1670","article-title":"Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control","volume":"10","author":"Gualdi","year":"1996","unstructured":"Gualdi RBossard PZheng MHamada YColeman JR & Zaret KS1996Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control. Genes and Development101670\u20131682. (https:\/\/doi.org\/10.1101\/gad.10.13.1670)"},{"key":"bib50","series-title":"Cell","first-page":"379","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"Guilliams","year":"2022","unstructured":"Guilliams MBonnardel JHaest BVanderborght BWagner CRemmerie ABujko AMartens LThon\u00e9 TBrowaeys R, 2022Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches. Cell185379\u2013396.e38. (https:\/\/doi.org\/10.1016\/j.cell.2021.12.018)"},{"key":"bib51","series-title":"Journal of Hepatology","first-page":"1278","article-title":"Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease","volume":"70","author":"Hammoutene","year":"2019","unstructured":"Hammoutene A & Rautou PE2019Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease. Journal of Hepatology701278\u20131291. (https:\/\/doi.org\/10.1016\/j.jhep.2019.02.012)"},{"key":"bib52","series-title":"Annual Review of Pathology: Mechanisms of Disease","first-page":"425","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","unstructured":"Hernandez-Gea V & Friedman SL2011Pathogenesis of liver fibrosis. Annual Review of Pathology: Mechanisms of Disease6425\u2013456. (https:\/\/doi.org\/10.1146\/annurev-pathol-011110-130246)"},{"key":"bib53","series-title":"Cell","first-page":"934","article-title":"Super-enhancers in the control of cell identity and disease","volume":"155","author":"Hnisz","year":"2013","unstructured":"Hnisz DAbraham BJLee TILau ASaint-Andr\u00e9 VSigova AAHoke HA & Young RA2013Super-enhancers in the control of cell identity and disease. Cell155934\u2013947. (https:\/\/doi.org\/10.1016\/j.cell.2013.09.053)"},{"key":"bib54","series-title":"Hepatology Communications","first-page":"161","article-title":"Transcriptomic cross-species analysis of chronic liver disease reveals consistent regulation between humans and mice","volume":"6","author":"Holland","year":"2022","unstructured":"Holland CHRamirez Flores ROMyllys MHassan REdlund KHofmann UMarchan RCadenas CReinders JHoehme S, 2022Transcriptomic cross-species analysis of chronic liver disease reveals consistent regulation between humans and mice. Hepatology Communications6161\u2013177. (https:\/\/doi.org\/10.1002\/hep4.1797)"},{"key":"bib55","series-title":"Science","first-page":"416","article-title":"Endothelial cell-derived angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat","volume":"343","author":"Hu","year":"2014","unstructured":"Hu JSrivastava KWieland MRunge AMogler CBesemfelder ETerhardt DVogel MJCao LKorn C, 2014Endothelial cell-derived angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. Science343416\u2013419. (https:\/\/doi.org\/10.1126\/science.1244880)"},{"key":"bib56","series-title":"Cell Reports. Medicine","article-title":"Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b","volume":"3","author":"Hu","year":"2022","unstructured":"Hu SLiu SBian YPoddar MSingh SCao CMcgaughey JBell ABlazer LLAdams JJ, 2022Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b. Cell Reports. Medicine3 100754. (https:\/\/doi.org\/10.1016\/j.xcrm.2022.100754)"},{"key":"bib57","series-title":"Hepatology","first-page":"1884","article-title":"A systematic review of animal models of NAFLD finds high-fat, high-fructose diets most closely resemble human NAFLD","volume":"74","author":"Im","year":"2021","unstructured":"Im YRHunter HDe Gracia Hahn DDuret ACheah QDong JFairey MHjalmarsson CLi ALim HK, 2021A systematic review of animal models of NAFLD finds high-fat, high-fructose diets most closely resemble human NAFLD. Hepatology741884\u20131901. (https:\/\/doi.org\/10.1002\/hep.31897)"},{"key":"bib58","series-title":"Frontiers in Immunology","first-page":"206","article-title":"c-MAF, a Swiss Army Knife for Tolerance in lymphocytes","volume":"11","author":"Imbratta","year":"2020","unstructured":"Imbratta CHussein HAndris F & Verdeil G2020c-MAF, a Swiss Army Knife for Tolerance in lymphocytes. Frontiers in Immunology11206. (https:\/\/doi.org\/10.3389\/fimmu.2020.00206)"},{"key":"bib59","series-title":"Developmental Cell","first-page":"1677","article-title":"A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie-Wnt signaling axis in the liver","volume":"56","author":"Inverso","year":"2021","unstructured":"Inverso DShi JLee KHJakab MBen-Moshe SKulkarni SRSchneider MWang GKomeili MV\u00e9lez PA, 2021A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie-Wnt signaling axis in the liver. Developmental Cell561677\u20131693.e10. (https:\/\/doi.org\/10.1016\/j.devcel.2021.05.001)"},{"key":"bib60","series-title":"Nature","first-page":"384","article-title":"DNA-dependent formation of transcription factor pairs alters their binding specificity","volume":"527","author":"Jolma","year":"2015","unstructured":"Jolma AYin YNitta KRDave KPopov ATaipale MEnge MKivioja TMorgunova E & Taipale J2015DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature527384\u2013388. (https:\/\/doi.org\/10.1038\/nature15518)"},{"key":"bib61","series-title":"Circulation Research","first-page":"1337","article-title":"The transcription factor ERG regulates super-enhancers associated with an endothelial-specific gene expression program","volume":"124","author":"Kalna","year":"2019","unstructured":"Kalna VYang YPeghaire CRFrudd KHannah RShah AVOsuna Almagro LBoyle JJG\u00f6ttgens BFerrer J, 2019The transcription factor ERG regulates super-enhancers associated with an endothelial-specific gene expression program. Circulation Research1241337\u20131349. (https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.313788)"},{"key":"bib62","series-title":"Frontiers in Physiology","article-title":"LSEC fenestrae are preserved despite pro-inflammatory phenotype of liver sinusoidal endothelial cells in mice on high fat diet","volume":"10","author":"Kus","year":"2019","unstructured":"Kus EKaczara PCzyzynska-Cichon ISzafranska KZapotoczny BKij ASowinska AKotlinowski JMateuszuk LCzarnowska E, 2019LSEC fenestrae are preserved despite pro-inflammatory phenotype of liver sinusoidal endothelial cells in mice on high fat diet. Frontiers in Physiology10 6. (https:\/\/doi.org\/10.3389\/fphys.2019.00006)"},{"key":"bib63","series-title":"Cells","article-title":"The endothelium as a driver of liver fibrosis and regeneration","volume":"9","author":"Lafoz","year":"2020","unstructured":"Lafoz ERuart MAnton AOncins A & Hern\u00e1ndez-Gea V2020The endothelium as a driver of liver fibrosis and regeneration. Cells9 929. (https:\/\/doi.org\/10.3390\/cells9040929)"},{"key":"bib64","series-title":"Cell","first-page":"650","article-title":"The human transcription factors","volume":"172","author":"Lambert","year":"2018","unstructured":"Lambert SAJolma ACampitelli LFDas PKYin YAlbu MChen XTaipale JHughes TR & Weirauch MT2018The human transcription factors. Cell172650\u2013665. (https:\/\/doi.org\/10.1016\/j.cell.2018.01.029)"},{"key":"bib65","series-title":"Hepatology","first-page":"707","article-title":"Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice","volume":"68","author":"Leibing","year":"2018","unstructured":"Leibing TG\u00e9raud CAugustin IBoutros MAugustin HGOkun JGLanghans CDZierow JWohlfeil SAOlsavszky V, 2018Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology68707\u2013722. (https:\/\/doi.org\/10.1002\/hep.29613)"},{"key":"bib66","series-title":"International Journal of Molecular Medicine","first-page":"1943","article-title":"Transcription factor PU.1 and immune cell differentiation (Review)","volume":"46","author":"Li","year":"2020","unstructured":"Li GHao W & Hu W2020Transcription factor PU.1 and immune cell differentiation (Review) (Review). International Journal of Molecular Medicine461943\u20131950. (https:\/\/doi.org\/10.3892\/ijmm.2020.4763)"},{"key":"bib67","series-title":"Developmental Cell","first-page":"398","article-title":"Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics","volume":"57","author":"Liang","year":"2022","unstructured":"Liang YKaneko KXin BLee JSun XZhang K & Feng GS2022Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics. Developmental Cell57398\u2013414.e5. (https:\/\/doi.org\/10.1016\/j.devcel.2022.01.004)"},{"key":"bib68","series-title":"Nature Medicine","first-page":"1348","article-title":"Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance","volume":"6","author":"Limmer","year":"2000","unstructured":"Limmer AOhl JKurts CLjunggren HGReiss YGroettrup MMomburg FArnold B & Knolle PA2000Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. Nature Medicine61348\u20131354. (https:\/\/doi.org\/10.1038\/82161)"},{"key":"bib69","series-title":"Nature Reviews. Molecular Cell Biology","first-page":"303","article-title":"Deep learning shapes single-cell data analysis","volume":"23","author":"Ma","year":"2022","unstructured":"Ma Q & Xu D2022Deep learning shapes single-cell data analysis. Nature Reviews. Molecular Cell Biology23303\u2013304. (https:\/\/doi.org\/10.1038\/s41580-022-00466-x)"},{"key":"bib70","series-title":"BMC Developmental Biology","article-title":"Meis2 is essential for cranial and cardiac neural crest development","volume":"15","author":"Machon","year":"2015","unstructured":"Machon OMasek JMachonova OKrauss S & Kozmik Z2015Meis2 is essential for cranial and cardiac neural crest development. BMC Developmental Biology15 40. (https:\/\/doi.org\/10.1186\/s12861-015-0093-6)"},{"key":"bib71","series-title":"Nature Communications","first-page":"4383","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"MacParland","year":"2018","unstructured":"MacParland SALiu JCMa X-ZInnes BTBartczak AMGage BKManuel JKhuu NEcheverri JLinares IGupta R, 2018Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations. Nature Communications94383. (https:\/\/doi.org\/10.1038\/s41467-018-06318-7)"},{"key":"bib72","series-title":"Cancers","article-title":"Transcriptomic profiling of the liver sinusoidal endothelium during cirrhosis reveals stage-specific secretory signature","volume":"13","author":"Manicardi","year":"2021","unstructured":"Manicardi NFern\u00e1ndez-Iglesias AAbad-Jord\u00e0 LRoyo FAzkargorta MOrtega-Ribera MSanfeliu-Redondo DMart\u00ednez-Alcocer AElortza FHessheimer AJ, 2021Transcriptomic profiling of the liver sinusoidal endothelium during cirrhosis reveals stage-specific secretory signature. Cancers13 2688. (https:\/\/doi.org\/10.3390\/cancers13112688)"},{"key":"bib73","series-title":"Science","first-page":"1190","article-title":"Systematic localization of common disease-associated variation in regulatory DNA","volume":"337","author":"Maurano","year":"2012","unstructured":"Maurano MTHumbert RRynes EThurman REHaugen EWang HReynolds APSandstrom RQu HBrody J, 2012Systematic localization of common disease-associated variation in regulatory DNA. Science3371190\u20131195. (https:\/\/doi.org\/10.1126\/science.1222794)"},{"key":"bib74","series-title":"Laboratory Investigation","first-page":"1130","article-title":"Pivotal role of liver sinusoidal endothelial cells in NAFLD\/NASH progression","volume":"95","author":"Miyao","year":"2015","unstructured":"Miyao MKotani HIshida TKawai CManabe SAbiru H & Tamaki K2015Pivotal role of liver sinusoidal endothelial cells in NAFLD\/NASH progression. Laboratory Investigation951130\u20131144. (https:\/\/doi.org\/10.1038\/labinvest.2015.95)"},{"key":"bib75","series-title":"Developmental Biology","first-page":"193","article-title":"Hox cofactors in vertebrate development","volume":"291","author":"Moens","year":"2006","unstructured":"Moens CB & Selleri L2006Hox cofactors in vertebrate development. Developmental Biology291193\u2013206. (https:\/\/doi.org\/10.1016\/j.ydbio.2005.10.032)"},{"key":"bib76","series-title":"Proceedings of the National Academy of Sciences of the United States of America","first-page":"160","article-title":"ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells","volume":"112","author":"Morita","year":"2015","unstructured":"Morita RSuzuki MKasahara HShimizu NShichita TSekiya TKimura ASasaki KYasukawa H & Yoshimura A2015ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells. Proceedings of the National Academy of Sciences of the United States of America112160\u2013165. (https:\/\/doi.org\/10.1073\/pnas.1413234112)"},{"key":"bib77","series-title":"BMC Medicine","article-title":"GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network","volume":"17","author":"Namjou","year":"2019","unstructured":"Namjou BLingren THuang YParameswaran SCobb BLStanaway IBConnolly JJMentch FDBenoit BNiu X, 2019GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network. BMC Medicine17 135. (https:\/\/doi.org\/10.1186\/s12916-019-1364-z)"},{"key":"bib78","series-title":"Genome Biology","article-title":"Mechanisms of enhancer action: the known and the unknown","volume":"22","author":"Panigrahi","year":"2021","unstructured":"Panigrahi A & O\u2019Malley BW2021Mechanisms of enhancer action: the known and the unknown. Genome Biology22 108. (https:\/\/doi.org\/10.1186\/s13059-021-02322-1)"},{"key":"bib79","series-title":"Hepatology","first-page":"1219","article-title":"Liver zonation, revisited","volume":"76","author":"Paris","year":"2022","unstructured":"Paris J & Henderson NC2022Liver zonation, revisited. Hepatology761219\u20131230. (https:\/\/doi.org\/10.1002\/hep.32408)"},{"key":"bib80","series-title":"Journal of Experimental Medicine","article-title":"c-Maf regulates the plasticity of group 3 innate lymphoid cells by restraining the type 1 program","volume":"217","author":"Parker","year":"2020","unstructured":"Parker MEBarrera AWheaton JDZuberbuehler MKAllan DSJCarlyle JRReddy TE & Ciofani M2020c-Maf regulates the plasticity of group 3 innate lymphoid cells by restraining the type 1 program. Journal of Experimental Medicine217. (https:\/\/doi.org\/10.1084\/jem.20191030)"},{"key":"bib81","series-title":"Nature Communications","article-title":"The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature","volume":"10","author":"Peghaire","year":"2019","unstructured":"Peghaire CDufton NPLang MSalles-Crawley IIAhnstr\u00f6m JKalna VRaimondi CPericleous CInuabasi LKiseleva R, 2019The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature. Nature Communications10 5014. (https:\/\/doi.org\/10.1038\/s41467-019-12897-w)"},{"key":"bib82","series-title":"Nucleic Acids Research","first-page":"6391","article-title":"Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1","volume":"41","author":"Pham","year":"2013","unstructured":"Pham THMinderjahn JSchmidl CHoffmeister HSchmidhofer SChen WL\u00e4ngst GBenner C & Rehli M2013Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1. Nucleic Acids Research416391\u20136402. (https:\/\/doi.org\/10.1093\/nar\/gkt355)"},{"key":"bib83","series-title":"Journal of Hepatology","first-page":"212","article-title":"Liver sinusoidal endothelial cells: physiology and role in liver diseases","volume":"66","author":"Poisson","year":"2017","unstructured":"Poisson JLemoinne SBoulanger CDurand FMoreau RValla D & Rautou PE2017Liver sinusoidal endothelial cells: physiology and role in liver diseases. Journal of Hepatology66212\u2013227. (https:\/\/doi.org\/10.1016\/j.jhep.2016.07.009)"},{"key":"bib84","series-title":"EMBO Journal","first-page":"2453","article-title":"Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins","volume":"22","author":"Postigo","year":"2003","unstructured":"Postigo AADepp JLTaylor JJ & Kroll KL2003Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO Journal222453\u20132462. (https:\/\/doi.org\/10.1093\/emboj\/cdg226)"},{"key":"bib85","series-title":"Hepatology Communications","first-page":"845","article-title":"Endothelial Wnts regulate \u03b2-catenin signaling in murine liver zonation and regeneration: a sequel to the Wnt\u2013Wnt situation","volume":"2","author":"Preziosi","year":"2018","unstructured":"Preziosi MOkabe HPoddar MSingh S & Monga SP2018Endothelial Wnts regulate \u03b2-catenin signaling in murine liver zonation and regeneration: a sequel to the Wnt\u2013Wnt situation. Hepatology Communications2845\u2013860. (https:\/\/doi.org\/10.1002\/hep4.1196)"},{"key":"bib86","series-title":"Nature","first-page":"512","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","unstructured":"Ramachandran PDobie RWilson-Kanamori JRDora EFHenderson BEPLuu NTPortman JRMatchett KPBrice MMarwick JA, 2019Resolving the fibrotic niche of human liver cirrhosis at single-cell level. Nature575512\u2013518. (https:\/\/doi.org\/10.1038\/s41586-019-1631-3)"},{"key":"bib87","series-title":"Cellular and Molecular Gastroenterology and Hepatology","first-page":"1135","article-title":"Modeling non-alcoholic fatty liver disease in the dish using human-specific platforms \u2013 strategies and limitations","volume":"15","author":"Rezvani","year":"2023","unstructured":"Rezvani MVallier L & Guillot A2023Modeling non-alcoholic fatty liver disease in the dish using human-specific platforms \u2013 strategies and limitations. Cellular and Molecular Gastroenterology and Hepatology151135\u20131145. (https:\/\/doi.org\/10.1016\/j.jcmgh.2023.01.014)"},{"key":"bib88","series-title":"Frontiers in Cell and Developmental Biology","article-title":"Capillarized liver sinusoidal endothelial cells undergo partial endothelial-mesenchymal transition to actively deposit sinusoidal ECM in liver fibrosis","volume":"9","author":"Ruan","year":"2021","unstructured":"Ruan BDuan JLXu HTao KSHan HDou GR & Wang L2021Capillarized liver sinusoidal endothelial cells undergo partial endothelial-mesenchymal transition to actively deposit sinusoidal ECM in liver fibrosis. Frontiers in Cell and Developmental Biology9 671081. (https:\/\/doi.org\/10.3389\/fcell.2021.671081)"},{"key":"bib89","series-title":"Journal of Hepatology","first-page":"1219","article-title":"Single-cell genomics and spatial transcriptomics: discovery of novel cell states and cellular interactions in liver physiology and disease biology","volume":"73","author":"Saviano","year":"2020","unstructured":"Saviano AHenderson NC & Baumert TF2020Single-cell genomics and spatial transcriptomics: discovery of novel cell states and cellular interactions in liver physiology and disease biology. Journal of Hepatology731219\u20131230. (https:\/\/doi.org\/10.1016\/j.jhep.2020.06.004)"},{"key":"bib90","series-title":"Journal of Clinical Investigation","first-page":"703","article-title":"Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors","volume":"121","author":"Schledzewski","year":"2011","unstructured":"Schledzewski KG\u00e9raud CArnold BWang SGr\u00f6ne HJKempf TWollert KCStraub BKSchirmacher PDemory A, 2011Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. Journal of Clinical Investigation121703\u2013714. (https:\/\/doi.org\/10.1172\/JCI44740)"},{"key":"bib92","series-title":"Journal of Clinical Investigation","first-page":"2923","article-title":"Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids","volume":"100","author":"Shah","year":"1997","unstructured":"Shah VHaddad FGGarcia-Cardena GFrangos JAMennone AGroszmann RJ & Sessa WC1997Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. Journal of Clinical Investigation1002923\u20132930. (https:\/\/doi.org\/10.1172\/JCI119842)"},{"key":"bib91","series-title":"Vascular Pharmacology","first-page":"3","article-title":"Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG","volume":"86","author":"Shah","year":"2016","unstructured":"Shah AVBirdsey GM & Randi AM2016Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG. Vascular Pharmacology863\u201313. (https:\/\/doi.org\/10.1016\/j.vph.2016.05.003)"},{"key":"bib93","series-title":"Clinical Gastroenterology and Hepatology","article-title":"Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies","volume":"13","author":"Singh","year":"2015","unstructured":"Singh SAllen AMWang ZProkop LJMurad MH & Loomba R2015Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clinical Gastroenterology and Hepatology13 643\u201354.e1.e1-9. (https:\/\/doi.org\/10.1016\/j.cgh.2014.04.014)"},{"key":"bib94","series-title":"American Journal of Clinical Nutrition","first-page":"422","article-title":"Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level","volume":"103","author":"Sookoian","year":"2016","unstructured":"Sookoian SCasta\u00f1o GOScian RFern\u00e1ndez Gianotti TDopazo HRohr CGaj GSan Martino JSevic IFlichman D, 2016Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level. American Journal of Clinical Nutrition103422\u2013434. (https:\/\/doi.org\/10.3945\/ajcn.115.118695)"},{"key":"bib95","series-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology","first-page":"R1217","article-title":"The scavenger endothelial cell: a new player in homeostasis and immunity","volume":"303","author":"S\u00f8rensen","year":"2012","unstructured":"S\u00f8rensen KKMccourt PBerg TCrossley CCouteur DLWake K & Smedsr\u00f8d B2012The scavenger endothelial cell: a new player in homeostasis and immunity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology303R1217\u2013R1230. (https:\/\/doi.org\/10.1152\/ajpregu.00686.2011)"},{"key":"bib96","series-title":"Comprehensive Physiology","first-page":"1751","article-title":"Liver sinusoidal endothelial cells","volume":"5","author":"S\u00f8rensen","year":"2015","unstructured":"S\u00f8rensen KKSimon-Santamaria JMccuskey RS & Smedsr\u00f8d B2015Liver sinusoidal endothelial cells. Comprehensive Physiology51751\u20131774. (https:\/\/doi.org\/10.1002\/cphy.c140078)"},{"key":"bib97","series-title":"Metabolites","article-title":"Transcriptional regulation in non-alcoholic fatty liver disease","volume":"10","author":"Steensels","year":"2020","unstructured":"Steensels SQiao J & Ersoy BA2020Transcriptional regulation in non-alcoholic fatty liver disease. Metabolites10. (https:\/\/doi.org\/10.3390\/metabo10070283)"},{"key":"bib98","series-title":"Liver International","first-page":"2534","article-title":"Zonation in NASH \u2013 A key paradigm for understanding pathophysiology and clinical outcomes","volume":"41","author":"Steinman","year":"2021","unstructured":"Steinman JBSalomao MA & Pajvani UB2021Zonation in NASH \u2013 A key paradigm for understanding pathophysiology and clinical outcomes. Liver International412534\u20132546. (https:\/\/doi.org\/10.1111\/liv.15025)"},{"key":"bib99","series-title":"Scientific Reports","article-title":"Immunofluorescence identifies distinct subsets of endothelial cells in the human liver","volume":"7","author":"Strauss","year":"2017","unstructured":"Strauss OPhillips ARuggiero KBartlett A & Dunbar PR2017Immunofluorescence identifies distinct subsets of endothelial cells in the human liver. Scientific Reports7 44356. (https:\/\/doi.org\/10.1038\/srep44356)"},{"key":"bib100","series-title":"Cellular and Molecular Gastroenterology and Hepatology","first-page":"1139","article-title":"Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis","volume":"11","author":"Su","year":"2021","unstructured":"Su TYang YLai SJeong JJung YMcconnell MUtsumi T & Iwakiri Y2021Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis. Cellular and Molecular Gastroenterology and Hepatology111139\u20131161. (https:\/\/doi.org\/10.1016\/j.jcmgh.2020.12.007)"},{"key":"bib101","series-title":"World Journal of Gastroenterology","first-page":"15539","article-title":"Histopathology of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"20","author":"Takahashi","year":"2014","unstructured":"Takahashi Y & Fukusato T2014Histopathology of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis. World Journal of Gastroenterology2015539\u201315548. (https:\/\/doi.org\/10.3748\/wjg.v20.i42.15539)"},{"key":"bib102","series-title":"Development","article-title":"GATA transcription factors in development and disease","volume":"145","author":"Tremblay","year":"2018","unstructured":"Tremblay MSanchez-Ferras O & Bouchard M2018GATA transcription factors in development and disease. Development145. (https:\/\/doi.org\/10.1242\/dev.164384)"},{"key":"bib103","series-title":"Journal of Hepatology","first-page":"385","article-title":"A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer","volume":"69","author":"Tsuchida","year":"2018","unstructured":"Tsuchida TLee YAFujiwara NYbanez MAllen BMartins SFiel MIGoossens NChou HIHoshida Y, 2018A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer. Journal of Hepatology69385\u2013395. (https:\/\/doi.org\/10.1016\/j.jhep.2018.03.011)"},{"key":"bib104","series-title":"Development","first-page":"3973","article-title":"Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis","volume":"139","author":"Vijayaraj","year":"2012","unstructured":"Vijayaraj PLe Bras AMitchell NKondo MJuliao SWasserman MBeeler DSpokes KAird WCBaldwin HS, 2012Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis. Development1393973\u20133985. (https:\/\/doi.org\/10.1242\/dev.081596)"},{"key":"bib105","series-title":"Mechanisms of Development","first-page":"331","article-title":"The Ets family member Erg gene is expressed in mesodermal tissues and neural crests at fundamental steps during mouse embryogenesis","volume":"91","author":"Vlaeminck-Guillem","year":"2000","unstructured":"Vlaeminck-Guillem VCarrere SDewitte FStehelin DDesbiens X & Duterque-Coquillaud M2000The Ets family member Erg gene is expressed in mesodermal tissues and neural crests at fundamental steps during mouse embryogenesis. Mechanisms of Development91331\u2013335. (https:\/\/doi.org\/10.1016\/s0925-4773(9900272-5)"},{"key":"bib106","series-title":"BMC Developmental Biology","article-title":"Development of the mammalian liver and ventral pancreas is dependent on GATA4","volume":"7","author":"Watt","year":"2007","unstructured":"Watt AJZhao RLi J & Duncan SA2007Development of the mammalian liver and ventral pancreas is dependent on GATA4. BMC Developmental Biology7 37. (https:\/\/doi.org\/10.1186\/1471-213X-7-37)"},{"key":"bib107","series-title":"Cell Systems","first-page":"319","article-title":"Mammalian transcription factor networks: recent advances in interrogating biological complexity","volume":"5","author":"Wilkinson","year":"2017","unstructured":"Wilkinson ACNakauchi H & G\u00f6ttgens B2017Mammalian transcription factor networks: recent advances in interrogating biological complexity. Cell Systems5319\u2013331. (https:\/\/doi.org\/10.1016\/j.cels.2017.07.004)"},{"key":"bib108","series-title":"Journal of Hepatology","first-page":"380","article-title":"Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling","volume":"74","author":"Winkler","year":"2021","unstructured":"Winkler MStaniczek TK\u00fcrschner SWSchmid CDSch\u00f6nhaber HCordero JKessler LMathes ASticht CNesslin M, 2021Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. Journal of Hepatology74380\u2013393. (https:\/\/doi.org\/10.1016\/j.jhep.2020.08.033)"},{"key":"bib109","series-title":"Journal of Ultrastructure Research","first-page":"125","article-title":"An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids","volume":"31","author":"Wisse","year":"1970","unstructured":"Wisse E1970An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids. Journal of Ultrastructure Research31125\u2013150. (https:\/\/doi.org\/10.1016\/s0022-5320(7090150-4)"},{"key":"bib110","series-title":"Molecular Cell","first-page":"644","article-title":"Landscape of intercellular crosstalk in healthy and NASH liver revealed by single-cell secretome gene analysis","volume":"75","author":"Xiong","year":"2019","unstructured":"Xiong XKuang HAnsari SLiu TGong JWang SZhao XYJi YLi CGuo L, 2019Landscape of intercellular crosstalk in healthy and NASH liver revealed by single-cell secretome gene analysis. Molecular Cell75644\u2013660.e5. (https:\/\/doi.org\/10.1016\/j.molcel.2019.07.028)"},{"key":"bib111","series-title":"Nature Reviews. Gastroenterology and Hepatology","first-page":"11","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","unstructured":"Younossi ZAnstee QMMarietti MHardy THenry LEslam MGeorge J & Bugianesi E2018Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nature Reviews. Gastroenterology and Hepatology1511\u201320. (https:\/\/doi.org\/10.1038\/nrgastro.2017.109)"},{"key":"bib112","series-title":"Hepatology","first-page":"1335","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"77","author":"Younossi","year":"2023","unstructured":"Younossi ZMGolabi PPaik JMHenry AVan Dongen C & Henry L2023The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review. Hepatology771335\u20131347. (https:\/\/doi.org\/10.1097\/HEP.0000000000000004)"},{"key":"bib113","series-title":"Nucleic Acids Research","first-page":"84","article-title":"Estimating binding properties of transcription factors from genome-wide binding profiles","volume":"43","author":"Zabet","year":"2015","unstructured":"Zabet NR & Adryan B2015Estimating binding properties of transcription factors from genome-wide binding profiles. Nucleic Acids Research4384\u201394. (https:\/\/doi.org\/10.1093\/nar\/gku1269)"},{"key":"bib114","series-title":"Annual Review of Genetics","first-page":"367","article-title":"Pioneer transcription factors initiating gene network changes","volume":"54","author":"Zaret","year":"2020","unstructured":"Zaret KS2020Pioneer transcription factors initiating gene network changes. Annual Review of Genetics54367\u2013385. (https:\/\/doi.org\/10.1146\/annurev-genet-030220-015007)"},{"key":"bib115","series-title":"Nature Structural and Molecular Biology","first-page":"1148","article-title":"Current challenges in understanding the role of enhancers in disease","volume":"29","author":"Zaugg","year":"2022","unstructured":"Zaugg JBSahl\u00e9n PAndersson RAlberich-Jorda MDe Laat WDeplancke BFerrer JMandrup SNatoli GPlewczynski D, 2022Current challenges in understanding the role of enhancers in disease. Nature Structural and Molecular Biology291148\u20131158. 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