{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:39:40Z","timestamp":1785281980732,"version":"3.55.0"},"reference-count":48,"publisher":"Bioscientifica","issue":"4","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9,5]]},"abstract":"<jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                    <jats:p>\n                      <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"images\/JME-23-0039inf1.jpeg\"\/>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Uterine fibroids (UFs) are benign tumors arising from the uterus, characterized by accumulation of abundant extracellular matrix (ECM) and sex steroid-dependent growth. Women with symptomatic UFs have reduced quality of life and decreased labor productivity. Among the driver gene mutations identified in UFs, mutations in MED12, a component of the cyclin-dependent kinase (CDK) Mediator module, are the most common and observed in 50\u201380% of UFs. They are gain-of-function mutations and are more frequently observed in Black women and commonly observed even in small UFs. MED12 mutation-positive UFs (MED12-UFs) often develop multiple rather than solitary and have distinct gene expression profiles, DNA methylomes, transcriptomes, and proteomes. Gene expressions related to ECM organization and collagen-rich ECM components are upregulated, and impaired Mediator kinase activity and dysregulation of Wnt\/\u03b2-catenin signaling are identified in MED12-UFs. Clinically, the UF shrinking effect of gonadotropin-releasing hormone agonists and ulipristal acetate is dependent on the MED12 mutation status. Understanding of characteristics of MED12-UFs and functions of MED12 mutations for UF tumorigenesis may elucidate the pathophysiology of UFs, leading to the development of new therapeutic options in women with symptomatic UFs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/jme-23-0039","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T08:48:20Z","timestamp":1693903700000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":15,"title":["RISING STARS: Role of MED12 mutation in the pathogenesis of uterine fibroids"],"prefix":"10.1530","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1116-6885","authenticated-orcid":true,"given":"Hiroshi","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5072-6756","authenticated-orcid":true,"given":"Tatsuya","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan"},{"name":"Evolution and Reproductive Medicine, Medical Mycology Research Center, Chiba University, Chiba, Japan"},{"name":"Fujita Medical Innovation Center Tokyo, Reproduction Center, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meika","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2760-6729","authenticated-orcid":true,"given":"Yoshiko","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7247-2205","authenticated-orcid":true,"given":"Makio","family":"Shozu","sequence":"additional","affiliation":[{"name":"Evolution and Reproductive Medicine, Medical Mycology Research Center, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-4120","authenticated-orcid":true,"given":"Kaori","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib48","series-title":"Endocrinology","first-page":"592","article-title":"Silencing Med12 gene reduces proliferation of human leiomyoma cells mediated via Wnt\/\u03b2-catenin signaling pathway","year":"2017","unstructured":"Al-Hendy ALaknaur ADiamond MPIsmail NBoyer TG & Halder SK2017Silencing Med12 gene reduces proliferation of human leiomyoma cells mediated via Wnt\/\u03b2-catenin signaling pathway. Endocrinology 158 592\u2013603. (https:\/\/doi.org\/10.1210\/en.2016-1097)"},{"key":"bib1","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"e1517","article-title":"Activation of \u03b2-catenin signaling and its crosstalk with estrogen and histone deacetylases in human uterine fibroids","volume":"105","author":"Ali","year":"2020","unstructured":"Ali MShahin SMSabri NAAl-Hendy A & Yang Q2020Activation of \u03b2-catenin signaling and its crosstalk with estrogen and histone deacetylases in human uterine fibroids. Journal of Clinical Endocrinology and Metabolism105e1517\u2013e1535. (https:\/\/doi.org\/10.1210\/clinem\/dgz227)"},{"key":"bib2","series-title":"Modern Pathology","first-page":"1144","article-title":"MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma","volume":"27","author":"Bertsch","year":"2014","unstructured":"Bertsch EQiang WZhang QEspona-Fiedler MDruschitz SLiu YMittal KKong BKurita T & Wei JJ2014MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma. Modern Pathology271144\u20131153. (https:\/\/doi.org\/10.1038\/modpathol.2013.243)"},{"key":"bib3","series-title":"Oncogene","first-page":"5356","article-title":"H19 lncRNA identified as a master regulator of genes that drive uterine leiomyomas","volume":"38","author":"Cao","year":"2019","unstructured":"Cao TJiang YWang ZZhang NAl-Hendy AMamillapalli RKallen ANKodaman PTaylor HSLi D, 2019H19 lncRNA identified as a master regulator of genes that drive uterine leiomyomas. Oncogene385356\u20135366. (https:\/\/doi.org\/10.1038\/s41388-019-0808-4)"},{"key":"bib4","series-title":"Journal of Pathology","first-page":"663","article-title":"Integrative analysis of the DNA methylome and transcriptome in uterine leiomyoma shows altered regulation of genes involved in metabolism, proliferation, extracellular matrix, and vesicles","volume":"257","author":"Carbajo-Garc\u00eda","year":"2022","unstructured":"Carbajo-Garc\u00eda MCCorach\u00e1n AJu\u00e1rez-Barber EMonle\u00f3n JPay\u00e1 VTrelis AQui\u00f1onero APellicer A & Ferrero H2022Integrative analysis of the DNA methylome and transcriptome in uterine leiomyoma shows altered regulation of genes involved in metabolism, proliferation, extracellular matrix, and vesicles. Journal of Pathology257663\u2013673. (https:\/\/doi.org\/10.1002\/path.5920)"},{"key":"bib5","series-title":"Fertility and Sterility","first-page":"919","article-title":"Next-generation sequencing reveals differentially expressed small noncoding RNAs in uterine leiomyoma","volume":"109","author":"Chuang","year":"2018","unstructured":"Chuang TDXie YYan W & Khorram O2018Next-generation sequencing reveals differentially expressed small noncoding RNAs in uterine leiomyoma. Fertility and Sterility109919\u2013929. (https:\/\/doi.org\/10.1016\/j.fertnstert.2018.01.034)"},{"key":"bib6","series-title":"Endocrinology","first-page":"bqab186","article-title":"Long noncoding RNA MIAT modulates the extracellular matrix deposition in leiomyomas by sponging MiR-29 family","volume":"162","author":"Chuang","year":"2021","unstructured":"Chuang TDQuintanilla DBoos D & Khorram O2021Long noncoding RNA MIAT modulates the extracellular matrix deposition in leiomyomas by sponging MiR-29 family. Endocrinology162bqab186. (https:\/\/doi.org\/10.1210\/endocr\/bqab186)"},{"key":"bib7","series-title":"Reproductive Sciences","first-page":"2960","article-title":"Differential expression of super-enhancer-associated long non-coding RNAs in uterine leiomyomas","volume":"29","author":"Chuang","year":"2022","unstructured":"Chuang TDQuintanilla DBoos D & Khorram O2022Differential expression of super-enhancer-associated long non-coding RNAs in uterine leiomyomas. Reproductive Sciences292960\u20132976. (https:\/\/doi.org\/10.1007\/s43032-022-00981-4)"},{"key":"bib8","series-title":"International Journal of Molecular Sciences","first-page":"3742","article-title":"Differential expression of MED12-associated coding RNA transcripts in uterine leiomyomas","volume":"24","author":"Chuang","year":"2023","unstructured":"Chuang TDGao JQuintanilla DMcswiggin HBoos DYan W & Khorram O2023Differential expression of MED12-associated coding RNA transcripts in uterine leiomyomas. International Journal of Molecular Sciences243742. (https:\/\/doi.org\/10.3390\/ijms24043742)"},{"key":"bib9","series-title":"Fertility and Sterility","first-page":"512","article-title":"Vitamin D as an effective treatment in human uterine leiomyomas independent of mediator complex subunit 12 mutation","volume":"115","author":"Corach\u00e1n","year":"2021","unstructured":"Corach\u00e1n ATrejo MGCarbajo-Garc\u00eda MCMonle\u00f3n JEscrig JFaus APellicer ACervell\u00f3 I & Ferrero H2021Vitamin D as an effective treatment in human uterine leiomyomas independent of mediator complex subunit 12 mutation. Fertility and Sterility115512\u2013521. (https:\/\/doi.org\/10.1016\/j.fertnstert.2020.07.049)"},{"key":"bib10","series-title":"European Journal of Cancer","first-page":"1603","article-title":"MED12 and uterine smooth muscle oncogenesis: state of the art and perspectives","volume":"51","author":"Croce","year":"2015","unstructured":"Croce S & Chibon F2015MED12 and uterine smooth muscle oncogenesis: state of the art and perspectives. European Journal of Cancer511603\u20131610. (https:\/\/doi.org\/10.1016\/j.ejca.2015.04.023)"},{"key":"bib11","series-title":"Reproductive Sciences","first-page":"823","article-title":"Introduction of somatic mutation in MED12 induces Wnt4\/\u03b2-catenin and disrupts autophagy in human uterine myometrial cell","volume":"27","author":"El Andaloussi","year":"2020","unstructured":"El Andaloussi AAl-Hendy AIsmail NBoyer TG & Halder SK2020Introduction of somatic mutation in MED12 induces Wnt4\/\u03b2-catenin and disrupts autophagy in human uterine myometrial cell. Reproductive Sciences27823\u2013832. (https:\/\/doi.org\/10.1007\/s43032-019-00084-7)"},{"key":"bib12","series-title":"Gynecologic Oncology","first-page":"562","article-title":"HMGA2 and MED12 alterations frequently co-occur in uterine leiomyomas","volume":"150","author":"Galindo","year":"2018","unstructured":"Galindo LJHern\u00e1ndez-Beeftink TSalas AJung YReyes Rde Oca FMHern\u00e1ndez M & Almeida TA2018HMGA2 and MED12 alterations frequently co-occur in uterine leiomyomas. Gynecologic Oncology150562\u2013568. (https:\/\/doi.org\/10.1016\/j.ygyno.2018.07.007)"},{"key":"bib13","series-title":"Oncology Letters","first-page":"74","article-title":"The role of mediator subunit 12 in tumorigenesis and cancer therapeutics","volume":"23","author":"Gonzalez","year":"2022","unstructured":"Gonzalez CGAkula S & Burleson M2022The role of mediator subunit 12 in tumorigenesis and cancer therapeutics. Oncology Letters2374. (https:\/\/doi.org\/10.3892\/ol.2022.13194)"},{"key":"bib14","series-title":"Reproductive Sciences","first-page":"357","article-title":"Frequency of MED12 mutation in relation to tumor and Patient's clinical characteristics: a meta-analysis","volume":"29","author":"He","year":"2022","unstructured":"He CNelson WLi HXu YDDai XJWang YXDing YBLi YP & Li T2022Frequency of MED12 mutation in relation to tumor and Patient's clinical characteristics: a meta-analysis. Reproductive Sciences29357\u2013365. (https:\/\/doi.org\/10.1007\/s43032-021-00473-x)"},{"key":"bib15","series-title":"Scientific Reports","first-page":"1015","article-title":"Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas","volume":"7","author":"Heinonen","year":"2017","unstructured":"Heinonen HRPasanen AHeikinheimo OTanskanen TPalin KTolvanen JVahteristo PSj\u00f6berg JPitk\u00e4nen EB\u00fctzow R, 2017Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas. Scientific Reports71015. (https:\/\/doi.org\/10.1038\/s41598-017-01199-0)"},{"key":"bib16","series-title":"Reproductive Sciences","first-page":"743","article-title":"Tryptophan 2,3-Dioxygenase-2 in uterine leiomyoma: dysregulation by MED12 mutation status","volume":"29","author":"Hutchinson","year":"2022","unstructured":"Hutchinson APYin PNeale ICoon JStKujawa SALiu S & Bulun SE2022Tryptophan 2,3-Dioxygenase-2 in uterine leiomyoma: dysregulation by MED12 mutation status. Reproductive Sciences29743\u2013749. (https:\/\/doi.org\/10.1007\/s43032-022-00852-y)"},{"key":"bib17","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"1842","article-title":"RANKL\/RANK pathway and its inhibitor RANK-Fc in uterine leiomyoma growth","volume":"103","author":"Ikhena","year":"2018","unstructured":"Ikhena DELiu SKujawa SEsencan ECoon JSTRobins JBulun SE & Yin P2018RANKL\/RANK pathway and its inhibitor RANK-Fc in uterine leiomyoma growth. Journal of Clinical Endocrinology and Metabolism1031842\u20131849. (https:\/\/doi.org\/10.1210\/jc.2017-01585)"},{"key":"bib18","series-title":"Endocrinology","first-page":"2433","article-title":"Progesterone is essential for maintenance and growth of uterine leiomyoma","volume":"151","author":"Ishikawa","year":"2010","unstructured":"Ishikawa HIshi KSerna VAKakazu RBulun SE &Kurita T2010Progesterone is essential for maintenance and growth of uterine leiomyoma. Endocrinology1512433\u20132442. (https:\/\/doi.org\/10.1210\/en.2009-1225)"},{"key":"bib19","series-title":"Human Reproduction Update","first-page":"59","article-title":"Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics","volume":"24","author":"Islam","year":"2018","unstructured":"Islam MSCiavattini APetraglia FCastellucci M & Ciarmela P2018Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics. Human Reproduction Update2459\u201385. (https:\/\/doi.org\/10.1093\/humupd\/dmx032)"},{"key":"bib20","series-title":"Endocrinology","first-page":"1106","article-title":"Proteomic profiling of human uterine fibroids reveals upregulation of the extracellular matrix protein periostin","volume":"159","author":"Jamaluddin","year":"2018a","unstructured":"Jamaluddin MFBKo YAKumar MBrown YBajwa PNagendra PBSkerrett-Byrne DAHondermarck HBaker MADun MD, 2018aProteomic profiling of human uterine fibroids reveals upregulation of the extracellular matrix protein periostin. Endocrinology1591106\u20131118. (https:\/\/doi.org\/10.1210\/en.2017-03018)"},{"key":"bib21","series-title":"Endocrinology","first-page":"2656","article-title":"Proteomic characterization of the extracellular matrix of human uterine fibroids","volume":"159","author":"Jamaluddin","year":"2018b","unstructured":"Jamaluddin MFBNahar P & Tanwar PS2018bProteomic characterization of the extracellular matrix of human uterine fibroids. Endocrinology1592656\u20132669. (https:\/\/doi.org\/10.1210\/en.2018-00151)"},{"key":"bib22","series-title":"Reproductive Sciences","first-page":"476","article-title":"Proteomic analysis identifies tenascin-C expression is upregulated in uterine fibroids","volume":"26","author":"Jamaluddin","year":"2019","unstructured":"Jamaluddin MFBNagendra PBNahar POldmeadow C & Tanwar PS2019Proteomic analysis identifies tenascin-C expression is upregulated in uterine fibroids. Reproductive Sciences26476\u2013486. (https:\/\/doi.org\/10.1177\/1933719118773420)"},{"key":"bib23","series-title":"British Journal of Cancer","first-page":"1405","article-title":"MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas","volume":"114","author":"K\u00e4mpj\u00e4rvi","year":"2016","unstructured":"K\u00e4mpj\u00e4rvi KM\u00e4kinen NMehine MV\u00e4lipakka SUimari OPitk\u00e4nen EHeinonen HRHeikkinen TTolvanen JAhtikoski A, 2016MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas. British Journal of Cancer1141405\u20131411. (https:\/\/doi.org\/10.1038\/bjc.2016.130)"},{"key":"bib24","series-title":"Reproduction","first-page":"61","article-title":"Extracellular matrix (ECM) activates \u03b2-catenin signaling in uterine fibroids","volume":"155","author":"Ko","year":"2018","unstructured":"Ko YAJamaluddin MFBAdebayo MBajwa PScott RJDharmarajan AMNahar P & Tanwar PS2018Extracellular matrix (ECM) activates \u03b2-catenin signaling in uterine fibroids. Reproduction15561\u201371. (https:\/\/doi.org\/10.1530\/REP-17-0339)"},{"key":"bib25","series-title":"Human Molecular Genetics","first-page":"1063","article-title":"Molecular subclass of uterine fibroids predicts tumor shrinkage in response to ulipristal acetate","volume":"32","author":"Kolterud","year":"2023","unstructured":"Kolterud \u00c5V\u00e4lim\u00e4ki NKuisma HPatomo JIlves STM\u00e4kinen NKaukomaa JPalin KKaasinen EKarhu A, 2023Molecular subclass of uterine fibroids predicts tumor shrinkage in response to ulipristal acetate. Human Molecular Genetics321063\u20131071. (https:\/\/doi.org\/10.1093\/hmg\/ddac217)"},{"key":"bib26","series-title":"Cell and Bioscience","first-page":"111","article-title":"Myometrial oxidative stress drives MED12 mutations in leiomyoma","volume":"12","author":"Li","year":"2022","unstructured":"Li YXu XAsif HFeng YKohrn BFKennedy SRKim JJ & Wei JJ2022Myometrial oxidative stress drives MED12 mutations in leiomyoma. Cell and Bioscience12111. (https:\/\/doi.org\/10.1186\/s13578-022-00852-0)"},{"key":"bib27","series-title":"Oncogene","first-page":"2722","article-title":"Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma","volume":"38","author":"Liu","year":"2019","unstructured":"Liu SYin PKujawa SACoon JSTOkeigwe I & Bulun SE2019Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma. Oncogene382722\u20132735. (https:\/\/doi.org\/10.1038\/s41388-018-0612-6)"},{"key":"bib28","series-title":"Scientific Reports","first-page":"8912","article-title":"Different DNA methylome, transcriptome and histological features in uterine fibroids with and without MED12 mutations","volume":"12","author":"Maekawa","year":"2022","unstructured":"Maekawa RSato STamehisa TSakai TKajimura TSueoka K & Sugino N2022Different DNA methylome, transcriptome and histological features in uterine fibroids with and without MED12 mutations. Scientific Reports128912. (https:\/\/doi.org\/10.1038\/s41598-022-12899-7)"},{"key":"bib29","series-title":"European Journal of Human Genetics","first-page":"1300","article-title":"MED12 exon 2 mutations in histopathological uterine leiomyoma variants","volume":"21","author":"M\u00e4kinen","year":"2013","unstructured":"M\u00e4kinen NVahteristo PK\u00e4mpj\u00e4rvi KArola JB\u00fctzow R & Aaltonen LA2013MED12 exon 2 mutations in histopathological uterine leiomyoma variants. European Journal of Human Genetics211300\u20131303. (https:\/\/doi.org\/10.1038\/ejhg.2013.33)"},{"key":"bib30","series-title":"Molecular Cancer","first-page":"101","article-title":"Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors","volume":"16","author":"M\u00e4kinen","year":"2017","unstructured":"M\u00e4kinen NK\u00e4mpj\u00e4rvi KFrizzell NB\u00fctzow R & Vahteristo P2017Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors. Molecular Cancer16101. (https:\/\/doi.org\/10.1186\/s12943-017-0672-1)"},{"key":"bib31","series-title":"Nature Reviews. Genetics","first-page":"761","article-title":"The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation","volume":"11","author":"Malik","year":"2010","unstructured":"Malik S & Roeder RG2010The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nature Reviews. Genetics11761\u2013772. (https:\/\/doi.org\/10.1038\/nrg2901)"},{"key":"bib32","series-title":"International Journal of Cancer","first-page":"1528","article-title":"12 mutations in uterine fibroids\u2013their relationship to cytogenetic subgroups","volume":"131","author":"Markowski","year":"2012","unstructured":"Markowski DNBartnitzke SL\u00f6ning TDrieschner NHelmke BM & Bullerdiek J201212 mutations in uterine fibroids\u2013their relationship to cytogenetic subgroups. International Journal of Cancer1311528\u20131536. (https:\/\/doi.org\/10.1002\/ijc.27424)"},{"key":"bib33","series-title":"Cancer Research","first-page":"4719","article-title":"Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia","volume":"68","author":"Mayer","year":"2008","unstructured":"Mayer AH\u00f6ckel MWree ALeo CHorn LC & Vaupel P2008Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia. Cancer Research684719\u20134726. (https:\/\/doi.org\/10.1158\/0008-5472.CAN-07-6339)"},{"key":"bib34","series-title":"Proceedings of the National Academy of Sciences of the United States of America","first-page":"1315","article-title":"Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers","volume":"113","author":"Mehine","year":"2016","unstructured":"Mehine MKaasinen EHeinonen HRM\u00e4kinen NK\u00e4mpj\u00e4rvi KSarvilinna NAavikko MV\u00e4h\u00e4rautio APasanen AB\u00fctzow R, 2016Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers. Proceedings of the National Academy of Sciences of the United States of America1131315\u20131320. (https:\/\/doi.org\/10.1073\/pnas.1518752113)"},{"key":"bib35","series-title":"Molecular Human Reproduction","first-page":"556","article-title":"MicroRNAs involved in the HMGA2 deregulation and its co-occurrence with MED12 mutation in uterine leiomyoma","volume":"24","author":"Mello","year":"2018","unstructured":"Mello JBHBarros-Filho MCAbreu FBCirilo PDRDomingues MACPontes A & Rogatto SR2018MicroRNAs involved in the HMGA2 deregulation and its co-occurrence with MED12 mutation in uterine leiomyoma. Molecular Human Reproduction24556\u2013563. (https:\/\/doi.org\/10.1093\/molehr\/gay037)"},{"key":"bib36","series-title":"Journal of Clinical Investigation","first-page":"3280","article-title":"Med12 gain-of-function mutation causes leiomyomas and genomic instability","volume":"125","author":"Mittal","year":"2015","unstructured":"Mittal PShin YHYatsenko SACastro CASurti U & Rajkovic A2015Med12 gain-of-function mutation causes leiomyomas and genomic instability. Journal of Clinical Investigation1253280\u20133284. (https:\/\/doi.org\/10.1172\/JCI81534)"},{"key":"bib37","series-title":"Scientific Reports","first-page":"6169","article-title":"Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids","volume":"12","author":"Muralimanoharan","year":"2022","unstructured":"Muralimanoharan SShamby RStansbury NSchenken RDe La Pena Avalos BJavanmardi SDray ESung P & Boyer TG2022Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids. Scientific Reports126169. (https:\/\/doi.org\/10.1038\/s41598-022-10188-x)"},{"key":"bib38","series-title":"American Journal of Obstetrics and Gynecology","first-page":"207.e1","article-title":"MED12 mutations in uterine leiomyomas: prediction of volume reduction by gonadotropin-releasing hormone agonists","volume":"228","author":"Nagai","year":"2022","unstructured":"Nagai KAsano RSekiguchi FAsai-Sato MMiyagi Y & Miyagi E2022MED12 mutations in uterine leiomyomas: prediction of volume reduction by gonadotropin-releasing hormone agonists. American Journal of Obstetrics and Gynecology228207.e1\u2013207.e9. (https:\/\/doi.org\/10.1016\/j.ajog.2022.09.024)"},{"key":"bib39","series-title":"Proceedings of the National Academy of Sciences of the United States of America","first-page":"17053","article-title":"Paracrine activation of WNT\/\u03b2-catenin pathway in uterine leiomyoma stem cells promotes tumor growth","volume":"110","author":"Ono","year":"2013","unstructured":"Ono MYin PNavarro AMoravek MBCoon JSTDruschitz SASerna VAQiang WBrooks DCMalpani SS, 2013Paracrine activation of WNT\/\u03b2-catenin pathway in uterine leiomyoma stem cells promotes tumor growth. Proceedings of the National Academy of Sciences of the United States of America11017053\u201317058. (https:\/\/doi.org\/10.1073\/pnas.1313650110)"},{"key":"bib40","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"4283","article-title":"Mediator kinase disruption in MED12-mutant uterine fibroids from Hispanic women of South Texas","volume":"103","author":"Park","year":"2018a","unstructured":"Park MJShen HKim NHGao FFailor CKnudtson JFMclaughlin JHalder SKHeikkinen TAVahteristo P, 2018aMediator kinase disruption in MED12-mutant uterine fibroids from Hispanic women of South Texas. Journal of Clinical Endocrinology and Metabolism1034283\u20134292. (https:\/\/doi.org\/10.1210\/jc.2018-00863)"},{"key":"bib41","series-title":"Journal of Biological Chemistry","first-page":"4870","article-title":"Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8\/19","volume":"293","author":"Park","year":"2018b","unstructured":"Park MJShen HSpaeth JMTolvanen JHFailor CKnudtson JFMclaughlin JHalder SKYang QBulun SE, 2018bOncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8\/19. Journal of Biological Chemistry2934870\u20134882. (https:\/\/doi.org\/10.1074\/jbc.RA118.001725)"},{"key":"bib42","series-title":"Endocrine-Related Cancer","first-page":"747","article-title":"Cellular kinetics of MED12-mutant uterine leiomyoma growth and regression in vivo","volume":"25","author":"Serna","year":"2018","unstructured":"Serna VAWu XQiang WThomas JBlumenfeld ML & Kurita T2018Cellular kinetics of MED12-mutant uterine leiomyoma growth and regression in vivo. Endocrine-Related Cancer25747\u2013759. (https:\/\/doi.org\/10.1530\/ERC-18-0184)"},{"key":"bib43","series-title":"Physiology (Bethesda)","first-page":"16","article-title":"Uterine fibroids: hiding in plain sight","volume":"37","author":"Stewart","year":"2022","unstructured":"Stewart EA & Nowak RA2022Uterine fibroids: hiding in plain sight. Physiology (Bethesda)3716\u201327. (https:\/\/doi.org\/10.1152\/physiol.00013.2021)"},{"key":"bib44","series-title":"F&S Science","first-page":"288","article-title":"A mediator complex subunit 12 gain-of-function mutation induces partial leiomyoma cell properties in human uterine smooth muscle cells","volume":"3","author":"Takao","year":"2022","unstructured":"Takao TOno MYoshimasa YMasuda H & Maruyama T2022A mediator complex subunit 12 gain-of-function mutation induces partial leiomyoma cell properties in human uterine smooth muscle cells. F&S Science3288\u2013298. (https:\/\/doi.org\/10.1016\/j.xfss.2022.04.002)"},{"key":"bib45","series-title":"Journal of Medical Economics","first-page":"1255","article-title":"Burden of menstrual symptoms in Japanese women: results from a survey-based study","volume":"16","author":"Tanaka","year":"2013","unstructured":"Tanaka EMomoeda MOsuga YRossi BNomoto KHayakawa MKokubo K & Wang EC2013Burden of menstrual symptoms in Japanese women: results from a survey-based study. Journal of Medical Economics161255\u20131266. (https:\/\/doi.org\/10.3111\/13696998.2013.830974)"},{"key":"bib46","series-title":"Cell Reports","first-page":"654","article-title":"Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity","volume":"7","author":"Turunen","year":"2014","unstructured":"Turunen MSpaeth JMKeskitalo SPark MJKivioja TClark ADM\u00e4kinen NGao FPalin KNurkkala H, 2014Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity. Cell Reports7654\u2013660. (https:\/\/doi.org\/10.1016\/j.celrep.2014.03.047)"},{"key":"bib47","series-title":"Endocrine Reviews","first-page":"678","article-title":"Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment","volume":"43","author":"Yang","year":"2022","unstructured":"Yang QCiebiera MBariani MVAli MElkafas HBoyer TG & Al-Hendy A2022Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment. Endocrine Reviews43678\u2013719. (https:\/\/doi.org\/10.1210\/endrev\/bnab039)"}],"container-title":["Journal of Molecular Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/jme.bioscientifica.com\/view\/journals\/jme\/71\/4\/JME-23-0039.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jme.bioscientifica.com\/downloadpdf\/journals\/jme\/71\/4\/JME-23-0039.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jme.bioscientifica.com\/downloadpdf\/journals\/jme\/71\/4\/JME-23-0039.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:54:20Z","timestamp":1784555660000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/jme\/article\/14590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,5]]},"references-count":48,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/jme-23-0039","relation":{},"ISSN":["0952-5041","1479-6813"],"issn-type":[{"value":"0952-5041","type":"print"},{"value":"1479-6813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,5]]}}}